FGFR2 - Fibroblast growth factor receptor 2 - human protein (Function)
 
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FGFR2 »  Fibroblast growth factor receptor 2   [ EC 2.7.10.1 ]  (FGFR-2)
 
Protein also known as:  Keratinocyte growth factor receptor; CD antigen CD332.
Gene name:  FGFR2
Entry whose protein(s) existence is based on evidence at protein level
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1 142 23
GENE REF ISO

Function

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Overview 
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.  
14
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Fibroblast growth factor bindingdefinition[GO:0017134]  
4
  • UniProtKB
  • MGI
Fibroblast growth factor-activated receptor activitydefinition[GO:0005007]  
6
  • UniProtKB
  • MGI
Heparin bindingdefinition[GO:0008201]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
9
  • IntAct
Protein homodimerization activitydefinition[GO:0042803]  
1
  • UniProtKB
Protein tyrosine kinase activitydefinition[GO:0004713]  
1
  • UniProtKB
GO biological process 
Angiogenesisdefinition[GO:0001525]  
1
  • Ortholog Curator
Apoptotic processdefinition[GO:0006915]  
1
  • UniProtKB KW
Axonogenesisdefinition[GO:0007409]  
1
  • Ortholog Curator
Bone developmentdefinition[GO:0060348]  
1
  • Ortholog Curator
Bone mineralizationdefinition[GO:0030282]  
1
  • Ortholog Curator
Bone morphogenesisdefinition[GO:0060349]  
1
  • Ortholog Curator
Branch elongation involved in salivary gland morphogenesisdefinition[GO:0060667]  
1
  • Ortholog Curator
Branching involved in labyrinthine layer morphogenesisdefinition[GO:0060670]  
1
  • Ortholog Curator
Branching involved in prostate gland morphogenesisdefinition[GO:0060442]  
1
  • Ortholog Curator
Branching involved in salivary gland morphogenesisdefinition[GO:0060445]  
1
  • Ortholog Curator
Branching morphogenesis of a nervedefinition[GO:0048755]  
1
  • Ortholog Curator
Bud elongation involved in lung branchingdefinition[GO:0060449]  
1
  • Ortholog Curator
Cell fate commitmentdefinition[GO:0045165]  
1
  • Ortholog Curator
Cell-cell signalingdefinition[GO:0007267]  
1
  • Ortholog Curator
Coronal suture morphogenesisdefinition[GO:0060365] silver  
1
  • Ortholog Compara
Digestive tract developmentdefinition[GO:0048565]  
1
  • Ortholog Curator
Embryonic cranial skeleton morphogenesisdefinition[GO:0048701]  
2
  • BHF-UCL
Embryonic digestive tract morphogenesisdefinition[GO:0048557]  
1
  • Ortholog Curator
Embryonic organ developmentdefinition[GO:0048568]  
1
  • Ortholog Curator
Embryonic organ morphogenesisdefinition[GO:0048562]  
1
  • Ortholog Curator
Embryonic pattern specificationdefinition[GO:0009880]  
1
  • Ortholog Curator
Endodermal digestive tract morphogenesisdefinition[GO:0061031] silver  
1
  • Ortholog Compara
Epidermis morphogenesisdefinition[GO:0048730]  
1
  • Ortholog Curator
Epithelial cell differentiationdefinition[GO:0030855]  
1
  • Ortholog Curator
Epithelial cell proliferation involved in salivary gland morphogenesisdefinition[GO:0060664]  
1
  • Ortholog Curator
Epithelial to mesenchymal transitiondefinition[GO:0001837] silver  
1
  • Ortholog Compara
Fibroblast growth factor receptor signaling pathwaydefinition[GO:0008543]  
4
  • UniProtKB
  • MGI
Fibroblast growth factor receptor signaling pathway involved in hemopoiesisdefinition[GO:0035603]  
1
  • Ortholog Curator
Fibroblast growth factor receptor signaling pathway involved in mammary gland specificationdefinition[GO:0060595]  
1
  • Ortholog Curator
Fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrowdefinition[GO:0035602]  
1
  • Ortholog Curator
Fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentdefinition[GO:0035607]  
1
  • Ortholog Curator
Fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrowdefinition[GO:0035604]  
1
  • Ortholog Curator
Gland morphogenesisdefinition[GO:0022612]  
1
  • Ortholog Curator
Hair follicle morphogenesisdefinition[GO:0031069]  
1
  • Ortholog Curator
In utero embryonic developmentdefinition[GO:0001701]  
1
  • Ortholog Curator
Inner ear morphogenesisdefinition[GO:0042472]  
1
  • Ortholog Curator
Lacrimal gland developmentdefinition[GO:0032808]  
1
  • Ortholog Curator
Lateral sprouting from an epitheliumdefinition[GO:0060601]  
1
  • Ortholog Curator
Lens fiber cell developmentdefinition[GO:0070307] silver  
1
  • Ortholog Compara
Limb bud formationdefinition[GO:0060174]  
1
  • Ortholog Curator
Lung alveolus developmentdefinition[GO:0048286]  
1
  • Ortholog Curator
Lung developmentdefinition[GO:0030324]  
1
  • Ortholog Curator
Lung lobe morphogenesisdefinition[GO:0060463]  
1
  • Ortholog Curator
Lung-associated mesenchyme developmentdefinition[GO:0060484]  
1
  • Ortholog Curator
Mammary gland bud formationdefinition[GO:0060615]  
1
  • Ortholog Curator
Membranous septum morphogenesisdefinition[GO:0003149]  
1
  • Ortholog Curator
Mesenchymal cell differentiationdefinition[GO:0048762]  
1
  • Ortholog Curator
Mesenchymal cell differentiation involved in lung developmentdefinition[GO:0060915]  
1
  • Ortholog Curator
Mesenchymal cell proliferation involved in lung developmentdefinition[GO:0060916]  
1
  • Ortholog Curator
Mesodermal cell differentiationdefinition[GO:0048333] silver  
1
  • Ortholog Compara
Midbrain developmentdefinition[GO:0030901]  
1
  • Ortholog Curator
Morphogenesis of embryonic epitheliumdefinition[GO:0016331]  
1
  • Ortholog Curator
Multicellular organism growthdefinition[GO:0035264]  
1
  • Ortholog Curator
Negative regulation of epithelial cell proliferationdefinition[GO:0050680] silver  
1
  • Ortholog Compara
Negative regulation of mitosisdefinition[GO:0045839] silver  
1
  • Ortholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
1
  • Ortholog Curator
Neuromuscular junction developmentdefinition[GO:0007528] silver  
1
  • Ortholog Compara
Odontogenesisdefinition[GO:0042476]  
1
  • Ortholog Curator
Orbitofrontal cortex developmentdefinition[GO:0021769]  
1
  • Ortholog Curator
Organ growthdefinition[GO:0035265]  
1
  • Ortholog Curator
Organ morphogenesisdefinition[GO:0009887]  
1
  • Ortholog Curator
Otic vesicle formationdefinition[GO:0030916]  
1
  • Ortholog Curator
Outflow tract septum morphogenesisdefinition[GO:0003148]  
1
  • Ortholog Curator
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
2
  • UniProtKB
Positive regulation of canonical Wnt signaling pathwaydefinition[GO:0090263]  
1
  • Ortholog Curator
Positive regulation of cardiac muscle cell proliferationdefinition[GO:0060045]  
1
  • Ortholog Curator
Positive regulation of cell cycledefinition[GO:0045787]  
1
  • Ortholog Curator
Positive regulation of cell divisiondefinition[GO:0051781]  
1
  • Ortholog Curator
Positive regulation of cell proliferationdefinition[GO:0008284]  
3
  • UniProtKB
  • MGI
Positive regulation of epithelial cell proliferationdefinition[GO:0050679]  
1
  • Ortholog Curator
Positive regulation of epithelial cell proliferation involved in lung morphogenesisdefinition[GO:0060501]  
1
  • Ortholog Curator
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • Ortholog Curator
Positive regulation of MAPK cascadedefinition[GO:0043410]  
1
  • UniProtKB
Positive regulation of mesenchymal cell proliferationdefinition[GO:0002053]  
1
  • Ortholog Curator
Positive regulation of phospholipase activitydefinition[GO:0010518]  
1
  • UniProtKB
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661] silver  
1
  • Ortholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • Ortholog Curator
Positive regulation of Wnt signaling pathwaydefinition[GO:0030177]  
1
  • Ortholog Curator
Post-embryonic developmentdefinition[GO:0009791]  
1
  • Ortholog Curator
Prostate epithelial cord arborization involved in prostate glandular acinus morphogenesisdefinition[GO:0060527]  
1
  • Ortholog Curator
Prostate epithelial cord elongationdefinition[GO:0060523]  
1
  • Ortholog Curator
Prostate gland morphogenesisdefinition[GO:0060512]  
1
  • Ortholog Curator
Protein autophosphorylationdefinition[GO:0046777]  
1
  • UniProtKB
Pyramidal neuron developmentdefinition[GO:0021860]  
1
  • Ortholog Curator
Regulation of branching involved in prostate gland morphogenesisdefinition[GO:0060687]  
1
  • Ortholog Curator
Regulation of cell fate commitmentdefinition[GO:0010453]  
1
  • Ortholog Curator
Regulation of ERK1 and ERK2 cascadedefinition[GO:0070372]  
1
  • Ortholog Curator
Regulation of fibroblast growth factor receptor signaling pathwaydefinition[GO:0040036]  
1
  • Ortholog Curator
Regulation of morphogenesis of a branching structuredefinition[GO:0060688]  
1
  • Ortholog Curator
Regulation of multicellular organism growthdefinition[GO:0040014]  
1
  • Ortholog Curator
Regulation of osteoblast differentiationdefinition[GO:0045667]  
1
  • UniProtKB
Regulation of osteoblast proliferationdefinition[GO:0033688]  
1
  • UniProtKB
Regulation of smooth muscle cell differentiationdefinition[GO:0051150]  
1
  • Ortholog Curator
Regulation of smoothened signaling pathwaydefinition[GO:0008589]  
1
  • Ortholog Curator
Reproductive structure developmentdefinition[GO:0048608]  
1
  • Ortholog Curator
Skeletal system morphogenesisdefinition[GO:0048705]  
1
  • UniProtKB
Squamous basal epithelial stem cell differentiation involved in prostate gland acinus developmentdefinition[GO:0060529]  
1
  • Ortholog Curator
Synaptic vesicle transportdefinition[GO:0048489] silver  
1
  • Ortholog Compara
Ureteric bud developmentdefinition[GO:0001657]  
1
  • Ortholog Curator
Ventricular cardiac muscle tissue morphogenesisdefinition[GO:0055010]  
1
  • Ortholog Curator
Ventricular zone neuroblast divisiondefinition[GO:0021847]  
1
  • Ortholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
6
  • UniProtKB
  • PROSITE-ProRule
It is regulated in the following manner
Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by ARQ 523 and ARQ 069; these compounds maintain the kinase in an inactive conformation and inhibit autophosphorylation.  
3
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Endocytosis  hsa04144+2263  
MAPK signaling pathway  hsa04010+2263  
Pathways in cancer  hsa05200+2263  
Prostate cancer  hsa05215+2263  
Regulation of actin cytoskeleton  hsa04810+2263  
According to Reactome, this protein belongs to the following pathways:
Activated point mutants of FGFR2  REACT_120863  
Constitutive PI3K/AKT Signaling in Cancer  REACT_147727  
FGFR2b ligand binding and activation  REACT_9416  
FGFR2c ligand binding and activation  REACT_9413  
FRS2-mediated cascade  REACT_21247  
Negative regulation of FGFR signaling  REACT_111184  
Phospholipase C-mediated cascade  REACT_21310  
PI-3K cascade  REACT_21270  
PI3K Cascade  REACT_976  
PIP3 activates AKT signaling  REACT_75829  
SHC-mediated cascade  REACT_21374  
Signaling by FGFR mutants  REACT_121398  
Signaling by FGFR2 amplification mutants  REACT_121255  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Fibroblast_growth_factor_receptor_2
GenomeRNAi: 2263
PRO: PR:P21802
Chemistry
GuidetoPHARMACOLOGY: 1809