ACO1 - Cytoplasmic aconitate hydratase - human protein (Function)
 
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ACO1 »  Cytoplasmic aconitate hydratase   [ EC 4.2.1.3 ]  (Aconitase)
 
Protein also known as:  Iron-responsive element-binding protein 1 (IRE-BP 1).
Gene name:  ACO1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 58 1
GENE REF ISO

Function

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Overview 
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.  
2
  • CuratedUniProtKB
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate (By similarity).  
2
  • CuratedUniProtKB
GO molecular function 
4 iron, 4 sulfur cluster bindingdefinition[GO:0051539]  
1
  • IDAUniProtKB
Aconitate hydratase activitydefinition[GO:0003994]  
2
  • IDAUniProtKB
Iron-responsive element bindingdefinition[GO:0030350]  
1
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
RNA bindingdefinition[GO:0003723]  
2
  • IDAUniProtKB
GO biological process 
Cellular iron ion homeostasisdefinition[GO:0006879] silver  
  • IEAOrtholog Compara
Citrate metabolic processdefinition[GO:0006101]  
2
  • IDAHGNC
  • IDAUniProtKB
Intestinal absorptiondefinition[GO:0050892] silver  
  • IEAOrtholog Compara
Post-embryonic developmentdefinition[GO:0009791] silver  
  • IEAOrtholog Compara
Regulation of translationdefinition[GO:0006417] silver  
  • IEAOrtholog Compara
Response to iron(II) iondefinition[GO:0010040]  
1
  • IDAUniProtKB
Tricarboxylic acid cycledefinition[GO:0006099]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.2.1.3: Citrate isocitrate.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 4Fe-4S cluster per subunit.  
1
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Citrate cycle (TCA cycle)  hsa00020+48  
Glyoxylate and dicarboxylate metabolism  hsa00630+48  
Metabolic pathways  hsa01100+48  
 
More information is available from:
 

Keywords

Biological process 
Tricarboxylic acid cycle  definition   [KW-0816]
Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 48
PRO: PR:P21399