DRD4 - D(4) dopamine receptor - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
DRD4 »  D(4) dopamine receptor
 
Protein also known as:  D(2C) dopamine receptor.
Gene name:  DRD4
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 285 1
GENE REF ISO

Function

 show evidences
Overview 
Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase. Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity).  
1
  • UniProtKB
GO molecular function 
Dopamine bindingdefinition[GO:0035240]  
1
  • BHF-UCL
Dopamine neurotransmitter receptor activitydefinition[GO:0004952]  
1
  • BHF-UCL
Dopamine neurotransmitter receptor activity, coupled via Gi/Godefinition[GO:0001591]  
2
  • BHF-UCL
  • Ortholog Curator
Drug bindingdefinition[GO:0008144]  
3
  • BHF-UCL
G-protein coupled amine receptor activitydefinition[GO:0008227]  
1
  • RefGenome
Identical protein bindingdefinition[GO:0042802]  
1
  • IntAct
Potassium channel regulator activitydefinition[GO:0015459]  
1
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • BHF-UCL
SH3 domain bindingdefinition[GO:0017124]  
1
  • BHF-UCL
GO biological process 
Activation of MAPK activitydefinition[GO:0000187]  
2
  • BHF-UCL
Adenylate cyclase-inhibiting dopamine receptor signaling pathwaydefinition[GO:0007195]  
1
  • BHF-UCL
Adult locomotory behaviordefinition[GO:0008344]  
1
  • Ortholog Curator
Arachidonic acid secretiondefinition[GO:0050482]  
1
  • BHF-UCL
Behavioral fear responsedefinition[GO:0001662]  
1
  • BHF-UCL
Behavioral response to cocainedefinition[GO:0048148]  
1
  • Ortholog Curator
Behavioral response to ethanoldefinition[GO:0048149]  
1
  • BHF-UCL
Cellular calcium ion homeostasisdefinition[GO:0006874]  
1
  • BHF-UCL
Circadian rhythmdefinition[GO:0007623] silver  
1
  • Ortholog Compara
Dopamine metabolic processdefinition[GO:0042417]  
1
  • BHF-UCL
Dopamine receptor signaling pathwaydefinition[GO:0007212]  
1
  • BHF-UCL
Fear responsedefinition[GO:0042596]  
1
  • Ortholog Curator
Negative regulation of adenylate cyclase activitydefinition[GO:0007194]  
1
  • BHF-UCL
Negative regulation of cAMP biosynthetic processdefinition[GO:0030818]  
2
  • BHF-UCL
Negative regulation of protein secretiondefinition[GO:0050709]  
1
  • BHF-UCL
Negative regulation of voltage-gated calcium channel activitydefinition[GO:1901386]  
1
  • BHF-UCL
Olfactory learningdefinition[GO:0008355] silver  
1
  • Ortholog Compara
Photoperiodismdefinition[GO:0009648] silver  
1
  • Ortholog Compara
Not  Positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwaydefinition[GO:0010579]  
1
  • RefGenome
Positive regulation of dopamine uptake involved in synaptic transmissiondefinition[GO:0051586]  
1
  • BHF-UCL
Positive regulation of excitatory postsynaptic membrane potentialdefinition[GO:2000463] silver  
1
  • Ortholog Compara
Positive regulation of kinase activitydefinition[GO:0033674]  
1
  • BHF-UCL
Positive regulation of penile erectiondefinition[GO:0060406] silver  
1
  • Ortholog Compara
Positive regulation of sodium:proton antiporter activitydefinition[GO:0032417]  
1
  • BHF-UCL
Regulation of calcium-mediated signalingdefinition[GO:0050848] silver  
1
  • Ortholog Compara
Regulation of circadian rhythmdefinition[GO:0042752]  
1
  • Ortholog Curator
Regulation of dopamine metabolic processdefinition[GO:0042053]  
1
  • Ortholog Curator
Regulation of inhibitory postsynaptic membrane potentialdefinition[GO:0060080]  
1
  • Ortholog Curator
Regulation of neurotransmitter secretiondefinition[GO:0046928] silver  
1
  • Ortholog Compara
Response to amphetaminedefinition[GO:0001975]  
1
  • Ortholog Curator
Response to histaminedefinition[GO:0034776]  
1
  • BHF-UCL
Response to steroid hormonedefinition[GO:0048545] silver  
1
  • Ortholog Compara
Retina development in camera-type eyedefinition[GO:0060041] silver  
1
  • Ortholog Compara
Sensory perception of chemical stimulusdefinition[GO:0007606]  
1
  • RefGenome
Short-term memorydefinition[GO:0007614] silver  
1
  • Ortholog Compara
Social behaviordefinition[GO:0035176]  
2
  • BHF-UCL
Synaptic transmissiondefinition[GO:0007268]  
1
  • RefGenome
Synaptic transmission, dopaminergicdefinition[GO:0001963] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Dopaminergic synapse  hsa04728+1815  
Neuroactive ligand-receptor interaction  hsa04080+1815  
According to Reactome, this protein belongs to the following pathways:
Dopamine receptors  REACT_16968  
G alpha (i) signalling events  REACT_19231  
 

Keywords

Biological process 
Biological rhythms  definition   [KW-0090]
Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Dopamine_receptor_D4
GenomeRNAi: 1815
PRO: PR:P21917
Chemistry
GuidetoPHARMACOLOGY: 217