PRKACB - cAMP-dependent protein kinase catalytic subunit beta - human protein (Function)
 
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PRKACB »  cAMP-dependent protein kinase catalytic subunit beta   [ EC 2.7.11.11 ]  (PKA C-beta)
 
Gene name:  PRKACB
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.  
3
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB
cAMP-dependent protein kinase activitydefinition[GO:0004691]  
1
  • UniProtKB
Magnesium ion bindingdefinition[GO:0000287]  
1
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
4
  • IntAct
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • UniProtKB
GO biological process 
Adenylate cyclase-modulating G-protein coupled receptor signaling pathwaydefinition[GO:0007188]  
1
  • UniProtKB
Negative regulation of meiotic cell cycledefinition[GO:0051447] silver  
1
  • Ortholog Compara
Negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterningdefinition[GO:1901621] silver  
1
  • Ortholog Compara
Neural tube closuredefinition[GO:0001843] silver  
1
  • Ortholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • UniProtKB
Regulation of protein processingdefinition[GO:0070613] silver  
1
  • Ortholog Compara
Response to clozapinedefinition[GO:0097338] silver  
1
  • Ortholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.11: ATP + a protein ADP + a phosphoprotein.  
1
  • UniProtKB
It requires the following cofactor
 Mg(2+)  
1
  • UniProtKB
It is regulated in the following manner
Activated by cAMP.  
1
  • UniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Apoptosis  hsa04210+5567  
Calcium signaling pathway  hsa04020+5567  
Chemokine signaling pathway  hsa04062+5567  
Cholinergic synapse  hsa04725+5567  
Dopaminergic synapse  hsa04728+5567  
GABAergic synapse  hsa04727+5567  
Gap junction  hsa04540+5567  
Glutamatergic synapse  hsa04724+5567  
GnRH signaling pathway  hsa04912+5567  
Hedgehog signaling pathway  hsa04340+5567  
Insulin signaling pathway  hsa04910+5567  
Long-term potentiation  hsa04720+5567  
MAPK signaling pathway  hsa04010+5567  
Melanogenesis  hsa04916+5567  
Olfactory transduction  hsa04740+5567  
Oocyte meiosis  hsa04114+5567  
Progesterone-mediated oocyte maturation  hsa04914+5567  
Taste transduction  hsa04742+5567  
Vascular smooth muscle contraction  hsa04270+5567  
Wnt signaling pathway  hsa04310+5567  
According to Reactome, this protein belongs to the following pathways:
CD209 (DC-SIGN) signaling  R-HSA-5621575  
CREB phosphorylation through the activation of Adenylate Cyclase  R-HSA-442720  
DARPP-32 events  R-HSA-180024  
Degradation of GLI1 by the proteasome  R-HSA-5610780  
Degradation of GLI2 by the proteasome  R-HSA-5610783  
Factors involved in megakaryocyte development and platelet production  R-HSA-983231  
GLI3 is processed to GLI3R by the proteasome  R-HSA-5610785  
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion  R-HSA-381676  
Gluconeogenesis  R-HSA-70263  
Hedgehog 'off' state  R-HSA-5610787  
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis  R-HSA-163560  
MAPK6/MAPK4 signaling  R-HSA-5687128  
PKA activation  R-HSA-163615  
PKA activation in glucagon signalling  R-HSA-164378  
PKA-mediated phosphorylation of CREB  R-HSA-111931  
PKA-mediated phosphorylation of key metabolic factors  R-HSA-163358  
Rap1 signalling  R-HSA-392517  
Regulation of insulin secretion  R-HSA-422356  
Vasopressin regulates renal water homeostasis via Aquaporins  R-HSA-432040  
VEGFA-VEGFR2 Pathway  R-HSA-4420097  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P22694
Other
GeneWiki: PRKACB
GenomeRNAi: 5567
PRO: PR:P22694
Chemistry
GuidetoPHARMACOLOGY: 1477