AMPD1 - AMP deaminase 1 - human protein (Function)
 
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Protein
Gene
References

 
AMPD1 »  AMP deaminase 1   [ EC 3.5.4.6 ]
 
Protein also known as:  AMP deaminase isoform M.
Gene name:  AMPD1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
AMP deaminase plays a critical role in energy metabolism.  
  • CuratedUniProtKB
GO molecular function 
AMP deaminase activitydefinition[GO:0003876]  
  • IEAEC 2 GO
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Myosin heavy chain bindingdefinition[GO:0032036] silver  
  • IEAOrtholog Compara
GO biological process 
IMP salvagedefinition[GO:0032264]  
  • IEAUniPathway
Response to organic substancedefinition[GO:0010033] silver  
  • IEAOrtholog Compara
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.5.4.6: AMP + H(2)O IMP + NH(3).  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Metabolic pathways  hsa01100+270  
Purine metabolism  hsa00230+270  
According to Reactome, this protein belongs to the following pathway:
Purine salvage  REACT_1923  
 

Keywords

Biological process 
Nucleotide metabolism  definition   [KW-0546]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P23109
Other
GeneWiki: AMP_deaminase
GenomeRNAi: 270
PRO: PR:P23109