FBLN1 - Fibulin-1 - human protein (Function)
 
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Protein
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FBLN1 »  Fibulin-1  (FIBL-1)
 
Gene name:  FBLN1
Family name: Fibulin
Entry whose protein(s) existence is based on evidence at protein level
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1 66 4
GENE REF ISO

Function

 show evidences
Overview 
Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP.  
4
  • CuratedUniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509] silver  
  • IEAInterPro 2 GO
Extracellular matrix structural constituentdefinition[GO:0005201]  
1
  • TASPINC
Peptidase activator activitydefinition[GO:0016504] silver  
  • IEAOrtholog Compara
GO biological process 
Embryo implantationdefinition[GO:0007566] silver  
  • IEAOrtholog Compara
Positive regulation of peptidase activitydefinition[GO:0010952] silver  
  • IEAOrtholog Compara
Viral processdefinition[GO:0016032]  
  • IEAUniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathway:
Molecules associated with elastic fibres  REACT_150331  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FBLN1
GenomeRNAi: 2192
PRO: PR:P23142