DRD5 - D(1B) dopamine receptor - human protein (Function)
 
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DRD5 »  D(1B) dopamine receptor
 
Protein also known as:  D1beta dopamine receptor.
Gene name:  DRD5
Entry whose protein(s) existence is based on evidence at protein level
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1 65 1
GENE REF ISO

Function

 show evidences
Overview 
Dopamine receptor whose activity is mediated by G proteins which activate adenylyl cyclase.  
1
  • CuratedUniProtKB
GO molecular function 
Dopamine bindingdefinition[GO:0035240]  
1
  • IDAUniProtKB
Dopamine neurotransmitter receptor activitydefinition[GO:0004952]  
1
  • IDAUniProtKB
Dopamine neurotransmitter receptor activity, coupled via Gsdefinition[GO:0001588]  
1
  • TASBHF-UCL
GO biological process 
Activation of adenylate cyclase activitydefinition[GO:0007190]  
1
  • TASBHF-UCL
Adenylate cyclase-activating dopamine receptor signaling pathwaydefinition[GO:0007191]  
2
  • IDABHF-UCL
  • IDAUniProtKB
Adenylate cyclase-activating G-protein coupled receptor signaling pathwaydefinition[GO:0007189]  
1
  • IDAUniProtKB
Associative learningdefinition[GO:0008306] silver  
  • IEAOrtholog Compara
Cellular calcium ion homeostasisdefinition[GO:0006874]  
1
  • TASBHF-UCL
Cellular response to catecholamine stimulusdefinition[GO:0071870]  
1
  • IDABHF-UCL
Long term synaptic depressiondefinition[GO:0060292] silver  
  • IEAOrtholog Compara
Negative regulation of blood pressuredefinition[GO:0045776] silver  
  • IEAOrtholog Compara
Negative regulation of NAD(P)H oxidase activitydefinition[GO:0033861]  
1
  • IDAUniProtKB
Norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressuredefinition[GO:0001994] silver  
  • IEAOrtholog Compara
Phospholipase C-activating dopamine receptor signaling pathwaydefinition[GO:0060158]  
1
  • TASBHF-UCL
Positive regulation of adenylate cyclase activitydefinition[GO:0045762]  
2
  • NASUniProtKB
Positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwaydefinition[GO:0010579] silver  
  • IEAInterPro 2 GO
Reactive oxygen species metabolic processdefinition[GO:0072593]  
1
  • IDAUniProtKB
Regulation of female receptivitydefinition[GO:0045924] silver  
  • IEAOrtholog Compara
Regulation of systemic arterial blood pressure by vasopressindefinition[GO:0001992] silver  
  • IEAOrtholog Compara
Response to amphetaminedefinition[GO:0001975] silver  
  • IEAOrtholog Compara
Response to cocainedefinition[GO:0042220] silver  
  • IEAOrtholog Compara
Sensitizationdefinition[GO:0046960] silver  
  • IEAOrtholog Compara
Synaptic transmissiondefinition[GO:0007268]  
1
  • NASUniProtKB
Synaptic transmission, dopaminergicdefinition[GO:0001963]  
1
  • NASUniProtKB
Wound healingdefinition[GO:0042060] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+1816  
Dopaminergic synapse  hsa04728+1816  
Neuroactive ligand-receptor interaction  hsa04080+1816  
According to Reactome, this protein belongs to the following pathway:
Signal Transduction  REACT_111102  
 

Keywords

Molecular function 
G-protein coupled receptor  definition   [KW-0297]
Receptor  definition   [KW-0675]
Transducer  definition   [KW-0807]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Dopamine_receptor_D5
GenomeRNAi: 1816
PRO: PR:P21918
Chemistry
GuidetoPHARMACOLOGY: 218