GLRA1 - Glycine receptor subunit alpha-1 - human protein (Function)
 
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GLRA1 »  Glycine receptor subunit alpha-1
 
Protein also known as:  Glycine receptor strychnine-binding subunit.
Gene name:  GLRA1
Entry whose protein(s) existence is based on evidence at protein level
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1 107 2
GENE REF ISO

Function

 show evidences
Overview 
The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing).  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the neurotransmitter receptor, cys loop, ligand-gated ion channel (lic) family  1.A.9.3.1  
GO molecular function 
Contributes to extracellular-glycine-gated chloride channel activitydefinition[GO:0016934]  
4
  • IGIMGI
  • IDAUniProtKB
Glycine bindingdefinition[GO:0016594]  
4
  • IDAUniProtKB
  • IDAMGI
Protein bindingdefinition[GO:0005515]  
1
  • IPIUniProtKB
Taurine bindingdefinition[GO:0030977]  
1
  • IDAUniProtKB
Transmitter-gated ion channel activitydefinition[GO:0022824] silver  
  • IEAInterPro 2 GO
GO biological process 
Acrosome reactiondefinition[GO:0007340] silver  
  • IEAOrtholog Compara
Action potentialdefinition[GO:0001508] silver  
  • IEAOrtholog Compara
Adult walking behaviordefinition[GO:0007628] silver  
  • IEAOrtholog Compara
Chloride transmembrane transportdefinition[GO:1902476]  
4
  • IGIGOC
Chloride transportdefinition[GO:0006821]  
1
  • IDAUniProtKB
Ion transportdefinition[GO:0006811]  
1
  • IDAUniProtKB
Muscle contractiondefinition[GO:0006936]  
1
  • IMPUniProtKB
Negative regulation of transmission of nerve impulsedefinition[GO:0051970]  
1
  • IMPUniProtKB
Neuromuscular process controlling posturedefinition[GO:0050884] silver  
  • IEAOrtholog Compara
Neuropeptide signaling pathwaydefinition[GO:0007218]  
1
  • IDAUniProtKB
Positive regulation of acrosome reactiondefinition[GO:2000344]  
1
  • IMPUniProtKB
Regulation of inhibitory postsynaptic membrane potentialdefinition[GO:0060080] silver  
  • IEAOrtholog Compara
Regulation of membrane potentialdefinition[GO:0042391]  
1
  • IMPMGI
Regulation of respiratory gaseous exchange by neurological system processdefinition[GO:0002087] silver  
  • IEAOrtholog Compara
Righting reflexdefinition[GO:0060013] silver  
  • IEAOrtholog Compara
Startle responsedefinition[GO:0001964]  
2
  • IMPUniProtKB
Synaptic transmission, glycinergicdefinition[GO:0060012] silver  
  • IEAOrtholog Compara
Visual perceptiondefinition[GO:0007601] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathway:
Neuroactive ligand-receptor interaction  hsa04080+2741  
According to Reactome, this protein belongs to the following pathway:
Transmembrane transport of small molecules  REACT_15518  
 

Keywords

Biological process 
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Chloride channel  definition   [KW-0869]
Ion channel  definition   [KW-0407]
Ligand-gated ion channel  definition   [KW-1071]
Receptor  definition   [KW-0675]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Glycine_receptor,_alpha_1
GenomeRNAi: 2741
PRO: PR:P23415
Chemistry
GuidetoPHARMACOLOGY: 423