PRKACB - cAMP-dependent protein kinase catalytic subunit beta - human protein (Function)
 
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PRKACB »  cAMP-dependent protein kinase catalytic subunit beta   [ EC 2.7.11.11 ]  (PKA C-beta)
 
Gene name:  PRKACB
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.  
2
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • IDAUniProtKB
cAMP-dependent protein kinase activitydefinition[GO:0004691]  
1
  • IDAUniProtKB
Magnesium ion bindingdefinition[GO:0000287]  
1
  • IDAUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • IDAUniProtKB
GO biological process 
Adenylate cyclase-modulating G-protein coupled receptor signaling pathwaydefinition[GO:0007188]  
1
  • TASUniProtKB
Negative regulation of meiotic cell cycledefinition[GO:0051447] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • IDAUniProtKB
Response to clozapinedefinition[GO:0097338] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.11.11: ATP + a protein ADP + a phosphoprotein.  
  • CuratedUniProtKB
It requires the following cofactor
Magnesium.  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by cAMP.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Apoptosis  hsa04210+5567  
Calcium signaling pathway  hsa04020+5567  
Chemokine signaling pathway  hsa04062+5567  
Cholinergic synapse  hsa04725+5567  
Dopaminergic synapse  hsa04728+5567  
GABAergic synapse  hsa04727+5567  
Gap junction  hsa04540+5567  
Glutamatergic synapse  hsa04724+5567  
GnRH signaling pathway  hsa04912+5567  
Hedgehog signaling pathway  hsa04340+5567  
Insulin signaling pathway  hsa04910+5567  
Long-term potentiation  hsa04720+5567  
MAPK signaling pathway  hsa04010+5567  
Melanogenesis  hsa04916+5567  
Olfactory transduction  hsa04740+5567  
Oocyte meiosis  hsa04114+5567  
Progesterone-mediated oocyte maturation  hsa04914+5567  
Taste transduction  hsa04742+5567  
Vascular smooth muscle contraction  hsa04270+5567  
Wnt signaling pathway  hsa04310+5567  
According to Reactome, this protein belongs to the following pathways:
CREB phosphorylation through the activation of Adenylate Cyclase  REACT_20625  
DARPP-32 events  REACT_15334  
Factors involved in megakaryocyte development and platelet production  REACT_24970  
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion  REACT_18274  
Gluconeogenesis  REACT_1520  
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis  REACT_494  
Interleukin-3, 5 and GM-CSF signaling  REACT_23837  
PKA activation  REACT_15530  
PKA activation in glucagon signalling  REACT_1946  
PKA-mediated phosphorylation of CREB  REACT_15497  
PKA-mediated phosphorylation of key metabolic factors  REACT_1525  
Rap1 signalling  REACT_23898  
Regulation of insulin secretion  REACT_18325  
Regulation of water balance by renal Aquaporins  REACT_24023  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Serine/threonine-protein kinase  definition   [KW-0723]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: PRKACB
GenomeRNAi: 5567
PRO: PR:P22694
Chemistry
GuidetoPHARMACOLOGY: 1477