KCNA4 - Potassium voltage-gated channel subfamily A member 4 - human protein (Function)
 
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KCNA4 »  Potassium voltage-gated channel subfamily A member 4
 
Protein also known as:  Voltage-gated potassium channel subunit Kv1.4.
Gene name:  KCNA4
Entry whose protein(s) existence is based on evidence at protein level
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1 41 1
GENE REF ISO

Function

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Overview 
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed19912772, PubMed8495559). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed8495559). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Homotetrameric KCNA4 forms a potassium channel that opens in response to membrane depolarization, followed by rapid spontaneous channel closure (PubMed19912772, PubMed8495559). Likewise, a heterotetrameric channel formed by KCNA1 and KCNA4 shows rapid inactivation (PubMed17156368).  
4
  • UniProtKB
GO molecular function 
Not  Delayed rectifier potassium channel activitydefinition[GO:0005251]  
1
  • RefGenome
Potassium ion bindingdefinition[GO:0030955] silver  
1
  • InterPro 2 GO
Protein bindingdefinition[GO:0005515]  
4
  • UniProtKB
  • IntAct
Voltage-gated potassium channel activitydefinition[GO:0005249]  
2
  • UniProtKB
GO biological process 
Potassium ion transmembrane transportdefinition[GO:0071805]  
3
  • UniProtKB
  • RefGenome
Potassium ion transportdefinition[GO:0006813]  
1
  • PINC
Protein homooligomerizationdefinition[GO:0051260] silver  
1
  • InterPro 2 GO
Regulation of ion transmembrane transportdefinition[GO:0034765]  
1
  • UniProtKB KW
Enzymatic activity 
It is regulated in the following manner
Inhibited by 4-aminopyridine (4-AP), but not by tetraethylammonium (TEA) and charybdotoxin (CTX).  
2
  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Voltage gated Potassium channels  REACT_75770  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Potassium channel  definition   [KW-0631]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: KCNA4
GenomeRNAi: 3739
PRO: PR:P22459