DRD1 - D(1A) dopamine receptor - human protein (Function)
 
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DRD1 »  D(1A) dopamine receptor
 
Protein also known as:  Dopamine D1 receptor.
Gene name:  DRD1
Entry whose protein(s) existence is based on evidence at protein level
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1 133 1
GENE REF ISO

Function

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Overview 
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.  
  • CuratedUniProtKB
GO molecular function 
Dopamine bindingdefinition[GO:0035240]  
1
  • IMPBHF-UCL
Dopamine neurotransmitter receptor activitydefinition[GO:0004952]  
1
  • IDAMGI
Dopamine neurotransmitter receptor activity, coupled via Gsdefinition[GO:0001588]  
4
  • IMPBHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIBHF-UCL
GO biological process 
Activation of adenylate cyclase activitydefinition[GO:0007190]  
1
  • IDABHF-UCL
Adenylate cyclase-activating dopamine receptor signaling pathwaydefinition[GO:0007191]  
3
  • IDABHF-UCL
Adenylate cyclase-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007189]  
2
  • IDAUniProtKB
  • IDABHF-UCL
Adult walking behaviordefinition[GO:0007628]  
  • ISSOrtholog Curator
Astrocyte developmentdefinition[GO:0014002] silver  
  • IEAOrtholog Compara
Behavioral fear responsedefinition[GO:0001662] silver  
  • IEAOrtholog Compara
Behavioral response to cocainedefinition[GO:0048148] silver  
  • IEAOrtholog Compara
Cellular response to catecholamine stimulusdefinition[GO:0071870]  
1
  • IDABHF-UCL
Cerebral cortex GABAergic interneuron migrationdefinition[GO:0021853]  
  • ISSOrtholog Curator
Conditioned taste aversiondefinition[GO:0001661] silver  
  • IEAOrtholog Compara
Dentate gyrus developmentdefinition[GO:0021542] silver  
  • IEAOrtholog Compara
Dopamine metabolic processdefinition[GO:0042417]  
1
  • ICBHF-UCL
Dopamine transportdefinition[GO:0015872] silver  
  • IEAOrtholog Compara
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerdefinition[GO:0007187]  
1
  • IDABHF-UCL
Glucose importdefinition[GO:0046323] silver  
  • IEAOrtholog Compara
Grooming behaviordefinition[GO:0007625] silver  
  • IEAOrtholog Compara
Habituationdefinition[GO:0046959] silver  
  • IEAOrtholog Compara
Long term synaptic depressiondefinition[GO:0060292] silver  
  • IEAOrtholog Compara
Long-term synaptic potentiationdefinition[GO:0060291] silver  
  • IEAOrtholog Compara
Maternal behaviordefinition[GO:0042711] silver  
  • IEAOrtholog Compara
Mating behaviordefinition[GO:0007617]  
  • ISSOrtholog Curator
Memorydefinition[GO:0007613] silver  
  • IEAOrtholog Compara
Neuronal action potentialdefinition[GO:0019228] silver  
  • IEAOrtholog Compara
Operant conditioningdefinition[GO:0035106] silver  
  • IEAOrtholog Compara
Peristalsisdefinition[GO:0030432] silver  
  • IEAOrtholog Compara
Phospholipase C-activating dopamine receptor signaling pathwaydefinition[GO:0060158]  
2
  • IGIMGI
  • IDABHF-UCL
Positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwaydefinition[GO:0010579] silver  
  • IEAInterPro 2 GO
Positive regulation of cAMP biosynthetic processdefinition[GO:0030819]  
2
  • IDABHF-UCL
Positive regulation of cell migrationdefinition[GO:0030335]  
  • ISSOrtholog Curator
Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathwaydefinition[GO:0051482]  
1
  • IDABHF-UCL
Positive regulation of potassium ion transportdefinition[GO:0043268]  
  • ISSOrtholog Curator
Positive regulation of release of sequestered calcium ion into cytosoldefinition[GO:0051281]  
2
  • IDABHF-UCL
Positive regulation of synaptic transmission, glutamatergicdefinition[GO:0051968]  
  • ISSOrtholog Curator
Prepulse inhibitiondefinition[GO:0060134]  
  • ISSOrtholog Curator
Protein import into nucleusdefinition[GO:0006606] silver  
  • IEAOrtholog Compara
Regulation of dopamine metabolic processdefinition[GO:0042053] silver  
  • IEAOrtholog Compara
Regulation of dopamine uptake involved in synaptic transmissiondefinition[GO:0051584]  
1
  • ICBHF-UCL
Response to amphetaminedefinition[GO:0001975] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493]  
  • ISSOrtholog Curator
Sensitizationdefinition[GO:0046960] silver  
  • IEAOrtholog Compara
Striatum developmentdefinition[GO:0021756] silver  
  • IEAOrtholog Compara
Synapse assemblydefinition[GO:0007416]  
  • ISSOrtholog Curator
Synaptic transmission, dopaminergicdefinition[GO:0001963] silver  
  • IEAOrtholog Compara
Temperature homeostasisdefinition[GO:0001659] silver  
  • IEAOrtholog Compara
Transmission of nerve impulsedefinition[GO:0019226]  
  • ISSOrtholog Curator
Vasodilationdefinition[GO:0042311] silver  
  • IEAInterPro 2 GO
Visual learningdefinition[GO:0008542]  
  • ISSOrtholog Curator
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+1812  
Dopaminergic synapse  hsa04728+1812  
Gap junction  hsa04540+1812  
Neuroactive ligand-receptor interaction  hsa04080+1812  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Dopamine_receptor_D1
GenomeRNAi: 1812
PRO: PR:P21728
Chemistry
GuidetoPHARMACOLOGY: 214