BGN - Biglycan - human protein (Function)
 
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Protein
Gene
References

 
BGN »  Biglycan
 
Protein also known as:  Bone/cartilage proteoglycan I.
Gene name:  BGN
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
May be involved in collagen fiber assembly.  
1
  • UniProtKB
GO molecular function 
Extracellular matrix bindingdefinition[GO:0050840] silver  
1
  • Ortholog Compara
Extracellular matrix structural constituentdefinition[GO:0005201]  
1
  • UniProtKB
Glycosaminoglycan bindingdefinition[GO:0005539] silver  
1
  • Ortholog Compara
GO biological process 
Blood vessel remodelingdefinition[GO:0001974] silver  
1
  • Ortholog Compara
Peptide cross-linking via chondroitin 4-sulfate glycosaminoglycandefinition[GO:0019800] silver  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
A tetrasaccharide linker sequence is required for GAG synthesis  R-HSA-1971475  
Chondroitin sulfate biosynthesis  R-HSA-2022870  
CS/DS degradation  R-HSA-2024101  
Defective B3GAT3 causes JDSSDHD  R-HSA-3560801  
Defective B4GALT7 causes EDS, progeroid type  R-HSA-3560783  
Defective CHST14 causes EDS, musculocontractural type  R-HSA-3595174  
Defective CHST3 causes SEDCJD  R-HSA-3595172  
Defective CHSY1 causes TPBS  R-HSA-3595177  
Dermatan sulfate biosynthesis  R-HSA-2022923  
ECM proteoglycans  R-HSA-3000178  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Biglycan
GenomeRNAi: 633
PRO: PR:P21810