ACHE - Acetylcholinesterase - human protein (Function)
 
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ACHE »  Acetylcholinesterase   [ EC 3.1.1.7 ]  (AChE)
 
Gene name:  ACHE
Entry whose protein(s) existence is based on evidence at protein level
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1 130 4
GENE REF ISO

Function

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Overview 
Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.  
4
  • CuratedUniProtKB
GO molecular function 
Acetylcholine bindingdefinition[GO:0042166]  
2
  • IDAHGNC
  • NASUniProtKB
Acetylcholinesterase activitydefinition[GO:0003990]  
2
  • IMPUniProtKB
  • IDAHGNC
Beta-amyloid bindingdefinition[GO:0001540]  
1
  • TASUniProtKB
Cholinesterase activitydefinition[GO:0004104]  
1
  • IDAHGNC
Collagen bindingdefinition[GO:0005518]  
1
  • IDAHGNC
Hydrolase activitydefinition[GO:0016787]  
1
  • IDAHGNC
Laminin bindingdefinition[GO:0043236]  
1
  • IDABHF-UCL
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
2
  • IPIHGNC
  • NASUniProtKB
Protein self-associationdefinition[GO:0043621] silver  
  • IEAOrtholog Compara
Serine hydrolase activitydefinition[GO:0017171]  
1
  • IDAHGNC
GO biological process 
Acetylcholine catabolic processdefinition[GO:0006581]  
1
  • IDAHGNC
Acetylcholine catabolic process in synaptic cleftdefinition[GO:0001507]  
1
  • NASUniProtKB
Amyloid precursor protein metabolic processdefinition[GO:0042982]  
1
  • TASUniProtKB
Cell adhesiondefinition[GO:0007155]  
2
  • IDAHGNC
  • TASUniProtKB
Cell proliferationdefinition[GO:0008283]  
1
  • TASUniProtKB
Choline metabolic processdefinition[GO:0019695] silver  
  • IBARefGenome
DNA replicationdefinition[GO:0006260]  
1
  • TASUniProtKB
Muscle organ developmentdefinition[GO:0007517]  
1
  • TASUniProtKB
Negative regulation of synaptic transmission, cholinergicdefinition[GO:0032223]  
1
  • ICHGNC
Nervous system developmentdefinition[GO:0007399]  
1
  • TASUniProtKB
Neurotransmitter receptor biosynthetic processdefinition[GO:0045212] silver  
  • IEAOrtholog Compara
Osteoblast developmentdefinition[GO:0002076]  
1
  • IEPHGNC
Positive regulation of protein secretiondefinition[GO:0050714]  
1
  • TASUniProtKB
Protein tetramerizationdefinition[GO:0051262] silver  
  • IEAOrtholog Compara
Receptor internalizationdefinition[GO:0031623] silver  
  • IEAOrtholog Compara
Regulation of axonogenesisdefinition[GO:0050770] silver  
  • IBARefGenome
Regulation of dendrite morphogenesisdefinition[GO:0048814] silver  
  • IBARefGenome
Regulation of receptor recyclingdefinition[GO:0001919] silver  
  • IEAOrtholog Compara
Response to woundingdefinition[GO:0009611]  
1
  • TASUniProtKB
Retina development in camera-type eyedefinition[GO:0060041] silver  
  • IEAOrtholog Compara
Synapse assemblydefinition[GO:0007416]  
1
  • TASUniProtKB
  • IBARefGenome
Synaptic transmission, cholinergicdefinition[GO:0007271] silver  
  • IBARefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.1.7: Acetylcholine + H(2)O choline + acetate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Cholinergic synapse  hsa04725+43  
Glycerophospholipid metabolism  hsa00564+43  
According to Reactome, this protein belongs to the following pathways:
Metabolism  REACT_111217  
Metabolism of proteins  REACT_17015  
Neuronal System  REACT_13685  
 

Keywords

Biological process 
Neurotransmitter degradation  definition   [KW-0531]
Molecular function 
Blood group antigen  definition   [KW-0095]
Hydrolase  definition   [KW-0378]
Serine esterase  definition   [KW-0719]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P22303
Other
GeneWiki: Acetylcholinesterase
GenomeRNAi: 43
PRO: PR:P22303
Chemistry
GuidetoPHARMACOLOGY: 2465