TGM1 - Protein-glutamine gamma-glutamyltransferase K - human protein (Function)
 
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TGM1 »  Protein-glutamine gamma-glutamyltransferase K   [ EC 2.3.2.13 ]
 
Protein also known as:  Transglutaminase-1 (TGase-1).
Gene name:  TGM1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Responsible for cross-linking epidermal proteins during formation of the stratum corneum.  
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  • UniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
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  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
4
  • UniProtKB
Protein-glutamine gamma-glutamyltransferase activitydefinition[GO:0003810]  
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  • UniProtKB
GO biological process 
Cell envelope organizationdefinition[GO:0043163]  
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  • UniProtKB
Cellular protein modification processdefinition[GO:0006464]  
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  • UniProtKB
Keratinizationdefinition[GO:0031424]  
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  • UniProtKB KW
Keratinocyte differentiationdefinition[GO:0030216]  
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  • UniProtKB
Organ morphogenesisdefinition[GO:0009887] silver  
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  • Ortholog Compara
Peptide cross-linkingdefinition[GO:0018149] silver  
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  • InterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.3.2.13: Protein glutamine + alkylamine protein N(5)-alkylglutamine + NH(3).  
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  • PROSITE-ProRule
  • UniProtKB
It requires the following cofactor
 Ca(2+) : Binds 1 Ca(2+) ion per subunit.  
1
  • UniProtKB
 

Keywords

Biological process 
Keratinization  definition   [KW-0417]
Molecular function 
Acyltransferase  definition   [KW-0012]
Transferase  definition   [KW-0808]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links