FGFR2 - Fibroblast growth factor receptor 2 - human protein (Function)
 
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FGFR2 »  Fibroblast growth factor receptor 2   [ EC 2.7.10.1 ]  (FGFR-2)
 
Protein also known as:  Keratinocyte growth factor receptor; CD antigen CD332.
Gene name:  FGFR2
Entry whose protein(s) existence is based on evidence at protein level
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1 137 23
GENE REF ISO

Function

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Overview 
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.  
15
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Fibroblast growth factor bindingdefinition[GO:0017134]  
4
  • IPIUniProtKB
  • IPIMGI
Fibroblast growth factor-activated receptor activitydefinition[GO:0005007]  
6
  • IDAUniProtKB
  • IGIMGI
Heparin bindingdefinition[GO:0008201]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
7
  • IPIIntAct
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIUniProtKB
Protein tyrosine kinase activitydefinition[GO:0004713]  
1
  • NASUniProtKB
GO biological process 
Angiogenesisdefinition[GO:0001525]  
  • ISSOrtholog Curator
Apoptotic processdefinition[GO:0006915]  
  • IEAUniProtKB KW
Axonogenesisdefinition[GO:0007409]  
  • ISSOrtholog Curator
Bone developmentdefinition[GO:0060348]  
  • ISSOrtholog Curator
Bone mineralizationdefinition[GO:0030282]  
  • ISSOrtholog Curator
Bone morphogenesisdefinition[GO:0060349]  
  • ISSOrtholog Curator
Branch elongation involved in salivary gland morphogenesisdefinition[GO:0060667]  
  • ISSOrtholog Curator
Branching involved in labyrinthine layer morphogenesisdefinition[GO:0060670]  
  • ISSOrtholog Curator
Branching involved in prostate gland morphogenesisdefinition[GO:0060442]  
  • ISSOrtholog Curator
Branching involved in salivary gland morphogenesisdefinition[GO:0060445]  
  • ISSOrtholog Curator
Branching morphogenesis of a nervedefinition[GO:0048755]  
  • ISSOrtholog Curator
Bud elongation involved in lung branchingdefinition[GO:0060449]  
  • ISSOrtholog Curator
Cell fate commitmentdefinition[GO:0045165]  
  • ISSOrtholog Curator
Cell-cell signalingdefinition[GO:0007267]  
  • ISSOrtholog Curator
Coronal suture morphogenesisdefinition[GO:0060365] silver  
  • IEAOrtholog Compara
Digestive tract developmentdefinition[GO:0048565]  
  • ISSOrtholog Curator
Embryonic cranial skeleton morphogenesisdefinition[GO:0048701]  
2
  • IMPBHF-UCL
Embryonic digestive tract morphogenesisdefinition[GO:0048557]  
  • ISSOrtholog Curator
Embryonic organ developmentdefinition[GO:0048568]  
  • ISSOrtholog Curator
Embryonic organ morphogenesisdefinition[GO:0048562]  
  • ISSOrtholog Curator
Embryonic pattern specificationdefinition[GO:0009880]  
  • ISSOrtholog Curator
Endodermal digestive tract morphogenesisdefinition[GO:0061031] silver  
  • IEAOrtholog Compara
Epidermis morphogenesisdefinition[GO:0048730]  
  • ISSOrtholog Curator
Epithelial cell differentiationdefinition[GO:0030855]  
  • ISSOrtholog Curator
Epithelial cell proliferation involved in salivary gland morphogenesisdefinition[GO:0060664]  
  • ISSOrtholog Curator
Epithelial to mesenchymal transitiondefinition[GO:0001837] silver  
  • IEAOrtholog Compara
Fibroblast growth factor receptor signaling pathwaydefinition[GO:0008543]  
4
  • IDAUniProtKB
  • IPIMGI
Fibroblast growth factor receptor signaling pathway involved in hemopoiesisdefinition[GO:0035603]  
  • ISSOrtholog Curator
Fibroblast growth factor receptor signaling pathway involved in mammary gland specificationdefinition[GO:0060595]  
  • ISSOrtholog Curator
Fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrowdefinition[GO:0035602]  
  • ISSOrtholog Curator
Fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex developmentdefinition[GO:0035607]  
  • ISSOrtholog Curator
Fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrowdefinition[GO:0035604]  
  • ISSOrtholog Curator
Gland morphogenesisdefinition[GO:0022612]  
  • ISSOrtholog Curator
Hair follicle morphogenesisdefinition[GO:0031069]  
  • ISSOrtholog Curator
In utero embryonic developmentdefinition[GO:0001701]  
  • ISSOrtholog Curator
Inner ear morphogenesisdefinition[GO:0042472]  
  • ISSOrtholog Curator
Lacrimal gland developmentdefinition[GO:0032808]  
  • ISSOrtholog Curator
Lateral sprouting from an epitheliumdefinition[GO:0060601]  
  • ISSOrtholog Curator
Lens fiber cell developmentdefinition[GO:0070307] silver  
  • IEAOrtholog Compara
Limb bud formationdefinition[GO:0060174]  
  • ISSOrtholog Curator
Lung alveolus developmentdefinition[GO:0048286]  
  • ISSOrtholog Curator
Lung developmentdefinition[GO:0030324]  
  • ISSOrtholog Curator
Lung lobe morphogenesisdefinition[GO:0060463]  
  • ISSOrtholog Curator
Lung-associated mesenchyme developmentdefinition[GO:0060484]  
  • ISSOrtholog Curator
Mammary gland bud formationdefinition[GO:0060615]  
  • ISSOrtholog Curator
Membranous septum morphogenesisdefinition[GO:0003149]  
  • ISSOrtholog Curator
Mesenchymal cell differentiationdefinition[GO:0048762]  
  • ISSOrtholog Curator
Mesenchymal cell differentiation involved in lung developmentdefinition[GO:0060915]  
  • ISSOrtholog Curator
Mesenchymal cell proliferation involved in lung developmentdefinition[GO:0060916]  
  • ISSOrtholog Curator
Mesodermal cell differentiationdefinition[GO:0048333] silver  
  • IEAOrtholog Compara
Midbrain developmentdefinition[GO:0030901]  
  • ISSOrtholog Curator
Morphogenesis of embryonic epitheliumdefinition[GO:0016331]  
  • ISSOrtholog Curator
Multicellular organism growthdefinition[GO:0035264]  
  • ISSOrtholog Curator
Negative regulation of epithelial cell proliferationdefinition[GO:0050680] silver  
  • IEAOrtholog Compara
Negative regulation of mitosisdefinition[GO:0045839] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122]  
  • ISSOrtholog Curator
Neuromuscular junction developmentdefinition[GO:0007528] silver  
  • IEAOrtholog Compara
Odontogenesisdefinition[GO:0042476]  
  • ISSOrtholog Curator
Orbitofrontal cortex developmentdefinition[GO:0021769]  
  • ISSOrtholog Curator
Organ growthdefinition[GO:0035265]  
  • ISSOrtholog Curator
Organ morphogenesisdefinition[GO:0009887]  
  • ISSOrtholog Curator
Otic vesicle formationdefinition[GO:0030916]  
  • ISSOrtholog Curator
Outflow tract septum morphogenesisdefinition[GO:0003148]  
  • ISSOrtholog Curator
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
2
  • IDAUniProtKB
Positive regulation of canonical Wnt signaling pathwaydefinition[GO:0090263]  
  • ISSOrtholog Curator
Positive regulation of cardiac muscle cell proliferationdefinition[GO:0060045]  
  • ISSOrtholog Curator
Positive regulation of cell cycledefinition[GO:0045787]  
  • ISSOrtholog Curator
Positive regulation of cell divisiondefinition[GO:0051781]  
  • ISSOrtholog Curator
Positive regulation of cell proliferationdefinition[GO:0008284]  
3
  • IMPUniProtKB
  • IGIMGI
Positive regulation of epithelial cell proliferationdefinition[GO:0050679]  
  • ISSOrtholog Curator
Positive regulation of epithelial cell proliferation involved in lung morphogenesisdefinition[GO:0060501]  
  • ISSOrtholog Curator
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
  • ISSOrtholog Curator
Positive regulation of MAPK cascadedefinition[GO:0043410]  
1
  • IMPUniProtKB
Positive regulation of mesenchymal cell proliferationdefinition[GO:0002053]  
  • ISSOrtholog Curator
Positive regulation of phospholipase activitydefinition[GO:0010518]  
1
  • IMPUniProtKB
Positive regulation of smooth muscle cell proliferationdefinition[GO:0048661] silver  
  • IEAOrtholog Compara
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
  • ISSOrtholog Curator
Positive regulation of Wnt signaling pathwaydefinition[GO:0030177]  
  • ISSOrtholog Curator
Post-embryonic developmentdefinition[GO:0009791]  
  • ISSOrtholog Curator
Prostate epithelial cord arborization involved in prostate glandular acinus morphogenesisdefinition[GO:0060527]  
  • ISSOrtholog Curator
Prostate epithelial cord elongationdefinition[GO:0060523]  
  • ISSOrtholog Curator
Prostate gland morphogenesisdefinition[GO:0060512]  
  • ISSOrtholog Curator
Protein autophosphorylationdefinition[GO:0046777]  
1
  • IDAUniProtKB
Pyramidal neuron developmentdefinition[GO:0021860]  
  • ISSOrtholog Curator
Regulation of branching involved in prostate gland morphogenesisdefinition[GO:0060687]  
  • ISSOrtholog Curator
Regulation of cell fate commitmentdefinition[GO:0010453]  
  • ISSOrtholog Curator
Regulation of ERK1 and ERK2 cascadedefinition[GO:0070372]  
  • ISSOrtholog Curator
Regulation of fibroblast growth factor receptor signaling pathwaydefinition[GO:0040036]  
  • ISSOrtholog Curator
Regulation of morphogenesis of a branching structuredefinition[GO:0060688]  
  • ISSOrtholog Curator
Regulation of multicellular organism growthdefinition[GO:0040014]  
  • ISSOrtholog Curator
Regulation of osteoblast differentiationdefinition[GO:0045667]  
1
  • TASUniProtKB
Regulation of osteoblast proliferationdefinition[GO:0033688]  
1
  • TASUniProtKB
Regulation of smooth muscle cell differentiationdefinition[GO:0051150]  
  • ISSOrtholog Curator
Regulation of smoothened signaling pathwaydefinition[GO:0008589]  
  • ISSOrtholog Curator
Reproductive structure developmentdefinition[GO:0048608]  
  • ISSOrtholog Curator
Skeletal system morphogenesisdefinition[GO:0048705]  
1
  • TASUniProtKB
Squamous basal epithelial stem cell differentiation involved in prostate gland acinus developmentdefinition[GO:0060529]  
  • ISSOrtholog Curator
Synaptic vesicle transportdefinition[GO:0048489] silver  
  • IEAOrtholog Compara
Ureteric bud developmentdefinition[GO:0001657]  
  • ISSOrtholog Curator
Ventricular cardiac muscle tissue morphogenesisdefinition[GO:0055010]  
  • ISSOrtholog Curator
Ventricular zone neuroblast divisiondefinition[GO:0021847]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
4
  • CuratedUniProtKB
It is regulated in the following manner
Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by ARQ 523 and ARQ 069; these compounds maintain the kinase in an inactive conformation and inhibit autophosphorylation.  
2
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Endocytosis  hsa04144+2263  
MAPK signaling pathway  hsa04010+2263  
Pathways in cancer  hsa05200+2263  
Prostate cancer  hsa05215+2263  
Regulation of actin cytoskeleton  hsa04810+2263  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Immune System  REACT_6900  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Fibroblast_growth_factor_receptor_2
GenomeRNAi: 2263
PRO: PR:P21802
Chemistry
GuidetoPHARMACOLOGY: 1809