ME2 - NAD-dependent malic enzyme, mitochondrial - human protein (Function)
 
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ME2 »  NAD-dependent malic enzyme, mitochondrial   [ EC 1.1.1.38 ]  (NAD-ME)
 
Protein also known as:  Malic enzyme 2.
Gene name:  ME2
Family name: Malic enzymes
Entry whose protein(s) existence is based on evidence at protein level
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1 30 2
GENE REF ISO

Function

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GO molecular function 
Electron carrier activitydefinition[GO:0009055]  
1
  • TASUniProtKB
Malate dehydrogenase (decarboxylating) (NAD+) activitydefinition[GO:0004471]  
  • IEAEC 2 GO
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
NAD bindingdefinition[GO:0051287] silver  
  • IEAInterPro 2 GO
Oxaloacetate decarboxylase activitydefinition[GO:0008948]  
  • IEAEC 2 GO
GO biological process 
Malate metabolic processdefinition[GO:0006108] silver  
  • IEAInterPro 2 GO
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
(S)-malate + NAD(+) pyruvate + CO(2) + NADH.  
  • CuratedUniProtKB
Oxaloacetate pyruvate + CO(2).  
  • CuratedUniProtKB
It requires the following cofactor
Divalent metal cations. Prefers magnesium or manganese.  
  • CuratedUniProtKB
It is regulated in the following manner
Subject to allosteric activation by fumarate.  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Pyruvate metabolism  hsa00620+4200  
Note 
This isoenzyme can also use NADP(+) but is more effective with NAD(+).  
  • CuratedUniProtKB
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Allosteric enzyme  definition   [KW-0021]
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P23368
Other
GeneWiki: ME2_(gene)
GeneWiki: ME2
GenomeRNAi: 4200
PRO: PR:P23368