S1PR1 - Sphingosine 1-phosphate receptor 1 - human protein (Function)
 
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S1PR1 »  Sphingosine 1-phosphate receptor 1  (S1P1)
 
Protein also known as:  Endothelial differentiation G-protein coupled receptor 1; CD antigen CD363.
Gene name:  S1PR1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.  
8
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.2.1  
GO molecular function 
G-protein coupled receptor activitydefinition[GO:0004930]  
1
  • TASPINC
G-protein coupled receptor bindingdefinition[GO:0001664]  
1
  • IPIUniProtKB
Sphingolipid bindingdefinition[GO:0046625] silver  
  • IEAOrtholog Compara
Sphingosine-1-phosphate receptor activitydefinition[GO:0038036]  
1
  • IDAUniProtKB
GO biological process 
Actin cytoskeleton reorganizationdefinition[GO:0031532]  
  • ISSOrtholog Curator
Adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwaydefinition[GO:0007193] silver  
  • IEAOrtholog Compara
Angiogenesisdefinition[GO:0001525] silver  
  • IEAOrtholog Compara
Blood vessel maturationdefinition[GO:0001955]  
  • ISSOrtholog Curator
Brain developmentdefinition[GO:0007420] silver  
  • IEAOrtholog Compara
Cardiac muscle tissue growth involved in heart morphogenesisdefinition[GO:0003245]  
  • ISSOrtholog Curator
Cell adhesiondefinition[GO:0007155]  
2
  • TASPINC
Cell migrationdefinition[GO:0016477]  
  • ISSOrtholog Curator
Chemotaxisdefinition[GO:0006935]  
  • ISSOrtholog Curator
Endothelial cell differentiationdefinition[GO:0045446] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • TASPINC
Heart trabecula morphogenesisdefinition[GO:0061384]  
  • ISSOrtholog Curator
Lamellipodium assemblydefinition[GO:0030032]  
  • ISSOrtholog Curator
Negative regulation of stress fiber assemblydefinition[GO:0051497] silver  
  • IEAOrtholog Compara
Neuron differentiationdefinition[GO:0030182] silver  
  • IEAOrtholog Compara
Positive regulation of cell migrationdefinition[GO:0030335] silver  
  • IEAOrtholog Compara
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwaydefinition[GO:0051482] silver  
  • IEAOrtholog Compara
Positive regulation of positive chemotaxisdefinition[GO:0050927] silver  
  • IEAOrtholog Compara
Positive regulation of Ras GTPase activitydefinition[GO:0032320] silver  
  • IEAOrtholog Compara
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Regulation of bone mineralizationdefinition[GO:0030500]  
  • ISSOrtholog Curator
Regulation of bone resorptiondefinition[GO:0045124]  
  • ISSOrtholog Curator
Regulation of cell adhesiondefinition[GO:0030155] silver  
  • IEAOrtholog Compara
Sphingosine-1-phosphate signaling pathwaydefinition[GO:0003376]  
1
  • IDAUniProtKB
T cell migrationdefinition[GO:0072678]  
  • ISSOrtholog Curator
Transmission of nerve impulsedefinition[GO:0019226] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+1901  
According to Reactome, this protein belongs to the following pathways:
G alpha (i) signalling events  REACT_19231  
Lysosphingolipid and LPA receptors  REACT_18365  
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Chemotaxis  definition   [KW-0145]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: S1PR1
GenomeRNAi: 1901
PRO: PR:P21453
Chemistry
GuidetoPHARMACOLOGY: 275