ZP3 - Zona pellucida sperm-binding protein 3 - human protein (Function)
 
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ZP3 »  Zona pellucida sperm-binding protein 3
 
Protein also known as:  Zona pellucida glycoprotein 3 (Zp-3). Cleaved into:  Processed zona pellucida sperm-binding protein 3.
Gene name:  ZP3
Family name: ZP domain » ZPC
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 27 3
GENE REF ISO

Function

 show evidences
Overview 
The mammalian zona pellucida, which mediates species-specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.  
  • CuratedUniProtKB
GO molecular function 
Acrosin bindingdefinition[GO:0032190]  
1
  • IPIUniProtKB
Carbohydrate bindingdefinition[GO:0030246]  
1
  • IDAUniProtKB
Manganese ion transmembrane transporter activitydefinition[GO:0005384]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Signal transducer activitydefinition[GO:0004871]  
1
  • IMPUniProtKB
Store-operated calcium channel activitydefinition[GO:0015279]  
1
  • IDAUniProtKB
GO biological process 
Binding of sperm to zona pellucidadefinition[GO:0007339]  
4
  • IDAUniProtKB
Blastocyst formationdefinition[GO:0001825]  
  • ISSOrtholog Curator
Calcium ion transmembrane transportdefinition[GO:0070588]  
1
  • IDAGOC
Egg coat formationdefinition[GO:0035803]  
  • ISSOrtholog Curator
Humoral immune response mediated by circulating immunoglobulindefinition[GO:0002455]  
  • ISSOrtholog Curator
Intracellular protein transportdefinition[GO:0006886]  
  • ISSOrtholog Curator
Intracellular signal transductiondefinition[GO:0035556]  
1
  • IMPUniProtKB
Manganese ion transmembrane transportdefinition[GO:0071421]  
  • ISSOrtholog Curator
Manganese ion transportdefinition[GO:0006828]  
  • ISSOrtholog Curator
Negative regulation of binding of sperm to zona pellucidadefinition[GO:2000360]  
1
  • IDAUniProtKB
Negative regulation of transcription, DNA-templateddefinition[GO:0045892]  
  • ISSOrtholog Curator
Oocyte developmentdefinition[GO:0048599]  
  • ISSOrtholog Curator
Phosphatidylinositol-mediated signalingdefinition[GO:0048015]  
  • ISSOrtholog Curator
Positive regulation of acrosomal vesicle exocytosisdefinition[GO:2000368]  
2
  • IDAUniProtKB
Positive regulation of acrosome reactiondefinition[GO:2000344]  
3
  • IDAUniProtKB
Positive regulation of antral ovarian follicle growthdefinition[GO:2000388]  
  • ISSOrtholog Curator
Positive regulation of calcium ion importdefinition[GO:0090280]  
1
  • IDAUniProtKB
Positive regulation of humoral immune responsedefinition[GO:0002922]  
1
  • IDAUniProtKB
Positive regulation of inflammatory responsedefinition[GO:0050729]  
  • ISSOrtholog Curator
Positive regulation of interferon-gamma productiondefinition[GO:0032729]  
  • ISSOrtholog Curator
Positive regulation of interleukin-4 productiondefinition[GO:0032753]  
  • ISSOrtholog Curator
Positive regulation of leukocyte migrationdefinition[GO:0002687]  
  • ISSOrtholog Curator
Positive regulation of ovarian follicle developmentdefinition[GO:2000386]  
  • ISSOrtholog Curator
Positive regulation of phosphatidylinositol biosynthetic processdefinition[GO:0010513]  
  • ISSOrtholog Curator
Positive regulation of protein kinase activitydefinition[GO:0045860]  
1
  • IDAUniProtKB
Positive regulation of protein kinase B signalingdefinition[GO:0051897]  
  • ISSOrtholog Curator
Positive regulation of T cell proliferationdefinition[GO:0042102]  
  • ISSOrtholog Curator
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
  • ISSOrtholog Curator
Positive regulation of type IV hypersensitivitydefinition[GO:0001809]  
  • ISSOrtholog Curator
Protein kinase C signalingdefinition[GO:0070528]  
1
  • IMPUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Reproduction  REACT_163848  
 

Keywords

Biological process 
Fertilization  definition   [KW-0278]
Molecular function 
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ZP3
GenomeRNAi: 7784
PRO: PR:P21754