AADAC - Arylacetamide deacetylase - human protein (Function)
 
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Protein
Gene
References

 
AADAC »  Arylacetamide deacetylase   [ EC 3.1.1.3 ]
 
Gene name:  AADAC
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.  
5
  • CuratedUniProtKB
GO molecular function 
Catalytic activitydefinition[GO:0003824]  
1
  • TASPINC
Deacetylase activitydefinition[GO:0019213]  
1
  • IDAUniProtKB
Lipase activitydefinition[GO:0016298]  
1
  • TASUniProtKB
Serine hydrolase activitydefinition[GO:0017171]  
1
  • IDAUniProtKB
Triglyceride lipase activitydefinition[GO:0004806]  
  • ISSOrtholog Curator
GO biological process 
Metabolic processdefinition[GO:0008152] silver  
  • IEAInterPro 2 GO
Positive regulation of triglyceride catabolic processdefinition[GO:0010898]  
  • ISSOrtholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.1.3: Triacylglycerol + H(2)O diacylglycerol + a carboxylate.  
  • CuratedUniProtKB
 
More information is available from:
Note 
Can hydrolyze a number of clinical drugs such as flutamide, an antiandrogen drug used for the treatment of prostate cancer; phenacetin, an analgesic antipyretic which has been withdrawn from the market due to its links with renal failure; and rifamycins which have been used as antituberculosis drugs.  
  • CuratedUniProtKB
 

Biophysicochemical properties

Kinetic parameters
KM 1.42 mM for phenacetin (PubMed:22415931)
KM 0.154 mM for rifampicin (PubMed:22415931)
KM 0.6 mM for flutamide (PubMed:22207054)
KM 0.472 mM for flutamide (PubMed:22415931)
KM 1.8 mM for phenacetin (PubMed:22207054)
KM 0.8 mM for flutamide (PubMed:19339378)
KM 0.2 mM for rifampicin (PubMed:22207054)
KM 3.05 mM for phenacetin (PubMed:24125761)
Vmax 1.1 nmol/min/mg enzyme toward flutamide (PubMed:22207054)
Vmax 6.4 nmol/min/mg enzyme toward phenacetin (PubMed:22207054)
Vmax 1.42 nmol/min/mg enzyme toward phenacetin (PubMed:22415931)
Vmax 0.617 nmol/min/mg enzyme toward flutamide (PubMed:22415931)
Vmax 1.1 nmol/min/mg enzyme toward flutamide (PubMed:19339378)
Vmax 1.34 nmol/min/mg enzyme toward phenacetin (PubMed:24125761)
Vmax 0.060 nmol/min/mg enzyme toward rifampicin (PubMed:22415931)
Vmax 0.149 nmol/min/mg enzyme toward rifampicin (PubMed:22207054)

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P22760
Other
GeneWiki: AADAC
GenomeRNAi: 13
PRO: PR:P22760