SDHB - Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial - human protein (Function)
 
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SDHB »  Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial   [ EC 1.3.5.1 ]
 
Protein also known as:  Iron-sulfur subunit of complex II (Ip).
Gene name:  SDHB
Entry whose protein(s) existence is based on evidence at protein level
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1 109 1
GENE REF ISO

Function

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Overview 
Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).  
  • CuratedUniProtKB
GO molecular function 
2 iron, 2 sulfur cluster bindingdefinition[GO:0051537]  
  • ISSOrtholog Curator
3 iron, 4 sulfur cluster bindingdefinition[GO:0051538]  
  • ISSOrtholog Curator
4 iron, 4 sulfur cluster bindingdefinition[GO:0051539]  
  • ISSOrtholog Curator
Electron carrier activitydefinition[GO:0009055] silver  
  • IEAInterPro 2 GO
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
  • IPIUniProtKB
Succinate dehydrogenase (ubiquinone) activitydefinition[GO:0008177]  
  • IEAEC 2 GO
Ubiquinone bindingdefinition[GO:0048039]  
  • ISSOrtholog Curator
GO biological process 
Aerobic respirationdefinition[GO:0009060]  
1
  • TASPINC
Succinate metabolic processdefinition[GO:0006105] silver  
  • IEAOrtholog Compara
Tricarboxylic acid cycledefinition[GO:0006099]  
  • IEAUniPathway
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 1.3.5.1: Succinate + a quinone fumarate + a quinol.  
  • CuratedUniProtKB
It requires the following cofactors
Binds 1 2Fe-2S cluster (By similarity).  
  • CuratedUniProtKB
Binds 1 3Fe-4S cluster (By similarity).  
  • CuratedUniProtKB
Binds 1 4Fe-4S cluster (By similarity).  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Alzheimer's disease  hsa05010+6390  
Citrate cycle (TCA cycle)  hsa00020+6390  
Huntington's disease  hsa05016+6390  
Metabolic pathways  hsa01100+6390  
Oxidative phosphorylation  hsa00190+6390  
Parkinson's disease  hsa05012+6390  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Electron transport  definition   [KW-0249]
Transport  definition   [KW-0813]
Tricarboxylic acid cycle  definition   [KW-0816]
Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: SDHB
GenomeRNAi: 6390
PRO: PR:P21912