IL10 - Interleukin-10 - human protein (Function)
 
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IL10 »  Interleukin-10  (IL-10)
 
Protein also known as:  Cytokine synthesis inhibitory factor (CSIF).
Gene name:  IL10
Family name: IL-10
Entry whose protein(s) existence is based on evidence at protein level
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1 1012 1
GENE REF ISO

Function

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Overview 
Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells.  
  • CuratedUniProtKB
GO molecular function 
Cytokine activitydefinition[GO:0005125]  
1
  • NASBHF-UCL
Growth factor activitydefinition[GO:0008083]  
1
  • NASUniProtKB
Interleukin-10 receptor bindingdefinition[GO:0005141]  
1
  • NASUniProtKB
GO biological process 
B cell differentiationdefinition[GO:0030183]  
1
  • NASUniProtKB
B cell proliferationdefinition[GO:0042100]  
1
  • NASUniProtKB
Branching involved in labyrinthine layer morphogenesisdefinition[GO:0060670] silver  
  • IEAOrtholog Compara
Cell-cell signalingdefinition[GO:0007267]  
1
  • ICUniProtKB
Cellular response to estradiol stimulusdefinition[GO:0071392] silver  
  • IEAOrtholog Compara
Cellular response to lipopolysaccharidedefinition[GO:0071222]  
1
  • NASBHF-UCL
Cytoplasmic sequestering of NF-kappaBdefinition[GO:0007253]  
1
  • NASUniProtKB
Defense response to bacteriumdefinition[GO:0042742] silver  
  • IEAOrtholog Compara
Hemopoiesisdefinition[GO:0030097]  
1
  • TASUniProtKB
Inflammatory responsedefinition[GO:0006954]  
1
  • IDABHF-UCL
Leukocyte chemotaxisdefinition[GO:0030595]  
1
  • TASPINC
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • NASUniProtKB
Negative regulation of B cell proliferationdefinition[GO:0030889]  
1
  • IDAMGI
Negative regulation of chronic inflammatory response to antigenic stimulusdefinition[GO:0002875] silver  
  • IEAOrtholog Compara
Negative regulation of cytokine secretion involved in immune responsedefinition[GO:0002740]  
1
  • IDABHF-UCL
Negative regulation of growth of symbiont in hostdefinition[GO:0044130] silver  
  • IEAOrtholog Compara
Negative regulation of interferon-alpha biosynthetic processdefinition[GO:0045355]  
1
  • NASUniProtKB
Negative regulation of interferon-gamma productiondefinition[GO:0032689] silver  
  • IEAOrtholog Compara
Negative regulation of interleukin-12 productiondefinition[GO:0032695] silver  
  • IEAOrtholog Compara
Negative regulation of interleukin-6 productiondefinition[GO:0032715]  
1
  • IDABHF-UCL
Negative regulation of membrane protein ectodomain proteolysisdefinition[GO:0051045]  
1
  • IDABHF-UCL
Negative regulation of MHC class II biosynthetic processdefinition[GO:0045347]  
1
  • TASUniProtKB
Negative regulation of myeloid dendritic cell activationdefinition[GO:0030886] silver  
  • IEAOrtholog Compara
Negative regulation of nitric oxide biosynthetic processdefinition[GO:0045019] silver  
  • IEAOrtholog Compara
Negative regulation of T cell proliferationdefinition[GO:0042130]  
2
  • NASBHF-UCL
  • NASUniProtKB
Negative regulation of tumor necrosis factor biosynthetic processdefinition[GO:0042536] silver  
  • IEAOrtholog Compara
Negative regulation of tumor necrosis factor productiondefinition[GO:0032720] silver  
  • IEAOrtholog Compara
Positive regulation of B cell apoptotic processdefinition[GO:0002904]  
1
  • IDAMGI
Positive regulation of cytokine secretiondefinition[GO:0050715]  
1
  • IDABHF-UCL
Positive regulation of MHC class II biosynthetic processdefinition[GO:0045348] silver  
  • IEAOrtholog Compara
Positive regulation of sequence-specific DNA binding transcription factor activitydefinition[GO:0051091]  
1
  • IDABHF-UCL
Positive regulation of transcription from RNA polymerase II promoterdefinition[GO:0045944] silver  
  • IEAOrtholog Compara
Positive regulation of transcription, DNA-templateddefinition[GO:0045893]  
1
  • IDABHF-UCL
Receptor biosynthetic processdefinition[GO:0032800]  
1
  • IDABHF-UCL
Regulation of gene expressiondefinition[GO:0010468]  
1
  • IDAMGI
Regulation of isotype switchingdefinition[GO:0045191]  
1
  • NASUniProtKB
Regulation of sensory perception of paindefinition[GO:0051930] silver  
  • IEAOrtholog Compara
Response to activitydefinition[GO:0014823] silver  
  • IEAOrtholog Compara
Response to carbon monoxidedefinition[GO:0034465] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to glucocorticoiddefinition[GO:0051384]  
1
  • IDABHF-UCL
Response to inactivitydefinition[GO:0014854] silver  
  • IEAOrtholog Compara
Response to insulindefinition[GO:0032868] silver  
  • IEAOrtholog Compara
Response to molecule of bacterial origindefinition[GO:0002237]  
1
  • IDAUniProtKB
Type 2 immune responsedefinition[GO:0042092]  
1
  • TASUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
African trypanosomiasis  hsa05143+3586  
Allograft rejection  hsa05330+3586  
Amoebiasis  hsa05146+3586  
Asthma  hsa05310+3586  
Autoimmune thyroid disease  hsa05320+3586  
Chagas disease (American trypanosomiasis)  hsa05142+3586  
Cytokine-cytokine receptor interaction  hsa04060+3586  
Intestinal immune network for IgA production  hsa04672+3586  
Jak-STAT signaling pathway  hsa04630+3586  
Leishmaniasis  hsa05140+3586  
Malaria  hsa05144+3586  
Pertussis  hsa05133+3586  
Staphylococcus aureus infection  hsa05150+3586  
Systemic lupus erythematosus  hsa05322+3586  
T cell receptor signaling pathway  hsa04660+3586  
Toxoplasmosis  hsa05145+3586  
Tuberculosis  hsa05152+3586  
 

Keywords

Molecular function 
Cytokine  definition   [KW-0202]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Interleukin_10
GenomeRNAi: 3586
PRO: PR:P22301