PRKACG - cAMP-dependent protein kinase catalytic subunit gamma - human protein (Function)
 
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PRKACG »  cAMP-dependent protein kinase catalytic subunit gamma   [ EC 2.7.11.11 ]  (PKA C-gamma)
 
Gene name:  PRKACG
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Phosphorylates a large number of substrates in the cytoplasm and the nucleus.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
cAMP-dependent protein kinase activitydefinition[GO:0004691]  
  • IEAEC 2 GO
GO biological process 
Male gonad developmentdefinition[GO:0008584]  
1
  • TASPINC
Protein phosphorylationdefinition[GO:0006468] silver  
  • IEAInterPro 2 GO
Spermatogenesisdefinition[GO:0007283]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.11: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by cAMP.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Apoptosis  hsa04210+5568  
Calcium signaling pathway  hsa04020+5568  
Chemokine signaling pathway  hsa04062+5568  
Cholinergic synapse  hsa04725+5568  
Dopaminergic synapse  hsa04728+5568  
GABAergic synapse  hsa04727+5568  
Gap junction  hsa04540+5568  
Glutamatergic synapse  hsa04724+5568  
GnRH signaling pathway  hsa04912+5568  
Hedgehog signaling pathway  hsa04340+5568  
Insulin signaling pathway  hsa04910+5568  
Long-term potentiation  hsa04720+5568  
MAPK signaling pathway  hsa04010+5568  
Melanogenesis  hsa04916+5568  
Olfactory transduction  hsa04740+5568  
Oocyte meiosis  hsa04114+5568  
Progesterone-mediated oocyte maturation  hsa04914+5568  
Taste transduction  hsa04742+5568  
Vascular smooth muscle contraction  hsa04270+5568  
Wnt signaling pathway  hsa04310+5568  
According to Reactome, this protein belongs to the following pathways:
CREB phosphorylation through the activation of Adenylate Cyclase  REACT_20625  
DARPP-32 events  REACT_15334  
Factors involved in megakaryocyte development and platelet production  REACT_24970  
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion  REACT_18274  
Gluconeogenesis  REACT_1520  
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis  REACT_494  
Interleukin-3, 5 and GM-CSF signaling  REACT_23837  
PKA activation  REACT_15530  
PKA activation in glucagon signalling  REACT_1946  
PKA-mediated phosphorylation of CREB  REACT_15497  
PKA-mediated phosphorylation of key metabolic factors  REACT_1525  
Rap1 signalling  REACT_23898  
Regulation of insulin secretion  REACT_18325  
Regulation of water balance by renal Aquaporins  REACT_24023  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: PRKACG
GenomeRNAi: 5568
PRO: PR:P22612
Chemistry
GuidetoPHARMACOLOGY: 1478