UGT1A1 - UDP-glucuronosyltransferase 1-1 - human protein (Function)
 
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UGT1A1 »  UDP-glucuronosyltransferase 1-1   [ EC 2.4.1.17 ]  (UGT1.1)
 
Protein also known as:  Bilirubin-specific UDPGT isozyme 1.
Gene name:  UGT1A1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 268 1
GENE REF ISO

Function

 show evidences
Overview 
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone.  
2
  • CuratedUniProtKB
GO molecular function 
Enzyme bindingdefinition[GO:0019899]  
1
  • IDABHF-UCL
Enzyme inhibitor activitydefinition[GO:0004857]  
1
  • IDABHF-UCL
Glucuronosyltransferase activitydefinition[GO:0015020]  
4
  • IDABHF-UCL
Protein heterodimerization activitydefinition[GO:0046982]  
1
  • IPIBHF-UCL
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIBHF-UCL
Retinoic acid bindingdefinition[GO:0001972]  
1
  • IDABHF-UCL
Steroid bindingdefinition[GO:0005496]  
1
  • IDABHF-UCL
GO biological process 
Acute-phase responsedefinition[GO:0006953] silver  
  • IEAOrtholog Compara
Bilirubin conjugationdefinition[GO:0006789]  
1
  • TASPINC
Biphenyl catabolic processdefinition[GO:0070980] silver  
  • IEAOrtholog Compara
Cellular response to ethanoldefinition[GO:0071361] silver  
  • IEAOrtholog Compara
Cellular response to glucocorticoid stimulusdefinition[GO:0071385] silver  
  • IEAOrtholog Compara
Digestiondefinition[GO:0007586]  
1
  • NASPINC
Drug metabolic processdefinition[GO:0017144]  
1
  • ICBHF-UCL
Estrogen metabolic processdefinition[GO:0008210]  
1
  • TASPINC
Flavone metabolic processdefinition[GO:0051552]  
1
  • IDABHF-UCL
Flavonoid glucuronidationdefinition[GO:0052696]  
1
  • IDABHF-UCL
Heterocycle metabolic processdefinition[GO:0046483]  
1
  • ICBHF-UCL
Liver developmentdefinition[GO:0001889] silver  
  • IEAOrtholog Compara
Negative regulation of catalytic activitydefinition[GO:0043086]  
1
  • IDAGOC
Negative regulation of steroid metabolic processdefinition[GO:0045939]  
1
  • ICBHF-UCL
Organ regenerationdefinition[GO:0031100] silver  
  • IEAOrtholog Compara
Regulation of catalytic activitydefinition[GO:0050790]  
1
  • IDAGOC
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to lipopolysaccharidedefinition[GO:0032496] silver  
  • IEAOrtholog Compara
Response to nutrientdefinition[GO:0007584] silver  
  • IEAOrtholog Compara
Response to starvationdefinition[GO:0042594] silver  
  • IEAOrtholog Compara
Retinoic acid metabolic processdefinition[GO:0042573]  
1
  • ICBHF-UCL
Steroid metabolic processdefinition[GO:0008202]  
1
  • ICBHF-UCL
Xenobiotic glucuronidationdefinition[GO:0052697]  
1
  • IDABHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.4.1.17: UDP-glucuronate + acceptor UDP + acceptor beta-D-glucuronoside.  
1
  • CuratedUniProtKB
According to CAZy, this protein is belongs to the following pathway:
Glycosyltransferase Family 1  GT1  
Pathways 
According to KEGG, this protein belongs to the following pathways:
Ascorbate and aldarate metabolism  hsa00053+54658  
Drug metabolism - cytochrome P450  hsa00982+54658  
Drug metabolism - other enzymes  hsa00983+54658  
Metabolic pathways  hsa01100+54658  
Metabolism of xenobiotics by cytochrome P450  hsa00980+54658  
Other types of O-glycan biosynthesis  hsa00514+54658  
Pentose and glucuronate interconversions  hsa00040+54658  
Porphyrin and chlorophyll metabolism  hsa00860+54658  
Retinol metabolism  hsa00830+54658  
Starch and sucrose metabolism  hsa00500+54658  
Steroid hormone biosynthesis  hsa00140+54658  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Biophysicochemical properties

Kinetic parameters
KM 0.26 uM for bilirubin
Vmax 1080 pmol/min/mg enzyme with bilirubin as substrate

Keywords

Molecular function 
Glycosyltransferase  definition   [KW-0328]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P22309
Other
GenomeRNAi: 54658
PRO: PR:P22309