CA6 - Carbonic anhydrase 6 - human protein (Function)
 
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Protein
Gene
References

 
CA6 »  Carbonic anhydrase 6   [ EC 4.2.1.1 ]
 
Protein also known as:  Salivary carbonic anhydrase.
Gene name:  CA6
Entry whose protein(s) existence is based on evidence at protein level
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1 30 3
GENE REF ISO

Function

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Overview 
Reversible hydration of carbon dioxide. Its role in saliva is unknown.  
  • CuratedUniProtKB
GO molecular function 
Zinc ion bindingdefinition[GO:0008270] silver  
  • IEAInterPro 2 GO
GO biological process 
Detection of chemical stimulus involved in sensory perception of bitter tastedefinition[GO:0001580]  
1
  • IDAUniProtKB
One-carbon metabolic processdefinition[GO:0006730] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 4.2.1.1: H(2)CO(3) CO(2) + H(2)O.  
  • CuratedUniProtKB
It requires the following cofactor
Zinc (By similarity).  
  • CuratedUniProtKB
It is regulated in the following manner
Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), saccharin and Foscarnet (phosphonoformate trisodium salt).  
4
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathway:
Nitrogen metabolism  hsa00910+765  
According to Reactome, this protein belongs to the following pathway:
Reversible hydration of carbon dioxide  REACT_121123  
 

Keywords

Molecular function 
Lyase  definition   [KW-0456]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Carbonic_anhydrase_VI
GenomeRNAi: 765
PRO: PR:P23280