MMP8 - Neutrophil collagenase - human protein (Function)
 
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MMP8 »  Neutrophil collagenase   [ EC 3.4.24.34 ]
 
Protein also known as:  Matrix metalloproteinase-8 (MMP-8).
Gene name:  MMP8
Family name: Peptidase M10A
Entry whose protein(s) existence is based on evidence at protein level
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1 117 1
GENE REF ISO

Function

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Overview 
Can degrade fibrillar type I, II, and III collagens.  
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Metalloendopeptidase activitydefinition[GO:0004222] silver  
  • IEAInterPro 2 GO
Serine-type endopeptidase activitydefinition[GO:0004252]  
2
  • IDAUniProtKB
Zinc ion bindingdefinition[GO:0008270]  
1
  • TASUniProtKB
GO biological process 
Proteolysisdefinition[GO:0006508]  
1
  • IDAUniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.4.24.34: Cleavage of interstitial collagens in the triple helical domain. Unlike EC 3.4.24.7, this enzyme cleaves type III collagen more slowly than type I.  
  • CuratedUniProtKB
It requires the following cofactors
Binds 3 calcium ions per subunit.  
  • CuratedUniProtKB
Binds 2 zinc ions per subunit.  
  • CuratedUniProtKB
It is regulated in the following manner
Cannot be activated without removal of the activation peptide.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to Reactome, this protein belongs to the following pathways:
Activation of Matrix Metalloproteinases  REACT_118682  
Collagen degradation  REACT_150401  
Degradation of the extracellular matrix  REACT_118572  
 

Keywords

Biological process 
Collagen degradation  definition   [KW-0177]
Molecular function 
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: MMP8
GenomeRNAi: 4317
PRO: PR:P22894
Chemistry
GuidetoPHARMACOLOGY: 1632