KCNA5 - Potassium voltage-gated channel subfamily A member 5 - human protein (Function)
 
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KCNA5 »  Potassium voltage-gated channel subfamily A member 5
 
Protein also known as:  Voltage-gated potassium channel subunit Kv1.5.
Gene name:  KCNA5
Entry whose protein(s) existence is based on evidence at protein level
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1 93 2
GENE REF ISO

Function

 show evidences
Overview 
Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets.  
2
  • CuratedUniProtKB
Isoform  Iso 2   Exhibits a voltage-dependent recovery from inactivation and an excessive cumulative inactivation.  
2
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the voltage-gated ion channel (vic) superfamily  1.A.1.2.4  
GO molecular function 
Alpha-actinin bindingdefinition[GO:0051393]  
1
  • IPIBHF-UCL
Delayed rectifier potassium channel activitydefinition[GO:0005251]  
2
  • IMPBHF-UCL
Outward rectifier potassium channel activitydefinition[GO:0015271]  
2
  • IMPBHF-UCL
Potassium channel inhibitor activitydefinition[GO:0019870] silver  
  • IEAOrtholog Compara
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Protein kinase bindingdefinition[GO:0019901]  
1
  • IPIBHF-UCL
Receptor bindingdefinition[GO:0005102] silver  
  • IEAOrtholog Compara
Scaffold protein bindingdefinition[GO:0097110]  
2
  • IPIBHF-UCL
Voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarizationdefinition[GO:0086089]  
1
  • IMPBHF-UCL
GO biological process 
Atrial cardiac muscle cell action potentialdefinition[GO:0086014]  
1
  • IMPBHF-UCL
Membrane hyperpolarizationdefinition[GO:0060081]  
1
  • IMPBHF-UCL
Negative regulation of cytosolic calcium ion concentrationdefinition[GO:0051481] silver  
  • IEAOrtholog Compara
Negative regulation of potassium ion transportdefinition[GO:0043267] silver  
  • IEAOrtholog Compara
Positive regulation of G1/S transition of mitotic cell cycledefinition[GO:1900087] silver  
  • IEAOrtholog Compara
Positive regulation of myoblast proliferationdefinition[GO:2000288] silver  
  • IEAOrtholog Compara
Potassium ion exportdefinition[GO:0071435]  
3
  • IMPBHF-UCL
Potassium ion homeostasisdefinition[GO:0055075] silver  
  • IEAOrtholog Compara
Potassium ion transportdefinition[GO:0006813]  
1
  • IDAMGI
Protein homooligomerizationdefinition[GO:0051260] silver  
  • IEAInterPro 2 GO
Regulation of atrial cardiac muscle cell membrane repolarizationdefinition[GO:0060372]  
1
  • IMPBHF-UCL
Regulation of heart rate by cardiac conductiondefinition[GO:0086091]  
1
  • IMPBHF-UCL
Regulation of insulin secretiondefinition[GO:0050796]  
1
  • TASBHF-UCL
Regulation of membrane potentialdefinition[GO:0042391]  
1
  • IDABHF-UCL
Regulation of potassium ion transportdefinition[GO:0043266]  
1
  • IMPBHF-UCL
Regulation of vasoconstrictiondefinition[GO:0019229] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathway:
Voltage gated Potassium channels  REACT_75770  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Potassium transport  definition   [KW-0633]
Transport  definition   [KW-0813]
Molecular function 
Ion channel  definition   [KW-0407]
Potassium channel  definition   [KW-0631]
Voltage-gated channel  definition   [KW-0851]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: KCNA5
GenomeRNAi: 3741
PRO: PR:P22460
Chemistry
GuidetoPHARMACOLOGY: 542