RPS3 - 40S ribosomal protein S3 - human protein (Interactions)
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RPS3 »  40S ribosomal protein S3   [ EC ]
Gene name:  RPS3
Family name: Ribosomal protein S3P
Entry whose protein(s) existence is based on evidence at protein level
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Component of the 40S small ribosomal subunit (PubMed8706699). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed17289661). Interacts with HNRPD (PubMed:24423872). Interacts with PRMT1; the interaction methylates RPS3 (PubMed19460357). Interacts with SUMO1; the interaction sumoylates RPS3 (PubMed21968017). Interacts with UBC9 (PubMed21968017). Interacts with CDK1; the interaction phosphorylates RPS3 (PubMed21871177). Interacts with PRKCD; the interaction phosphorylates RPS3 (PubMed19059439). Interacts with PKB/AKT; the interaction phosphorylates RPS3 (PubMed20605787). Interacts with E2F1; the interaction occurs in the absence of nerve growth factor and increases transcription of pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed20605787). Interacts with the base excision repair proteins APEX1 and OGG1; interaction with OGG1 increases OGG1 N-glycosylase activity (PubMed15518571). Interacts with UNG; the interaction increases the uracil excision activity of UNG1 (PubMed18973764). Interacts with HSP90; the interaction prevents the ubiquitination and proteasome-dependent degradation of RPS3 and is suppressed by increased ROS levels (PubMed16314389). Interacts with TOM70; the interaction promotes translocation of RPS3 to the mitochondrion (PubMed23911537). Interacts (via N-terminus) with RELA (via N-terminus); the interaction enhances the DNA-binding activity of the NF-kappa-B p65-p50 complex (PubMed18045535). Interacts with NFKBIA; the interaction is direct and may bridge the interaction between RPS3 and RELA (PubMed24457201). Interacts with IKKB; the interaction phosphorylates RPS3 and enhances its translocation to the nucleus (PubMed21399639). Interacts (via KH domain) with MDM2 and TP53 (PubMed19656744). Interacts with TRADD (PubMed22510408). Interacts (via N-terminus) with E.coli O157:H7 (strain EDL933) nleH1 and nleH2; the interaction with nleH1 inhibits phosphorylation by IKKB, reduces RPS3 nuclear abundance and inhibits transcriptional activation by the NF-kappa-B p65-p50 complex (PubMed20041225, PubMed21399639). Identified in a HCV IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon (PubMed19541769). Interacts with CRY1 (By similarity).  
  • UniProtKB

Binary interactions

Interaction target Number of
Itself 3 IntAct: EBI-351193,EBI-351193
AGO1  » Protein argonaute-1 silver 3 IntAct: EBI-351193,EBI-527363
AGO2  » Protein argonaute-2 silver 2 IntAct: EBI-351193,EBI-528269
ARRB2  » Beta-arrestin-2 silver 2 IntAct: EBI-351193,EBI-714559
ATP6V0D2  » V-type proton ATPase subunit d 2 silver 1 IntAct: EBI-351193,EBI-3923949
BTK  » Tyrosine-protein kinase BTK silver 1 IntAct: EBI-351193,EBI-624835
CSNK2A1  » Casein kinase II subunit alpha silver 1 IntAct: EBI-347804,EBI-351193
DDX3X  » ATP-dependent RNA helicase DDX3X silver 3 IntAct: EBI-351193,EBI-353779
E2F3  » Transcription factor E2F3 silver 1 IntAct: EBI-351193,EBI-765551
EIF4A3  » Eukaryotic initiation factor 4A-III silver 1 IntAct: EBI-299104,EBI-351193
ESR1  » Estrogen receptor silver 1 IntAct: EBI-351193,EBI-78473
ESR2  » Estrogen receptor beta silver 2 IntAct: EBI-351193,EBI-78505
FOLH1  » Glutamate carboxypeptidase 2 silver 1 IntAct: EBI-1390372,EBI-351193
GABARAP  » Gamma-aminobutyric acid receptor-associated protein silver 1 IntAct: EBI-351193,EBI-712001
GABARAPL1  » Gamma-aminobutyric acid receptor-associated protein-like 1 silver 1 IntAct: EBI-351193,EBI-746969
GABARAPL2  » Gamma-aminobutyric acid receptor-associated protein-like 2 silver 1 IntAct: EBI-351193,EBI-720116
GNB2L1  » Guanine nucleotide-binding protein subunit beta-2-like 1 silver 1 IntAct: EBI-296739,EBI-351193
GRB2  » Growth factor receptor-bound protein 2 silver 1 IntAct: EBI-351193,EBI-401755
HTR7  » 5-hydroxytryptamine receptor 7 silver 1 IntAct: EBI-2625020,EBI-351193
IKBKB  » Inhibitor of nuclear factor kappa-B kinase subunit beta 4 IntAct: EBI-351193,EBI-81266
LRRK2  » Leucine-rich repeat serine/threonine-protein kinase 2 2 IntAct: EBI-351193,EBI-5323863
MAGOH  » Protein mago nashi homolog silver 1 IntAct: EBI-299134,EBI-351193
MAP1LC3A  » Microtubule-associated proteins 1A/1B light chain 3A silver 1 IntAct: EBI-351193,EBI-720768
MAP1LC3B  » Microtubule-associated proteins 1A/1B light chain 3B silver 1 IntAct: EBI-351193,EBI-373144
MAPK13  » Mitogen-activated protein kinase 13 silver 1 IntAct: EBI-2116951,EBI-351193
NDRG1  » Protein NDRG1 silver 1 IntAct: EBI-351193,EBI-716486
NEDD8  » NEDD8 2 IntAct: EBI-351193,EBI-716247
NFKB1  » Nuclear factor NF-kappa-B p105 subunit 2 IntAct: EBI-300010,EBI-351193
NFKBIA  » NF-kappa-B inhibitor alpha 6 IntAct: EBI-307386,EBI-351193
NS »  UniProtKB: O56264 Xeno silver 1 IntAct: EBI-351193,EBI-6150240
NS »  UniProtKB: P03496 Xeno silver 1 IntAct: EBI-2547442,EBI-351193
NS1 »  UniProtKB: D1LN35 Xeno silver 1 IntAct: EBI-351193,EBI-6152568
NS1 »  UniProtKB: Q9WPI5 Xeno silver 1 IntAct: EBI-351193,EBI-6149678
NXF1  » Nuclear RNA export factor 1 silver 1 IntAct: EBI-351193,EBI-398874
PPID  » Peptidyl-prolyl cis-trans isomerase D 4 IntAct: EBI-351193,EBI-716596
RELA  » Transcription factor p65 7 IntAct: EBI-351193,EBI-73886
RPL26  » 60S ribosomal protein L26 silver 1 IntAct: EBI-351193,EBI-352405
RPL9P9  » 60S ribosomal protein L9 silver 1 IntAct: EBI-351193,EBI-358122
SNW1  » SNW domain-containing protein 1 silver 1 IntAct: EBI-351193,EBI-632715
Smad6 »  UniProtKB: O35182 Xeno silver 1 IntAct: EBI-351193,EBI-4321242
UPF1  »  Regulator of nonsense transcripts 1 Isoform Iso 2 silver 1 IntAct: EBI-351193,EBI-373492
US11 »  UniProtKB: P04487 Xeno silver 1 IntAct: EBI-351193,EBI-6150681
US3 »  UniProtKB: P04413 Xeno silver 2 IntAct: EBI-351193,EBI-6148200
VCAM1  » Vascular cell adhesion protein 1 silver 3 IntAct: EBI-351193,EBI-6189824
YWHAZ  » 14-3-3 protein zeta/delta 2 IntAct: EBI-347088,EBI-351193
 Gold data
 Gold and silver data


DNA-binding  definition   [KW-0238]
RNA-binding  definition   [KW-0694]

Further external links

BioGrid: 112102 [ Interactions: 192 ]
IntAct: P23396 [ Interactions: 44 ]
MINT: MINT-4999144
STRING: 9606.ENSP00000278572