CA4 - Carbonic anhydrase 4 - human protein (Function)
 
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Protein
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CA4 »  Carbonic anhydrase 4   [ EC 4.2.1.1 ]
 
Protein also known as:  Carbonate dehydratase IV.
Gene name:  CA4
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Reversible hydration of carbon dioxide. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid.  
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  • CuratedUniProtKB
GO molecular function 
Protein bindingdefinition[GO:0005515]  
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  • IPIDFLAT
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Bicarbonate transportdefinition[GO:0015701]  
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  • IMPDFLAT
One-carbon metabolic processdefinition[GO:0006730] silver  
  • IEAInterPro 2 GO
Organ developmentdefinition[GO:0048513] silver  
  • IEAOrtholog Compara
Response to drugdefinition[GO:0042493] silver  
  • IEAOrtholog Compara
Response to steroid hormonedefinition[GO:0048545] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.2.1.1: H(2)CO(3) CO(2) + H(2)O.  
  • CuratedUniProtKB
It requires the following cofactor
Zinc.  
  • CuratedUniProtKB
It is regulated in the following manner
Activated by histamine, L-adrenaline, D-phenylalanine, L- and D-histidine. Inhibited by coumarins, saccharin, sulfonamide derivatives such as acetazolamide and Foscarnet (phosphonoformate trisodium salt).  
8
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Nitrogen metabolism  hsa00910+762  
Proximal tubule bicarbonate reclamation  hsa04964+762  
According to Reactome, this protein belongs to the following pathways:
Erythrocytes take up carbon dioxide and release oxygen  REACT_121329  
Erythrocytes take up oxygen and release carbon dioxide  REACT_121380  
Reversible hydration of carbon dioxide  REACT_121123  
 

Biophysicochemical properties

Kinetic parameters
KM 21.5 mM for CO(2)

Keywords

Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P22748
Other
GeneWiki: Carbonic_anhydrase_4
GenomeRNAi: 762
PRO: PR:P22748
Chemistry
GuidetoPHARMACOLOGY: 2599