CNR1 - Cannabinoid receptor 1 - human protein (Function)
 
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Protein
Gene
References

 
CNR1 »  Cannabinoid receptor 1  (CB1)
 
Protein also known as:  CANN6.
Gene name:  CNR1
Entry whose protein(s) existence is based on evidence at protein level
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1 40 3
GENE REF ISO

Function

 show evidences
Overview 
Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current.  
1
  • CuratedUniProtKB
Isoforms  Iso 2 and Iso 3   Have altered ligand binding.  
1
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the g-protein-coupled receptor (gpcr) family  9.A.14.2.2  
GO molecular function 
Cannabinoid receptor activitydefinition[GO:0004949]  
1
  • IDAUniProtKB
Drug bindingdefinition[GO:0008144] silver  
  • IEAOrtholog Compara
GO biological process 
Adenylate cyclase-modulating G-protein coupled receptor signaling pathwaydefinition[GO:0007188]  
1
  • IDAUniProtKB
Agingdefinition[GO:0007568] silver  
  • IEAOrtholog Compara
Cannabinoid signaling pathwaydefinition[GO:0038171] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerdefinition[GO:0007187]  
1
  • TASPINC
Maternal process involved in female pregnancydefinition[GO:0060135] silver  
  • IEAOrtholog Compara
Memorydefinition[GO:0007613] silver  
  • IEAOrtholog Compara
Negative regulation of action potentialdefinition[GO:0045759] silver  
  • IEAOrtholog Compara
Negative regulation of blood pressuredefinition[GO:0045776] silver  
  • IEAOrtholog Compara
Negative regulation of dopamine secretiondefinition[GO:0033602] silver  
  • IEAOrtholog Compara
Negative regulation of fatty acid beta-oxidationdefinition[GO:0031999] silver  
  • IEAOrtholog Compara
Negative regulation of mast cell activationdefinition[GO:0033004] silver  
  • IEAOrtholog Compara
Negative regulation of nitric-oxide synthase activitydefinition[GO:0051001] silver  
  • IEAOrtholog Compara
Positive regulation of acute inflammatory response to antigenic stimulusdefinition[GO:0002866] silver  
  • IEAOrtholog Compara
Positive regulation of apoptotic processdefinition[GO:0043065] silver  
  • IEAOrtholog Compara
Positive regulation of blood pressuredefinition[GO:0045777] silver  
  • IEAOrtholog Compara
Positive regulation of fever generationdefinition[GO:0031622] silver  
  • IEAOrtholog Compara
Positive regulation of neuron projection developmentdefinition[GO:0010976] silver  
  • IEAOrtholog Compara
Regulation of feeding behaviordefinition[GO:0060259] silver  
  • IEAOrtholog Compara
Regulation of insulin secretiondefinition[GO:0050796] silver  
  • IEAOrtholog Compara
Regulation of penile erectiondefinition[GO:0060405] silver  
  • IEAOrtholog Compara
Regulation of synaptic transmission, GABAergicdefinition[GO:0032228] silver  
  • IEAOrtholog Compara
Regulation of synaptic transmission, glutamatergicdefinition[GO:0051966] silver  
  • IEAOrtholog Compara
Response to cocainedefinition[GO:0042220] silver  
  • IEAOrtholog Compara
Response to ethanoldefinition[GO:0045471] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Response to morphinedefinition[GO:0043278] silver  
  • IEAOrtholog Compara
Response to nicotinedefinition[GO:0035094] silver  
  • IEAOrtholog Compara
Response to nutrientdefinition[GO:0007584] silver  
  • IEAOrtholog Compara
Sensory perception of paindefinition[GO:0019233] silver  
  • IEAOrtholog Compara
Spermatogenesisdefinition[GO:0007283] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+1268  
According to Reactome, this protein belongs to the following pathways:
Class A/1 (Rhodopsin-like receptors)  REACT_14828  
G alpha (i) signalling events  REACT_19231  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Cannabinoid_receptor_type_1
GenomeRNAi: 1268
PRO: PR:P21554
Chemistry
GuidetoPHARMACOLOGY: 56