BMP6 - Bone morphogenetic protein 6 - human protein (Function)
 
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BMP6 »  Bone morphogenetic protein 6  (BMP-6)
 
Protein also known as:  VG-1-related protein (VGR-1).
Gene name:  BMP6
Family name: TGF-beta
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 84 1
GENE REF ISO

Function

 show evidences
Overview 
Induces cartilage and bone formation.  
  • CuratedUniProtKB
GO molecular function 
BMP receptor bindingdefinition[GO:0070700]  
1
  • IPIMGI
Cytokine activitydefinition[GO:0005125]  
  • IEAUniProtKB KW
Growth factor activitydefinition[GO:0008083] silver  
  • IEAOrtholog Compara
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IDAMGI
GO biological process 
BMP signaling pathwaydefinition[GO:0030509]  
1
  • IDABHF-UCL
Cartilage developmentdefinition[GO:0051216]  
  • IEAUniProtKB KW
Cellular response to mechanical stimulusdefinition[GO:0071260] silver  
  • IEAOrtholog Compara
Endochondral ossificationdefinition[GO:0001958] silver  
  • IEAOrtholog Compara
Eye developmentdefinition[GO:0001654] silver  
  • IEAOrtholog Compara
Growthdefinition[GO:0040007] silver  
  • IEAInterPro 2 GO
Immune responsedefinition[GO:0006955]  
1
  • IMPBHF-UCL
Inflammatory responsedefinition[GO:0006954] silver  
  • IEAOrtholog Compara
Kidney developmentdefinition[GO:0001822] silver  
  • IEAOrtholog Compara
Male genitalia developmentdefinition[GO:0030539] silver  
  • IEAOrtholog Compara
Osteoblast differentiationdefinition[GO:0001649] silver  
  • IEAOrtholog Compara
Positive regulation of aldosterone biosynthetic processdefinition[GO:0032349]  
1
  • IDAUniProtKB
Positive regulation of aldosterone secretiondefinition[GO:2000860] silver  
  • IEAOrtholog Compara
Positive regulation of bone mineralizationdefinition[GO:0030501]  
1
  • IDABHF-UCL
Positive regulation of chondrocyte differentiationdefinition[GO:0032332] silver  
  • IEAOrtholog Compara
Positive regulation of DNA-dependent DNA replicationdefinition[GO:2000105]  
1
  • NASBHF-UCL
Positive regulation of endothelial cell differentiationdefinition[GO:0045603] silver  
  • IEAOrtholog Compara
Positive regulation of endothelial cell proliferationdefinition[GO:0001938] silver  
  • IEAOrtholog Compara
Positive regulation of epithelial cell proliferationdefinition[GO:0050679]  
1
  • IDABHF-UCL
Positive regulation of neuron differentiationdefinition[GO:0045666] silver  
  • IEAOrtholog Compara
Positive regulation of osteoblast differentiationdefinition[GO:0045669]  
1
  • IDABHF-UCL
Positive regulation of pathway-restricted SMAD protein phosphorylationdefinition[GO:0010862]  
2
  • IDABHF-UCL
  • IDAUniProtKB
Positive regulation of protein secretiondefinition[GO:0050714]  
1
  • NASBHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944]  
2
  • IDAUniProtKB
  • NASBHF-UCL
Response to activitydefinition[GO:0014823] silver  
  • IEAOrtholog Compara
Response to glucocorticoiddefinition[GO:0051384] silver  
  • IEAOrtholog Compara
Response to iron iondefinition[GO:0010039] silver  
  • IEAOrtholog Compara
Response to magnesium iondefinition[GO:0032026] silver  
  • IEAOrtholog Compara
Response to retinoic aciddefinition[GO:0032526] silver  
  • IEAOrtholog Compara
Skeletal system developmentdefinition[GO:0001501]  
1
  • TASPINC
SMAD protein signal transductiondefinition[GO:0060395]  
1
  • IDAUniProtKB
Type B pancreatic cell developmentdefinition[GO:0003323]  
1
  • IDABHF-UCL
Pathways 
According to KEGG, this protein belongs to the following pathways:
Hedgehog signaling pathway  hsa04340+654  
TGF-beta signaling pathway  hsa04350+654  
 

Keywords

Biological process 
Chondrogenesis  definition   [KW-0891]
Differentiation  definition   [KW-0221]
Osteogenesis  definition   [KW-0892]
Molecular function 
Cytokine  definition   [KW-0202]
Developmental protein  definition   [KW-0217]
Growth factor  definition   [KW-0339]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links