ERBB3 - Receptor tyrosine-protein kinase erbB-3 - human protein (Function)
 
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ERBB3 »  Receptor tyrosine-protein kinase erbB-3   [ EC 2.7.10.1 ]
 
Protein also known as:  Tyrosine kinase-type cell surface receptor HER3.
Gene name:  ERBB3
Entry whose protein(s) existence is based on evidence at protein level
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1 249 5
GENE REF ISO

Function

 show evidences
Overview 
Binds and is activated by neuregulins and NTAK.  
1
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Growth factor bindingdefinition[GO:0019838]  
2
  • IPIBHF-UCL
Protein bindingdefinition[GO:0005515]  
16
  • IPIIntAct
Protein heterodimerization activitydefinition[GO:0046982]  
2
  • IDAUniProtKB
  • IPIBHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • NASBHF-UCL
Protein tyrosine kinase activator activitydefinition[GO:0030296]  
1
  • IDABHF-UCL
Not  Protein tyrosine kinase activitydefinition[GO:0004713]  
1
  • IDABHF-UCL
Transmembrane signaling receptor activitydefinition[GO:0004888]  
1
  • ISSBHF-UCL
GO biological process 
Cranial nerve developmentdefinition[GO:0021545]  
  • ISSOrtholog Curator
Endocardial cushion developmentdefinition[GO:0003197] silver  
  • IEAOrtholog Compara
Extrinsic apoptotic signaling pathway in absence of liganddefinition[GO:0097192]  
1
  • IMPBHF-UCL
Heart developmentdefinition[GO:0007507]  
  • ISSOrtholog Curator
Negative regulation of cell adhesiondefinition[GO:0007162]  
1
  • IDABHF-UCL
Negative regulation of neuron apoptotic processdefinition[GO:0043524]  
  • ISSOrtholog Curator
Negative regulation of secretiondefinition[GO:0051048]  
1
  • IDABHF-UCL
Negative regulation of signal transductiondefinition[GO:0009968]  
1
  • IDABHF-UCL
Neuron apoptotic processdefinition[GO:0051402]  
1
  • IMPBHF-UCL
Peripheral nervous system developmentdefinition[GO:0007422]  
  • ISSOrtholog Curator
Phosphatidylinositol 3-kinase signalingdefinition[GO:0014065]  
1
  • IDABHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signalingdefinition[GO:0014068]  
1
  • TASBHF-UCL
Positive regulation of protein tyrosine kinase activitydefinition[GO:0061098]  
1
  • IMPBHF-UCL
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • IDABHF-UCL
Schwann cell differentiationdefinition[GO:0014037]  
  • ISSOrtholog Curator
Signal transductiondefinition[GO:0007165]  
1
  • IDAUniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathwaydefinition[GO:0007169]  
1
  • ISSBHF-UCL
Wound healingdefinition[GO:0042060]  
1
  • NASBHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
1
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+2065  
Endocytosis  hsa04144+2065  
ErbB signaling pathway  hsa04012+2065  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Immune System  REACT_6900  
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: ERBB3
GenomeRNAi: 2065
PRO: PR:P21860
Chemistry
GuidetoPHARMACOLOGY: 1798