AGXT - Serine--pyruvate aminotransferase - human protein (Function)
 
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AGXT »  Serine--pyruvate aminotransferase   [ EC 2.6.1.51 ]  (SPT)
 
Protein also known as:  Alanine--glyoxylate aminotransferase [EC 2.6.1.44] (AGT).
Gene name:  AGXT
Entry whose protein(s) existence is based on evidence at protein level
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1 81 1
GENE REF ISO

Function

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GO molecular function 
Alanine-glyoxylate transaminase activitydefinition[GO:0008453]  
4
  • IDAUniProtKB
  • TASHGNC
Amino acid bindingdefinition[GO:0016597]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • IPIHGNC
Protein homodimerization activitydefinition[GO:0042803]  
2
  • IDAUniProtKB
  • IDAHGNC
Pyridoxal phosphate bindingdefinition[GO:0030170]  
3
  • IDAUniProtKB
  • IMPHGNC
Receptor bindingdefinition[GO:0005102]  
1
  • IPIUniProtKB
Serine-pyruvate transaminase activitydefinition[GO:0004760]  
  • IEAEC 2 GO
Transaminase activitydefinition[GO:0008483]  
2
  • IDAUniProtKB
GO biological process 
Glycine biosynthetic process, by transamination of glyoxylatedefinition[GO:0019265]  
1
  • IDAUniProtKB
Glyoxylate catabolic processdefinition[GO:0009436]  
1
  • IDAUniProtKB
Glyoxylate metabolic processdefinition[GO:0046487]  
1
  • IMPHGNC
L-alanine catabolic processdefinition[GO:0042853]  
3
  • IDAUniProtKB
L-cysteine catabolic processdefinition[GO:0019448]  
1
  • IDAUniProtKB
Oxalic acid secretiondefinition[GO:0046724] silver  
  • IEAOrtholog Compara
Protein targeting to peroxisomedefinition[GO:0006625]  
1
  • IMPHGNC
Pyruvate biosynthetic processdefinition[GO:0042866] silver  
  • IEAOrtholog Compara
Response to cAMPdefinition[GO:0051591] silver  
  • IEAOrtholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.6.1.51: L-serine + pyruvate 3-hydroxypyruvate + L-alanine.  
  • CuratedUniProtKB
EC 2.6.1.44: L-alanine + glyoxylate pyruvate + glycine.  
  • CuratedUniProtKB
It requires the following cofactor
Pyridoxal phosphate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alanine, aspartate and glutamate metabolism  hsa00250+189  
Glycine, serine and threonine metabolism  hsa00260+189  
Metabolic pathways  hsa01100+189  
Peroxisome  hsa04146+189  
According to Reactome, this protein belongs to the following pathway:
Glyoxylate metabolism  REACT_16925  
 
More information is available from:
 

Keywords

Molecular function 
Aminotransferase  definition   [KW-0032]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: AGXT
GenomeRNAi: 189
PRO: PR:P21549