IDS - Iduronate 2-sulfatase - human protein (Function)
 
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IDS »  Iduronate 2-sulfatase
 
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    Protein also known as:  Alpha-L-iduronate sulfate sulfatase (Idursulfase). Cleaved into:  Iduronate 2-sulfatase 14 kDa chain; Iduronate 2-sulfatase 42 kDa chain.
    Gene name:  IDS
    Family name: Sulfatase
    One or more isoforms of this protein have been shown to exist at protein level
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    Function

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    Overview 
    Required for the lysosomal degradation of heparan sulfate and dermatan sulfate.  
    • CuratedUniProtKB
    GO molecular function 
    Metal ion bindingdefinition[GO:0046872]  
    • IEAUniProtKB KW
    Enzymatic activity 
    This protein acts as an enzyme. It is known to catalyze the following reaction
    EC 3.1.6.13: Hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin.  
    • CuratedUniProtKB
    It requires the following cofactor
    Binds 1 calcium ion per subunit (By similarity).  
    • CuratedUniProtKB
    Pathways 
    According to KEGG, this protein belongs to the following pathways:
    Glycosaminoglycan degradation  hsa00531+3423  
    Lysosome  hsa04142+3423  
    Metabolic pathways  hsa01100+3423  
    According to Reactome, this protein belongs to the following pathways:
    Disease  REACT_116125  
    Metabolism  REACT_111217  
     
    More information is available from:
     

    Keywords

    Molecular function 
    Hydrolase  definition   [KW-0378]
    Technical term 
    Reference proteome  definition   [KW-1185]
     

    neXtProt

    SIB  Genebio