BMP5 - Bone morphogenetic protein 5 - human protein (Function)
 
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BMP5 »  Bone morphogenetic protein 5  (BMP-5)
 
Gene name:  BMP5
Family name: TGF-beta
Entry whose protein(s) existence is based on evidence at transcript level
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1 34 1
GENE REF ISO

Function

 show evidences
Overview 
Induces cartilage and bone formation.  
  • CuratedUniProtKB
GO molecular function 
BMP receptor bindingdefinition[GO:0070700]  
1
  • IPIMGI
Cytokine activitydefinition[GO:0005125]  
  • IEAUniProtKB KW
Growth factor activitydefinition[GO:0008083]  
  • IEAUniProtKB KW
GO biological process 
Cartilage developmentdefinition[GO:0051216]  
  • IEAUniProtKB KW
Growthdefinition[GO:0040007] silver  
  • IEAInterPro 2 GO
Male genitalia developmentdefinition[GO:0030539] silver  
  • IEAOrtholog Compara
Negative regulation of aldosterone biosynthetic processdefinition[GO:0032348]  
1
  • IDABHF-UCL
Negative regulation of cell proliferationdefinition[GO:0008285]  
1
  • IDABHF-UCL
Negative regulation of cortisol biosynthetic processdefinition[GO:2000065]  
1
  • IDABHF-UCL
Negative regulation of epithelial to mesenchymal transitiondefinition[GO:0010719]  
1
  • NASBHF-UCL
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsdefinition[GO:1902042]  
1
  • NASBHF-UCL
Negative regulation of insulin-like growth factor receptor signaling pathwaydefinition[GO:0043569]  
1
  • IDABHF-UCL
Negative regulation of mononuclear cell migrationdefinition[GO:0071676]  
1
  • NASBHF-UCL
Negative regulation of steroid biosynthetic processdefinition[GO:0010894]  
1
  • IDABHF-UCL
Ossificationdefinition[GO:0001503]  
  • IEAUniProtKB KW
Pattern specification processdefinition[GO:0007389] silver  
  • IEAOrtholog Compara
Positive regulation of dendrite developmentdefinition[GO:1900006]  
1
  • IDABHF-UCL
Positive regulation of DNA-dependent DNA replicationdefinition[GO:2000105]  
1
  • IDABHF-UCL
Positive regulation of epithelial cell proliferationdefinition[GO:0050679]  
1
  • IDABHF-UCL
Positive regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0010862]  
1
  • IDABHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
1
  • IDABHF-UCL
Skeletal system developmentdefinition[GO:0001501]  
1
  • NASUniProtKB
Type B pancreatic cell developmentdefinition[GO:0003323]  
1
  • IDABHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Hedgehog signaling pathway  hsa04340+653  
TGF-beta signaling pathway  hsa04350+653  
 

Keywords

Biological process 
Chondrogenesis  definition   [KW-0891]
Differentiation  definition   [KW-0221]
Osteogenesis  definition   [KW-0892]
Molecular function 
Cytokine  definition   [KW-0202]
Developmental protein  definition   [KW-0217]
Growth factor  definition   [KW-0339]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links