KCNA5 - Potassium voltage-gated channel subfamily A member 5 - human protein (Function)
 
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Gene
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KCNA5 »  Potassium voltage-gated channel subfamily A member 5
 
Protein also known as:  Voltage-gated potassium channel subunit Kv1.5.
Gene name:  KCNA5
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 96 2
GENE REF ISO

Function

 show evidences
Overview 
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA5, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed12130714). Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation (PubMed12130714). Homotetrameric channels display rapid activation and slow inactivation (PubMed8505626, PubMed12130714). May play a role in regulating the secretion of insulin in normal pancreatic islets.  
3
  • UniProtKB
Isoform  Iso 2   Exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation (PubMed11524461).  
4
  • UniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.2.4  
GO molecular function 
Alpha-actinin bindingdefinition[GO:0051393]  
1
  • BHF-UCL
Delayed rectifier potassium channel activitydefinition[GO:0005251]  
3
  • BHF-UCL
  • UniProtKB
Outward rectifier potassium channel activitydefinition[GO:0015271]  
2
  • BHF-UCL
Potassium channel inhibitor activitydefinition[GO:0019870] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
2
  • IntAct
Protein kinase bindingdefinition[GO:0019901]  
1
  • BHF-UCL
Receptor bindingdefinition[GO:0005102] silver  
1
  • Ortholog Compara
Scaffold protein bindingdefinition[GO:0097110]  
2
  • BHF-UCL
Voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarizationdefinition[GO:0086089]  
2
  • BHF-UCL
Voltage-gated potassium channel activity involved in bundle of His cell action potential repolarizationdefinition[GO:0086087]  
1
  • BHF-UCL
Voltage-gated potassium channel activity involved in SA node cell action potential repolarizationdefinition[GO:0086090]  
1
  • BHF-UCL
GO biological process 
Atrial cardiac muscle cell action potentialdefinition[GO:0086014]  
2
  • BHF-UCL
Membrane hyperpolarizationdefinition[GO:0060081]  
1
  • BHF-UCL
Membrane repolarization during bundle of His cell action potentialdefinition[GO:0086050]  
1
  • BHF-UCL
Membrane repolarization during SA node cell action potentialdefinition[GO:0086052]  
1
  • BHF-UCL
Negative regulation of cytosolic calcium ion concentrationdefinition[GO:0051481] silver  
1
  • Ortholog Compara
Negative regulation of potassium ion transportdefinition[GO:0043267] silver  
1
  • Ortholog Compara
Positive regulation of G1/S transition of mitotic cell cycledefinition[GO:1900087] silver  
1
  • Ortholog Compara
Positive regulation of myoblast proliferationdefinition[GO:2000288] silver  
1
  • Ortholog Compara
Potassium ion exportdefinition[GO:0071435]  
3
  • BHF-UCL
Potassium ion homeostasisdefinition[GO:0055075] silver  
1
  • Ortholog Compara
Potassium ion transmembrane transportdefinition[GO:0071805]  
1
  • UniProtKB
Potassium ion transportdefinition[GO:0006813]  
1
  • MGI
Protein homooligomerizationdefinition[GO:0051260] silver  
1
  • InterPro 2 GO
Regulation of atrial cardiac muscle cell membrane repolarizationdefinition[GO:0060372]  
1
  • BHF-UCL
Regulation of heart rate by cardiac conductiondefinition[GO:0086091]  
2
  • BHF-UCL
Regulation of insulin secretiondefinition[GO:0050796]  
1
  • BHF-UCL
Regulation of membrane potentialdefinition[GO:0042391]  
1
  • BHF-UCL
Regulation of potassium ion transportdefinition[GO:0043266]  
1
  • BHF-UCL
Regulation of vasoconstrictiondefinition[GO:0019229] silver  
1
  • Ortholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
1
  • Ortholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
Voltage gated Potassium channels  REACT_75770  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Potassium channel  definition   [KW-0631]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNA5
GenomeRNAi: 3741
PRO: PR:P22460
Chemistry
GuidetoPHARMACOLOGY: 542