AADAC - Arylacetamide deacetylase - human protein (Function)
 
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AADAC »  Arylacetamide deacetylase   [ EC 3.1.1.3 ]
 
Gene name:  AADAC
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.  
6
  • UniProtKB
GO molecular function 
Catalytic activitydefinition[GO:0003824]  
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  • PINC
Deacetylase activitydefinition[GO:0019213]  
1
  • UniProtKB
Lipase activitydefinition[GO:0016298]  
1
  • UniProtKB
Serine hydrolase activitydefinition[GO:0017171]  
1
  • UniProtKB
Triglyceride lipase activitydefinition[GO:0004806]  
1
  • Ortholog Curator
GO biological process 
Metabolic processdefinition[GO:0008152] silver  
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  • InterPro 2 GO
Positive regulation of triglyceride catabolic processdefinition[GO:0010898]  
1
  • Ortholog Curator
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.1.1.3: Triacylglycerol + H(2)O diacylglycerol + a carboxylate.  
1
  • UniProtKB
 
More information is available from:
Note 
Can hydrolyze a number of clinical drugs such as flutamide, an antiandrogen drug used for the treatment of prostate cancer; phenacetin, an analgesic antipyretic which has been withdrawn from the market due to its links with renal failure; and rifamycins which have been used as antituberculosis drugs.  
1
  • UniProtKB
 

Biophysicochemical properties

Kinetic parameters
KM 3.05 mM for phenacetin
KM 0.2 mM for rifampicin
KM 1.8 mM for phenacetin
KM 0.8 mM for flutamide
KM 1.42 mM for phenacetin
KM 0.154 mM for rifampicin
KM 0.6 mM for flutamide
KM 0.472 mM for flutamide
Vmax 0.149 nmol/min/mg enzyme toward rifampicin
Vmax 1.34 nmol/min/mg enzyme toward phenacetin
Vmax 6.4 nmol/min/mg enzyme toward phenacetin
Vmax 0.060 nmol/min/mg enzyme toward rifampicin
Vmax 0.617 nmol/min/mg enzyme toward flutamide
Vmax 1.42 nmol/min/mg enzyme toward phenacetin
Vmax 1.1 nmol/min/mg enzyme toward flutamide

Keywords

Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P22760
Other
GeneWiki: AADAC
GenomeRNAi: 13
PRO: PR:P22760