ACO1 - Cytoplasmic aconitate hydratase - human protein (Function)
 
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ACO1 »  Cytoplasmic aconitate hydratase   [ EC 4.2.1.3 ]  (Aconitase)
 
Protein also known as:  Iron-responsive element-binding protein 1 (IRE-BP 1).
Gene name:  ACO1
Entry whose protein(s) existence is based on evidence at protein level
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1 69 1
GENE REF ISO

Function

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Overview 
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.  
3
  • UniProtKB
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.  
1
  • UniProtKB
GO molecular function 
4 iron, 4 sulfur cluster bindingdefinition[GO:0051539]  
1
  • UniProtKB
Aconitate hydratase activitydefinition[GO:0003994]  
2
  • UniProtKB
Iron-responsive element bindingdefinition[GO:0030350]  
1
  • UniProtKB
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
  • UniProtKB
RNA bindingdefinition[GO:0003723]  
2
  • UniProtKB
GO biological process 
Cellular iron ion homeostasisdefinition[GO:0006879] silver  
1
  • Ortholog Compara
Citrate metabolic processdefinition[GO:0006101]  
2
  • HGNC
  • UniProtKB
Intestinal absorptiondefinition[GO:0050892] silver  
1
  • Ortholog Compara
Post-embryonic developmentdefinition[GO:0009791] silver  
1
  • Ortholog Compara
Regulation of translationdefinition[GO:0006417] silver  
1
  • Ortholog Compara
Response to iron(II) iondefinition[GO:0010040]  
1
  • UniProtKB
Tricarboxylic acid cycledefinition[GO:0006099]  
1
  • UniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.2.1.3: Citrate isocitrate.  
1
  • UniProtKB
It requires the following cofactor
 [4Fe-4S] cluster : Binds 1 [4Fe-4S] cluster per subunit.  
2
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Citrate cycle (TCA cycle)  hsa00020+48  
Glyoxylate and dicarboxylate metabolism  hsa00630+48  
Metabolic pathways  hsa01100+48  
 
More information is available from:
 

Keywords

Biological process 
Tricarboxylic acid cycle  definition   [KW-0816]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GenomeRNAi: 48
PRO: PR:P21399
Protein family/group databases
MoonProt: P21399