KEL - Kell blood group glycoprotein - human protein (Function)
 
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KEL »  Kell blood group glycoprotein   [ EC 3.4.24.- ]
 
Protein also known as:  CD antigen CD238.
Gene name:  KEL
Family name: Peptidase M13
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Zinc endopeptidase with endothelin-3-converting enzyme activity. Cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3.  
1
  • CuratedUniProtKB
GO molecular function 
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Metalloendopeptidase activitydefinition[GO:0004222]  
1
  • IDAHGNC
Protein bindingdefinition[GO:0005515]  
1
  • IPIHGNC
GO biological process 
Vasoconstrictiondefinition[GO:0042310]  
1
  • TASHGNC
Enzymatic activity 
It requires the following cofactor
Binds 1 zinc ion per subunit (By similarity).  
  • CuratedUniProtKB
 
More information is available from:
 

Keywords

Molecular function 
Blood group antigen  definition   [KW-0095]
Hydrolase  definition   [KW-0378]
Metalloprotease  definition   [KW-0482]
Protease  definition   [KW-0645]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GenomeRNAi: 3792
PRO: PR:P23276