DRD4 - D(4) dopamine receptor - human protein (Function)
 
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DRD4 »  D(4) dopamine receptor
 
Protein also known as:  D(2C) dopamine receptor.
Gene name:  DRD4
Entry whose protein(s) existence is based on evidence at protein level
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1 260 1
GENE REF ISO

Function

 show evidences
Overview 
Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Its activity is mediated by G proteins which inhibit adenylyl cyclase.  
  • CuratedUniProtKB
GO molecular function 
Dopamine bindingdefinition[GO:0035240]  
1
  • IDABHF-UCL
Dopamine neurotransmitter receptor activitydefinition[GO:0004952]  
1
  • IDABHF-UCL
Dopamine neurotransmitter receptor activity, coupled via Gi/Godefinition[GO:0001591]  
1
  • IDABHF-UCL
  • ISSOrtholog Curator
Drug bindingdefinition[GO:0008144]  
3
  • IDABHF-UCL
Identical protein bindingdefinition[GO:0042802]  
1
  • IPIIntAct
Potassium channel regulator activitydefinition[GO:0015459]  
1
  • NASBHF-UCL
Protein bindingdefinition[GO:0005515]  
1
  • IPIBHF-UCL
SH3 domain bindingdefinition[GO:0017124]  
1
  • IDABHF-UCL
GO biological process 
Activation of MAPK activitydefinition[GO:0000187]  
2
  • IDABHF-UCL
Adenylate cyclase-inhibiting dopamine receptor signaling pathwaydefinition[GO:0007195]  
1
  • IDABHF-UCL
Adult locomotory behaviordefinition[GO:0008344]  
  • ISSOrtholog Curator
Arachidonic acid secretiondefinition[GO:0050482]  
1
  • IDABHF-UCL
Behavioral fear responsedefinition[GO:0001662]  
1
  • NASBHF-UCL
Behavioral response to cocainedefinition[GO:0048148]  
  • ISSOrtholog Curator
Behavioral response to ethanoldefinition[GO:0048149]  
1
  • TASBHF-UCL
Cellular calcium ion homeostasisdefinition[GO:0006874]  
1
  • ICBHF-UCL
Circadian rhythmdefinition[GO:0007623] silver  
  • IEAOrtholog Compara
Dopamine metabolic processdefinition[GO:0042417]  
1
  • ICBHF-UCL
Dopamine receptor signaling pathwaydefinition[GO:0007212]  
1
  • IDABHF-UCL
Fear responsedefinition[GO:0042596]  
  • ISSOrtholog Curator
Negative regulation of adenylate cyclase activitydefinition[GO:0007194]  
1
  • IDABHF-UCL
Negative regulation of cAMP biosynthetic processdefinition[GO:0030818]  
2
  • IDABHF-UCL
Negative regulation of protein secretiondefinition[GO:0050709]  
1
  • IDABHF-UCL
Negative regulation of voltage-gated calcium channel activitydefinition[GO:1901386]  
1
  • IDABHF-UCL
Olfactory learningdefinition[GO:0008355] silver  
  • IEAOrtholog Compara
Photoperiodismdefinition[GO:0009648] silver  
  • IEAOrtholog Compara
Positive regulation of dopamine uptake involved in synaptic transmissiondefinition[GO:0051586]  
1
  • ICBHF-UCL
Positive regulation of excitatory postsynaptic membrane potentialdefinition[GO:2000463] silver  
  • IEAOrtholog Compara
Positive regulation of kinase activitydefinition[GO:0033674]  
1
  • IDABHF-UCL
Positive regulation of penile erectiondefinition[GO:0060406] silver  
  • IEAOrtholog Compara
Positive regulation of sodium:hydrogen antiporter activitydefinition[GO:0032417]  
1
  • IDABHF-UCL
Regulation of calcium-mediated signalingdefinition[GO:0050848] silver  
  • IEAOrtholog Compara
Regulation of circadian rhythmdefinition[GO:0042752]  
  • ISSOrtholog Curator
Regulation of dopamine metabolic processdefinition[GO:0042053]  
  • ISSOrtholog Curator
Regulation of inhibitory postsynaptic membrane potentialdefinition[GO:0060080]  
  • ISSOrtholog Curator
Regulation of neurotransmitter secretiondefinition[GO:0046928] silver  
  • IEAOrtholog Compara
Response to amphetaminedefinition[GO:0001975]  
  • ISSOrtholog Curator
Response to histaminedefinition[GO:0034776]  
1
  • IDABHF-UCL
Response to steroid hormonedefinition[GO:0048545] silver  
  • IEAOrtholog Compara
Retina development in camera-type eyedefinition[GO:0060041] silver  
  • IEAOrtholog Compara
Short-term memorydefinition[GO:0007614] silver  
  • IEAOrtholog Compara
Social behaviordefinition[GO:0035176]  
2
  • NASBHF-UCL
Synaptic transmission, dopaminergicdefinition[GO:0001963] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Dopaminergic synapse  hsa04728+1815  
Neuroactive ligand-receptor interaction  hsa04080+1815  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Dopamine_receptor_D4
GenomeRNAi: 1815
PRO: PR:P21917
Chemistry
GuidetoPHARMACOLOGY: 217