FGFR3 - Fibroblast growth factor receptor 3 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
FGFR3 »  Fibroblast growth factor receptor 3   [ EC 2.7.10.1 ]  (FGFR-3)
 
Protein also known as:  CD antigen CD333.
Gene name:  FGFR3
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 324 4
GENE REF ISO

Function

 show evidences
Overview 
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B. Secreted isoform 3 retains its capacity to bind FGF1 and FGF2 and hence may interfere with FGF signaling.  
13
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Fibroblast growth factor bindingdefinition[GO:0017134]  
2
  • IPIMGI
  • IDAUniProtKB
Fibroblast growth factor-activated receptor activitydefinition[GO:0005007]  
1
  • IMPUniProtKB
Protein bindingdefinition[GO:0005515]  
2
  • IPIIntAct
Protein tyrosine kinase activitydefinition[GO:0004713]  
1
  • IDAUniProtKB
GO biological process 
Alveolar secondary septum developmentdefinition[GO:0061144] silver  
  • IEAOrtholog Compara
Axonogenesis involved in innervationdefinition[GO:0060385] silver  
  • IEAOrtholog Compara
Bone maturationdefinition[GO:0070977]  
1
  • ISSBHF-UCL
Bone morphogenesisdefinition[GO:0060349]  
1
  • TASUniProtKB
Cell-cell signalingdefinition[GO:0007267] silver  
  • IEAOrtholog Compara
Central nervous system myelinationdefinition[GO:0022010] silver  
  • IEAOrtholog Compara
Chondrocyte differentiationdefinition[GO:0002062]  
1
  • TASUniProtKB
Chondrocyte proliferationdefinition[GO:0035988]  
1
  • TASUniProtKB
Cochlea developmentdefinition[GO:0090102] silver  
  • IEAOrtholog Compara
Digestive tract morphogenesisdefinition[GO:0048546] silver  
  • IEAOrtholog Compara
Endochondral bone growthdefinition[GO:0003416]  
1
  • TASUniProtKB
Endochondral ossificationdefinition[GO:0001958]  
1
  • TASUniProtKB
Epithelial cell fate commitmentdefinition[GO:0072148] silver  
  • IEAOrtholog Compara
Fibroblast growth factor receptor apoptotic signaling pathwaydefinition[GO:1902178]  
1
  • IMPUniProtKB
Fibroblast growth factor receptor signaling pathwaydefinition[GO:0008543]  
2
  • IDAUniProtKB
  • IGIMGI
Inner ear receptor cell differentiationdefinition[GO:0060113] silver  
  • IEAOrtholog Compara
JAK-STAT cascadedefinition[GO:0007259]  
1
  • TASPINC
Lens fiber cell developmentdefinition[GO:0070307] silver  
  • IEAOrtholog Compara
Lens morphogenesis in camera-type eyedefinition[GO:0002089] silver  
  • IEAOrtholog Compara
MAPK cascadedefinition[GO:0000165] silver  
  • IEAOrtholog Compara
Morphogenesis of an epitheliumdefinition[GO:0002009] silver  
  • IEAOrtholog Compara
Negative regulation of astrocyte differentiationdefinition[GO:0048712] silver  
  • IEAOrtholog Compara
Negative regulation of developmental growthdefinition[GO:0048640]  
1
  • ISSBHF-UCL
Negative regulation of epithelial cell proliferationdefinition[GO:0050680] silver  
  • IEAOrtholog Compara
Negative regulation of mitosisdefinition[GO:0045839] silver  
  • IEAOrtholog Compara
Negative regulation of smoothened signaling pathwaydefinition[GO:0045879] silver  
  • IEAOrtholog Compara
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
  • IEAOrtholog Compara
Peptidyl-tyrosine phosphorylationdefinition[GO:0018108]  
1
  • IDAUniProtKB
Positive regulation of canonical Wnt signaling pathwaydefinition[GO:0090263] silver  
  • IEAOrtholog Compara
Positive regulation of cell differentiationdefinition[GO:0045597] silver  
  • IEAOrtholog Compara
Positive regulation of cell proliferationdefinition[GO:0008284]  
3
  • IMPUniProtKB
  • IGIMGI
Positive regulation of endothelial cell proliferationdefinition[GO:0001938] silver  
  • IEAOrtholog Compara
Positive regulation of ERK1 and ERK2 cascadedefinition[GO:0070374]  
1
  • IMPUniProtKB
Positive regulation of MAPK cascadedefinition[GO:0043410]  
1
  • IMPUniProtKB
Positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathwaydefinition[GO:0090080] silver  
  • IEAOrtholog Compara
Positive regulation of neuron apoptotic processdefinition[GO:0043525] silver  
  • IEAOrtholog Compara
Positive regulation of phosphatidylinositol 3-kinase activitydefinition[GO:0043552]  
2
  • TASUniProtKB
Positive regulation of phospholipase activitydefinition[GO:0010518]  
1
  • IMPUniProtKB
Positive regulation of protein ubiquitinationdefinition[GO:0031398] silver  
  • IEAOrtholog Compara
Positive regulation of tyrosine phosphorylation of Stat1 proteindefinition[GO:0042511]  
2
  • IMPUniProtKB
Positive regulation of tyrosine phosphorylation of Stat3 proteindefinition[GO:0042517]  
1
  • IMPUniProtKB
Protein autophosphorylationdefinition[GO:0046777]  
1
  • IDAUniProtKB
Response to axon injurydefinition[GO:0048678] silver  
  • IEAOrtholog Compara
Skeletal system developmentdefinition[GO:0001501]  
1
  • TASPINC
Somatic stem cell maintenancedefinition[GO:0035019] silver  
  • IEAOrtholog Compara
Substantia nigra developmentdefinition[GO:0021762] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.1: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
2
  • CuratedUniProtKB
It is regulated in the following manner
Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by autophosphorylation on tyrosine residues. Inhibited by SU5402.  
3
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Bladder cancer  hsa05219+2261  
Endocytosis  hsa04144+2261  
MAPK signaling pathway  hsa04010+2261  
Pathways in cancer  hsa05200+2261  
Regulation of actin cytoskeleton  hsa04810+2261  
According to Reactome, this protein belongs to the following pathways:
Disease  REACT_116125  
Immune System  REACT_6900  
Signal Transduction  REACT_111102  
 

Keywords

Biological process 
Apoptosis  definition   [KW-0053]
Molecular function 
Kinase  definition   [KW-0418]
Receptor  definition   [KW-0675]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Fibroblast_growth_factor_receptor_3
GenomeRNAi: 2261
PRO: PR:P22607
Chemistry
GuidetoPHARMACOLOGY: 1810