AGXT - Serine--pyruvate aminotransferase - human protein (Function)
 
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AGXT »  Serine--pyruvate aminotransferase   [ EC 2.6.1.51 ]  (SPT)
 
Protein also known as:  Alanine--glyoxylate aminotransferase [EC 2.6.1.44] (AGT).
Gene name:  AGXT
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 82 1
GENE REF ISO

Function

 show evidences
GO molecular function 
Alanine-glyoxylate transaminase activitydefinition[GO:0008453]  
4
  • UniProtKB
  • HGNC
Amino acid bindingdefinition[GO:0016597]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
1
  • HGNC
Protein homodimerization activitydefinition[GO:0042803]  
2
  • UniProtKB
  • HGNC
Pyridoxal phosphate bindingdefinition[GO:0030170]  
3
  • UniProtKB
  • HGNC
Receptor bindingdefinition[GO:0005102]  
1
  • UniProtKB
Serine-pyruvate transaminase activitydefinition[GO:0004760]  
1
  • EC 2 GO
Transaminase activitydefinition[GO:0008483]  
2
  • UniProtKB
GO biological process 
Glycine biosynthetic process, by transamination of glyoxylatedefinition[GO:0019265]  
1
  • UniProtKB
Glyoxylate catabolic processdefinition[GO:0009436]  
1
  • UniProtKB
Glyoxylate metabolic processdefinition[GO:0046487]  
1
  • HGNC
L-alanine catabolic processdefinition[GO:0042853]  
3
  • UniProtKB
L-cysteine catabolic processdefinition[GO:0019448]  
1
  • UniProtKB
Oxalic acid secretiondefinition[GO:0046724] silver  
1
  • Ortholog Compara
Pyruvate biosynthetic processdefinition[GO:0042866] silver  
1
  • Ortholog Compara
Response to cAMPdefinition[GO:0051591] silver  
1
  • Ortholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 2.6.1.51: L-serine + pyruvate 3-hydroxypyruvate + L-alanine.  
1
  • UniProtKB
EC 2.6.1.44: L-alanine + glyoxylate pyruvate + glycine.  
1
  • UniProtKB
It requires the following cofactor
 pyridoxal 5'-phosphate  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Alanine, aspartate and glutamate metabolism  hsa00250+189  
Glycine, serine and threonine metabolism  hsa00260+189  
Metabolic pathways  hsa01100+189  
Peroxisome  hsa04146+189  
According to Reactome, this protein belongs to the following pathway:
Glyoxylate metabolism  REACT_16925  
 
More information is available from:
 

Keywords

Molecular function 
Aminotransferase  definition   [KW-0032]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: AGXT
GenomeRNAi: 189
PRO: PR:P21549