MAOA - Amine oxidase [flavin-containing] A - human protein (Function)
 
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Protein
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References

 
MAOA »  Amine oxidase [flavin-containing] A   [ EC 1.4.3.4 ]
 
Protein also known as:  Monoamine oxidase type A (MAO-A).
Gene name:  MAOA
Entry whose protein(s) existence is based on evidence at protein level
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1 228 2
GENE REF ISO

Function

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Overview 
Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.  
  • CuratedUniProtKB
GO biological process 
Cellular biogenic amine metabolic processdefinition[GO:0006576]  
1
  • TASPINC
Dopamine catabolic processdefinition[GO:0042420] silver  
  • IEAOrtholog Compara
Neurotransmitter catabolic processdefinition[GO:0042135]  
  • IEAUniProtKB KW
Oxidation-reduction processdefinition[GO:0055114]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.4.3.4: RCH(2)NHR' + H(2)O + O(2) RCHO + R'NH(2) + H(2)O(2).  
  • CuratedUniProtKB
It requires the following cofactor
FAD.  
2
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Arginine and proline metabolism  hsa00330+4128  
Dopaminergic synapse  hsa04728+4128  
Drug metabolism - cytochrome P450  hsa00982+4128  
Glycine, serine and threonine metabolism  hsa00260+4128  
Histidine metabolism  hsa00340+4128  
Metabolic pathways  hsa01100+4128  
Phenylalanine metabolism  hsa00360+4128  
Tryptophan metabolism  hsa00380+4128  
Tyrosine metabolism  hsa00350+4128  
According to Reactome, this protein belongs to the following pathways:
Enzymatic degradation of dopamine by COMT  REACT_15548  
Enzymatic degradation of Dopamine by monoamine oxidase  REACT_15511  
Metabolism of serotonin  REACT_15532  
Monoamines are oxidized to aldehydes by MAOA and MAOB, producing NH3 and H2O2  REACT_416  
Norepinephrine Neurotransmitter Release Cycle  REACT_15418  
 
More information is available from:
 

Keywords

Biological process 
Catecholamine metabolism  definition   [KW-0128]
Neurotransmitter degradation  definition   [KW-0531]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P21397
Other
GeneWiki: Monoamine_oxidase_A
GenomeRNAi: 4128
PRO: PR:P21397
Chemistry
GuidetoPHARMACOLOGY: 2489