GART - Trifunctional purine biosynthetic protein adenosine-3 - human protein (Function)
 
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GART »  Trifunctional purine biosynthetic protein adenosine-3
 
Gene name:  GART
Family names: In the central section AIR synthase
In the N-terminal section GARS
In the C-terminal section GART
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Methyltransferase activitydefinition[GO:0008168] silver  
  • IEAInterPro 2 GO
Phosphoribosylamine-glycine ligase activitydefinition[GO:0004637]  
  • IEAEC 2 GO
Phosphoribosylformylglycinamidine cyclo-ligase activitydefinition[GO:0004641]  
  • IEAEC 2 GO
Phosphoribosylglycinamide formyltransferase activitydefinition[GO:0004644]  
  • IEAEC 2 GO
GO biological process 
'de novo' IMP biosynthetic processdefinition[GO:0006189]  
  • IEAUniPathway
Brainstem developmentdefinition[GO:0003360] silver  
  • IEAOrtholog Compara
Cerebellum developmentdefinition[GO:0021549] silver  
  • IEAOrtholog Compara
Cerebral cortex developmentdefinition[GO:0021987] silver  
  • IEAOrtholog Compara
Glycine metabolic processdefinition[GO:0006544] silver  
  • IEAOrtholog Compara
Purine nucleobase biosynthetic processdefinition[GO:0009113] silver  
  • IEAInterPro 2 GO
Response to inorganic substancedefinition[GO:0010035] silver  
  • IEAOrtholog Compara
Response to organic substancedefinition[GO:0010033] silver  
  • IEAOrtholog Compara
Tetrahydrofolate biosynthetic processdefinition[GO:0046654] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
EC 6.3.4.13: ATP + 5-phospho-D-ribosylamine + glycine ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide.  
  • CuratedUniProtKB
EC 6.3.3.1: ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.  
  • CuratedUniProtKB
EC 2.1.2.2: 10-formyltetrahydrofolate + N(1)-(5-phospho-D-ribosyl)glycinamide tetrahydrofolate + N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathways
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+2618  
One carbon pool by folate  hsa00670+2618  
Purine metabolism  hsa00230+2618  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 
More information is available from:
 

Keywords

Biological process 
Purine biosynthesis  definition   [KW-0658]
Molecular function 
Ligase  definition   [KW-0436]
Transferase  definition   [KW-0808]
Technical term 
Multifunctional enzyme  definition   [KW-0511]
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 2618
PRO: PR:P22102