XPA - DNA repair protein complementing XP-A cells - human protein (Function)
 
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Protein
Gene
References

 
XPA »  DNA repair protein complementing XP-A cells
 
Protein also known as:  Xeroderma pigmentosum group A-complementing protein.
Gene name:  XPA
Family name: XPA
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 105 1
GENE REF ISO

Function

 show evidences
Overview 
Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHEK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.  
1
  • CuratedUniProtKB
GO molecular function 
Damaged DNA bindingdefinition[GO:0003684]  
1
  • IDAUniProtKB
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
9
  • IPIIntAct
  • IPIUniProtKB
Protein domain specific bindingdefinition[GO:0019904]  
1
  • IPIUniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • IPIUniProtKB
GO biological process 
Intrinsic apoptotic signaling pathway in response to DNA damagedefinition[GO:0008630] silver  
  • IEAOrtholog Compara
Multicellular organism growthdefinition[GO:0035264] silver  
  • IEAOrtholog Compara
Response to oxidative stressdefinition[GO:0006979] silver  
  • IEAOrtholog Compara
Response to toxic substancedefinition[GO:0009636] silver  
  • IEAOrtholog Compara
Response to UVdefinition[GO:0009411] silver  
  • IEAOrtholog Compara
Pathways 
According to Reactome, this protein belongs to the following pathways:
Dual incision reaction in GG-NER  REACT_311  
Formation of incision complex in GG-NER  REACT_257  
 

Keywords

Biological process 
DNA damage  definition   [KW-0227]
DNA repair  definition   [KW-0234]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: XPA
GenomeRNAi: 7507
PRO: PR:P23025