ALAS2 - 5-aminolevulinate synthase, erythroid-specific, mitochondrial - human protein (Function)
 
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ALAS2 »  5-aminolevulinate synthase, erythroid-specific, mitochondrial
 
Gene name:  ALAS2
Entry whose protein(s) existence is based on evidence at protein level
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1 36 4
GENE REF ISO

Function

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GO molecular function 
5-aminolevulinate synthase activitydefinition[GO:0003870]  
1
  • IDAUniProtKB
Coenzyme bindingdefinition[GO:0050662]  
  • ISSOrtholog Curator
Glycine bindingdefinition[GO:0016594]  
  • ISSOrtholog Curator
Protein bindingdefinition[GO:0005515]  
3
  • IPIUniProtKB
Pyridoxal phosphate bindingdefinition[GO:0030170] silver  
  • IEAInterPro 2 GO
GO biological process 
Cellular iron ion homeostasisdefinition[GO:0006879]  
  • ISSOrtholog Curator
Erythrocyte differentiationdefinition[GO:0030218]  
1
  • NASUniProtKB
  • ISSOrtholog Curator
Heme biosynthetic processdefinition[GO:0006783]  
1
  • NASUniProtKB
  • ISSOrtholog Curator
Hemoglobin biosynthetic processdefinition[GO:0042541]  
  • ISSOrtholog Curator
Oxygen homeostasisdefinition[GO:0032364]  
1
  • NASUniProtKB
Protoporphyrinogen IX biosynthetic processdefinition[GO:0006782]  
  • IEAUniPathway
Response to hypoxiadefinition[GO:0001666]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.1.37: Succinyl-CoA + glycine 5-aminolevulinate + CoA + CO(2).  
1
  • CuratedUniProtKB
It requires the following cofactor
Pyridoxal phosphate.  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Glycine, serine and threonine metabolism  hsa00260+212  
Metabolic pathways  hsa01100+212  
Porphyrin and chlorophyll metabolism  hsa00860+212  
According to Reactome, this protein belongs to the following pathway:
Heme biosynthesis  REACT_9465  
 
More information is available from:
Note 
There are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues.  
  • CuratedUniProtKB
 

Keywords

Biological process 
Heme biosynthesis  definition   [KW-0350]
Molecular function 
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ALAS2
GenomeRNAi: 212
PRO: PR:P22557