FBLN1 - Fibulin-1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Protein
Gene
References

 
FBLN1 »  Fibulin-1  (FIBL-1)
 
Gene name:  FBLN1
Family name: Fibulin
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 84 4
GENE REF ISO

Function

 show evidences
Overview 
Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. Has been implicated in a role in cellular transformation and tumor invasion, it appears to be a tumor suppressor. May play a role in haemostasis and thrombosis owing to its ability to bind fibrinogen and incorporate into clots. Could play a significant role in modulating the neurotrophic activities of APP, particularly soluble APP.  
4
  • UniProtKB
GO molecular function 
Calcium ion bindingdefinition[GO:0005509]  
1
  • UniProtKB
Extracellular matrix structural constituentdefinition[GO:0005201]  
1
  • UniProtKB
Fibrinogen bindingdefinition[GO:0070051]  
1
  • UniProtKB
Fibronectin bindingdefinition[GO:0001968]  
2
  • UniProtKB
Identical protein bindingdefinition[GO:0042802]  
3
  • UniProtKB
Isoforms  D and C   Integrin bindingdefinition[GO:0005178]  
1
  • UniProtKB
Peptidase activator activitydefinition[GO:0016504] silver  
1
  • Ortholog Compara
Isoforms  D and C   Protein bindingdefinition[GO:0005515]  
2
  • UniProtKB
Protein C-terminus bindingdefinition[GO:0008022]  
2
  • UniProtKB
Protein complex bindingdefinition[GO:0032403]  
1
  • UniProtKB
GO biological process 
Blood coagulation, fibrin clot formationdefinition[GO:0072378]  
1
  • UniProtKB
Embryo implantationdefinition[GO:0007566] silver  
1
  • Ortholog Compara
Not  Integrin-mediated signaling pathwaydefinition[GO:0007229]  
1
  • UniProtKB
Negative regulation of cell adhesiondefinition[GO:0007162]  
1
  • UniProtKB
Negative regulation of cell motilitydefinition[GO:2000146]  
1
  • UniProtKB
Negative regulation of ERK1 and ERK2 cascadedefinition[GO:0070373]  
1
  • UniProtKB
Negative regulation of protein phosphorylationdefinition[GO:0001933]  
1
  • UniProtKB
Negative regulation of stem cell proliferationdefinition[GO:2000647]  
1
  • UniProtKB
Negative regulation of substrate adhesion-dependent cell spreadingdefinition[GO:1900025]  
1
  • UniProtKB
Isoform  D   Negative regulation of transformation of host cell by virusdefinition[GO:1904188]  
1
  • UniProtKB
Isoform  C   Negative regulation of transforming growth factor-beta secretiondefinition[GO:2001202]  
1
  • UniProtKB
Isoform  C   Positive regulation of fibroblast proliferationdefinition[GO:0048146]  
1
  • UniProtKB
Isoform  C   Positive regulation of gene expressiondefinition[GO:0010628]  
1
  • UniProtKB
Positive regulation of peptidase activitydefinition[GO:0010952]  
2
  • InterPro 2 GO
  • Ortholog Compara
Isoform  C   Positive regulation of substrate-dependent cell migration, cell attachment to substratedefinition[GO:1904237]  
1
  • UniProtKB
Viral processdefinition[GO:0016032]  
1
  • UniProtKB KW
Pathways 
According to Reactome, this protein belongs to the following pathway:
Molecules associated with elastic fibres  R-HSA-2129379  
 

Keywords

Biological process 
Host-virus interaction  definition   [KW-0945]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: FBLN1
GenomeRNAi: 2192
PRO: PR:P23142