S100A1 - Protein S100-A1 - human protein (Function)
 
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S100A1 »  Protein S100-A1
 
Protein also known as:  S100 calcium-binding protein A1.
Gene name:  S100A1
Family name: S-100
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity.  
2
  • UniProtKB
GO molecular function 
ATPase bindingdefinition[GO:0051117]  
1
  • UniProtKB
Calcium ion bindingdefinition[GO:0005509] silver  
1
  • InterPro 2 GO
Calcium-dependent protein bindingdefinition[GO:0048306] silver  
1
  • Ortholog Compara
Identical protein bindingdefinition[GO:0042802]  
5
  • IntAct
Protein bindingdefinition[GO:0005515]  
6
  • IntAct
  • UniProtKB
Protein homodimerization activitydefinition[GO:0042803]  
1
  • UniProtKB
S100 protein bindingdefinition[GO:0044548]  
1
  • UniProtKB
GO biological process 
Intracellular signal transductiondefinition[GO:0035556]  
1
  • UniProtKB
Negative regulation of transcription from RNA polymerase II promoterdefinition[GO:0000122] silver  
1
  • Ortholog Compara
Positive regulation of voltage-gated calcium channel activitydefinition[GO:1901387] silver  
1
  • Ortholog Compara
Regulation of heart contractiondefinition[GO:0008016]  
1
  • UniProtKB
Substantia nigra developmentdefinition[GO:0021762]  
1
  • UniProtKB
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links