PPIB - Peptidyl-prolyl cis-trans isomerase B - human protein (Function)
 
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PPIB »  Peptidyl-prolyl cis-trans isomerase B   [ EC 5.2.1.8 ]  (PPIase B)
 
Protein also known as:  Cyclophilin B.
Gene name:  PPIB
Entry whose protein(s) existence is based on evidence at protein level
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1 58 1
GENE REF ISO

Function

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Overview 
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.  
  • CuratedUniProtKB
GO molecular function 
Peptide bindingdefinition[GO:0042277]  
  • IEAUniProtKB KW
Peptidyl-prolyl cis-trans isomerase activitydefinition[GO:0003755]  
1
  • NASUniProtKB
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
  • IPIBHF-UCL
Unfolded protein bindingdefinition[GO:0051082]  
1
  • TASPINC
GO biological process 
Protein foldingdefinition[GO:0006457]  
  • IEAUniProtKB KW
Protein peptidyl-prolyl isomerizationdefinition[GO:0000413]  
1
  • NASGOC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 5.2.1.8: Peptidylproline (omega180) peptidylproline (omega0).  
  • CuratedUniProtKB
It is regulated in the following manner
Cyclosporin A (CsA) inhibits CYPB.  
  • CuratedUniProtKB
Pathways 
According to Reactome, this protein belongs to the following pathway:
Extracellular matrix organization  REACT_118779  
 

Keywords

Molecular function 
Isomerase  definition   [KW-0413]
Rotamase  definition   [KW-0697]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: PPIB
GenomeRNAi: 5479
PRO: PR:P23284