PPIB - Peptidyl-prolyl cis-trans isomerase B - human protein (Function)
 
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PPIB »  Peptidyl-prolyl cis-trans isomerase B   [ EC 5.2.1.8 ]  (PPIase B)
 
Protein also known as:  Cyclophilin B.
Gene name:  PPIB
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.  
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  • UniProtKB
GO molecular function 
Contributes to collagen bindingdefinition[GO:0005518]  
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  • Ortholog Curator
Peptide bindingdefinition[GO:0042277]  
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  • UniProtKB KW
Peptidyl-prolyl cis-trans isomerase activitydefinition[GO:0003755]  
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  • UniProtKB
  • Ortholog Curator
  • RefGenome
Poly(A) RNA bindingdefinition[GO:0044822]  
2
  • UniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
  • UniProtKB
  • BHF-UCL
Protein complex bindingdefinition[GO:0032403]  
1
  • Ortholog Curator
Unfolded protein bindingdefinition[GO:0051082]  
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  • PINC
GO biological process 
Bone developmentdefinition[GO:0060348]  
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  • UniProtKB
Contradiction  Chaperone-mediated protein foldingdefinition[GO:0061077]  
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  • UniProtKB
Positive regulation of multicellular organism growthdefinition[GO:0040018]  
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  • UniProtKB
Protein peptidyl-prolyl isomerizationdefinition[GO:0000413]  
2
  • Ortholog Curator
  • RefGenome
Protein stabilizationdefinition[GO:0050821]  
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  • UniProtKB
Not  Regulation of post-translational protein modificationdefinition[GO:1901873]  
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  • UniProtKB
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.2.1.8: Peptidylproline (omega180) peptidylproline (omega0).  
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  • UniProtKB
It is regulated in the following manner
Cyclosporin A (CsA) inhibits CYPB.  
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  • UniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Collagen biosynthesis and modifying enzymes  REACT_121139  
 

Keywords

Molecular function 
Isomerase  definition   [KW-0413]
Rotamase  definition   [KW-0697]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PPIB
GenomeRNAi: 5479
PRO: PR:P23284