FPR1 - fMet-Leu-Phe receptor - human protein (Function)
 
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FPR1 »  fMet-Leu-Phe receptor  (fMLP receptor)
 
Protein also known as:  N-formylpeptide chemoattractant receptor.
Gene name:  FPR1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed2161213, PubMed2176894, PubMed10514456, PubMed15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed2161213, PubMed1712023, PubMed15153520). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed1712023, PubMed10514456).  
9
  • UniProtKB
GO molecular function 
N-formyl peptide receptor activitydefinition[GO:0004982]  
2
  • MGI
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
RAGE receptor bindingdefinition[GO:0050786] silver  
1
  • Ortholog Compara
Receptor activitydefinition[GO:0004872]  
1
  • PINC
GO biological process 
Activation of MAPK activitydefinition[GO:0000187]  
1
  • PINC
Adenylate cyclase-modulating G-protein coupled receptor signaling pathwaydefinition[GO:0007188]  
1
  • PINC
Cellular component movementdefinition[GO:0006928]  
1
  • PINC
Chemotaxisdefinition[GO:0006935]  
1
  • UniProtKB KW
G-protein coupled receptor signaling pathwaydefinition[GO:0007186]  
1
  • PINC
Nitric oxide mediated signal transductiondefinition[GO:0007263]  
1
  • PINC
Phospholipase C-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007200]  
1
  • MGI
Signal transductiondefinition[GO:0007165]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Neuroactive ligand-receptor interaction  hsa04080+2357  
Staphylococcus aureus infection  hsa05150+2357  
According to Reactome, this protein belongs to the following pathways:
Formyl peptide receptors bind formyl peptides and many other ligands  REACT_21264  
G alpha (i) signalling events  REACT_19231  
 

Keywords

Biological process 
Chemotaxis  definition   [KW-0145]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Formyl_peptide_receptor_1
GenomeRNAi: 2357
PRO: PR:P21462
Chemistry
GuidetoPHARMACOLOGY: 222