C5AR1 - C5a anaphylatoxin chemotactic receptor 1 - human protein (Function)
 
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C5AR1 »  C5a anaphylatoxin chemotactic receptor 1
 
Protein also known as:  C5a anaphylatoxin chemotactic receptor (C5aR); CD antigen CD88.
Gene name:  C5AR1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 104 1
GENE REF ISO

Function

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Overview 
Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed1847994, PubMed8182049, PubMed7622471, PubMed9553099, PubMed10636859, PubMed15153520). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed8182049, PubMed7622471, PubMed9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed10636859, PubMed15153520).  
7
  • UniProtKB
GO molecular function 
C5a anaphylatoxin receptor activitydefinition[GO:0004944]  
1
  • UniProtKB
Complement component C5a bindingdefinition[GO:0001856] silver  
1
  • Ortholog Compara
Complement component C5a receptor activitydefinition[GO:0004878]  
1
  • UniProtKB
GO biological process 
Activation of MAPK activitydefinition[GO:0000187]  
1
  • PINC
Activation of phospholipase C activitydefinition[GO:0007202]  
1
  • PINC
Apoptotic processdefinition[GO:0006915] silver  
1
  • Ortholog Compara
Cell proliferation in hindbraindefinition[GO:0021534] silver  
1
  • Ortholog Compara
Cellular defense responsedefinition[GO:0006968]  
1
  • PINC
Chemotaxisdefinition[GO:0006935]  
1
  • PINC
Complement component C5a signaling pathwaydefinition[GO:0038178]  
1
  • GOC
Defense response to Gram-positive bacteriumdefinition[GO:0050830] silver  
1
  • Ortholog Compara
Immune responsedefinition[GO:0006955]  
1
  • PINC
Inflammatory responsedefinition[GO:0006954] silver  
1
  • Ortholog Compara
mRNA transcription from RNA polymerase II promoterdefinition[GO:0042789]  
1
  • UniProtKB
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
1
  • Ortholog Compara
Neutrophil chemotaxisdefinition[GO:0030593] silver  
1
  • Ortholog Compara
Organ regenerationdefinition[GO:0031100] silver  
1
  • Ortholog Compara
Positive regulation of cytosolic calcium ion concentrationdefinition[GO:0007204] silver  
1
  • Ortholog Compara
Positive regulation of epithelial cell proliferationdefinition[GO:0050679]  
1
  • UniProtKB
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • UniProtKB
Response to lipopolysaccharidedefinition[GO:0032496] silver  
1
  • Ortholog Compara
Response to peptidoglycandefinition[GO:0032494] silver  
1
  • Ortholog Compara
Sensory perception of chemical stimulusdefinition[GO:0007606]  
1
  • PINC
Signal transductiondefinition[GO:0007165]  
2
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Complement and coagulation cascades  hsa04610+728  
Neuroactive ligand-receptor interaction  hsa04080+728  
Staphylococcus aureus infection  hsa05150+728  
According to Reactome, this protein belongs to the following pathways:
G alpha (i) signalling events  REACT_19231  
Peptide ligand-binding receptors  REACT_14819  
 

Keywords

Biological process 
Chemotaxis  definition   [KW-0145]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: C5a_receptor
GenomeRNAi: 728
PRO: PR:P21730
Chemistry
GuidetoPHARMACOLOGY: 32