ME2 - NAD-dependent malic enzyme, mitochondrial - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
ME2 »  NAD-dependent malic enzyme, mitochondrial   [ EC 1.1.1.38 ]  (NAD-ME)
 
Protein also known as:  Malic enzyme 2.
Gene name:  ME2
Family name: Malic enzymes
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 30 2
GENE REF ISO

Function

 show evidences
GO molecular function 
Electron carrier activitydefinition[GO:0009055]  
1
  • UniProtKB
Malate dehydrogenase (decarboxylating) (NAD+) activitydefinition[GO:0004471]  
1
  • EC 2 GO
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
NAD bindingdefinition[GO:0051287] silver  
1
  • InterPro 2 GO
Oxaloacetate decarboxylase activitydefinition[GO:0008948]  
1
  • EC 2 GO
GO biological process 
Malate metabolic processdefinition[GO:0006108] silver  
1
  • InterPro 2 GO
Oxidation-reduction processdefinition[GO:0055114]  
1
  • UniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reactions
(S)-malate + NAD(+) pyruvate + CO(2) + NADH.  
1
  • UniProtKB
Oxaloacetate pyruvate + CO(2).  
1
  • UniProtKB
It requires the following cofactor
 Mg(2+) : Divalent metal cations. Prefers magnesium or manganese.  
1
  • UniProtKB
It is regulated in the following manner
Subject to allosteric activation by fumarate.  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathway:
Pyruvate metabolism  hsa00620+4200  
Note 
This isoenzyme can also use NADP(+) but is more effective with NAD(+).  
1
  • UniProtKB
 

Keywords

Molecular function 
Oxidoreductase  definition   [KW-0560]
Technical term 
Allosteric enzyme  definition   [KW-0021]
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P23368
Other
GeneWiki: ME2_(gene)
GeneWiki: ME2
GenomeRNAi: 4200
PRO: PR:P23368