EPHA1 - Ephrin type-A receptor 1 - human protein (Function)
 
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Protein
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References

 
EPHA1 »  Ephrin type-A receptor 1   [ EC 2.7.10.1 ]
 
Protein also known as:  Erythropoietin-producing hepatoma receptor.
Gene name:  EPHA1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 61 1
GENE REF ISO

Function

 show evidences
Overview 
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.  
3
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Protein kinase activitydefinition[GO:0004672]  
1
  • IDAUniProtKB
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIUniProtKB
Transmembrane-ephrin receptor activitydefinition[GO:0005005]  
1
  • IDAUniProtKB
GO biological process 
Activation of Rho GTPase activitydefinition[GO:0032862]  
1
  • IDAUniProtKB
Angiogenesisdefinition[GO:0001525]  
  • IEAUniProtKB KW
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • IDAUniProtKB
Negative regulation of cell migrationdefinition[GO:0030336]  
1
  • IDAUniProtKB
Negative regulation of protein kinase activitydefinition[GO:0006469]  
1
  • IDAUniProtKB
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
1
  • IDAUniProtKB
Positive regulation of angiogenesisdefinition[GO:0045766]  
1
  • IMPUniProtKB
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • IMPUniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • IMPUniProtKB
Positive regulation of cell-matrix adhesiondefinition[GO:0001954]  
1
  • IDAUniProtKB
Positive regulation of stress fiber assemblydefinition[GO:0051496]  
  • ISSOrtholog Curator
Protein autophosphorylationdefinition[GO:0046777]  
1
  • IDAUniProtKB
Regulation of Rac GTPase activitydefinition[GO:0032314]  
1
  • IDAUniProtKB
Substrate adhesion-dependent cell spreadingdefinition[GO:0034446]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Axon guidance  hsa04360+2041  
According to Reactome, this protein belongs to the following pathway:
Developmental Biology  REACT_111045  
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Cell adhesion  definition   [KW-0130]
Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: EPH_receptor_A1
GenomeRNAi: 2041
PRO: PR:P21709
Chemistry
GuidetoPHARMACOLOGY: 1821