EPHA1 - Ephrin type-A receptor 1 - human protein (Function)
 
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EPHA1 »  Ephrin type-A receptor 1   [ EC 2.7.10.1 ]
 
Protein also known as:  Erythropoietin-producing hepatoma receptor.
Gene name:  EPHA1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.  
4
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Protein kinase activitydefinition[GO:0004672]  
1
  • UniProtKB
Protein kinase bindingdefinition[GO:0019901]  
1
  • UniProtKB
Transmembrane-ephrin receptor activitydefinition[GO:0005005]  
1
  • UniProtKB
GO biological process 
Activation of Rho GTPase activitydefinition[GO:0032862]  
1
  • UniProtKB
Angiogenesisdefinition[GO:0001525]  
1
  • UniProtKB KW
Cell surface receptor signaling pathwaydefinition[GO:0007166]  
1
  • UniProtKB
Ephrin receptor signaling pathwaydefinition[GO:0048013] silver  
1
  • InterPro 2 GO
Negative regulation of cell migrationdefinition[GO:0030336]  
1
  • UniProtKB
Negative regulation of protein kinase activitydefinition[GO:0006469]  
1
  • UniProtKB
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
1
  • UniProtKB
Positive regulation of angiogenesisdefinition[GO:0045766]  
1
  • UniProtKB
Positive regulation of cell migrationdefinition[GO:0030335]  
1
  • UniProtKB
Positive regulation of cell proliferationdefinition[GO:0008284]  
1
  • UniProtKB
Positive regulation of cell-matrix adhesiondefinition[GO:0001954]  
1
  • UniProtKB
Positive regulation of stress fiber assemblydefinition[GO:0051496]  
1
  • Ortholog Curator
Protein autophosphorylationdefinition[GO:0046777]  
1
  • UniProtKB
Regulation of Rac GTPase activitydefinition[GO:0032314]  
1
  • UniProtKB
Substrate adhesion-dependent cell spreadingdefinition[GO:0034446]  
1
  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
2
  • PROSITE-ProRule
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Axon guidance  hsa04360+2041  
According to Reactome, this protein belongs to the following pathways:
EPH-ephrin mediated repulsion of cells  REACT_228189  
EPH-Ephrin signaling  REACT_228170  
EPHA-mediated growth cone collapse  REACT_228063  
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation  REACT_200759  
 

Keywords

Biological process 
Angiogenesis  definition   [KW-0037]
Cell adhesion  definition   [KW-0130]
Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: EPH_receptor_A1
GenomeRNAi: 2041
PRO: PR:P21709
Chemistry
GuidetoPHARMACOLOGY: 1821