ABCB4 - Multidrug resistance protein 3 - human protein (Function)
 
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Protein
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ABCB4 »  Multidrug resistance protein 3   [ EC 3.6.3.44 ]
 
Protein also known as:  ATP-binding cassette sub-family B member 4.
Gene name:  ABCB4
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 81 3
GENE REF ISO

Function

 show evidences
Overview 
Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the atp-binding cassette (abc) superfamily  3.A.1.201.3  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
ATPase activity, coupled to transmembrane movement of substancesdefinition[GO:0042626] silver  
  • IBARefGenome
Xenobiotic-transporting ATPase activitydefinition[GO:0008559]  
  • IEAEC 2 GO
GO biological process 
ATP catabolic processdefinition[GO:0006200]  
  • IEAInterPro 2 GO
Drug transmembrane transportdefinition[GO:0006855]  
  • IEAEC 2 GO
Lipid metabolic processdefinition[GO:0006629]  
1
  • TASPINC
Response to drugdefinition[GO:0042493]  
1
  • TASPINC
Transmembrane transportdefinition[GO:0055085] silver  
  • IBARefGenome
Transportdefinition[GO:0006810]  
1
  • TASPINC
Xenobiotic transportdefinition[GO:0042908]  
  • IEAEC 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.3.44: ATP + H(2)O + xenobiotic(In) ADP + phosphate + xenobiotic(Out).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
ABC transporters  hsa02010+5244  
Bile secretion  hsa04976+5244  
According to Reactome, this protein belongs to the following pathway:
PPARA activates gene expression  REACT_116145  
 

Keywords

Biological process 
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ABCB4
GenomeRNAi: 5244
PRO: PR:P21439