JAK1 - Tyrosine-protein kinase JAK1 - human protein (Function)
 
Home Recent activites arrow-down favorite My favorites arrow-down favorite My labels arrow-down Downloads
Back to ...  
Publication View
Protein
Gene
References

 
JAK1 »  Tyrosine-protein kinase JAK1   [ EC 2.7.10.2 ]
 
Protein also known as:  Janus kinase 1 (JAK-1).
Gene name:  JAK1
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 140 1
GENE REF ISO

Function

 show evidences
Overview 
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.  
  • CuratedUniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
CCR5 chemokine receptor bindingdefinition[GO:0031730] silver  
  • IEAOrtholog Compara
Growth hormone receptor bindingdefinition[GO:0005131]  
1
  • ISSBHF-UCL
Non-membrane spanning protein tyrosine kinase activitydefinition[GO:0004715]  
  • IEAEC 2 GO
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
GO biological process 
Enzyme linked receptor protein signaling pathwaydefinition[GO:0007167] silver  
  • IEAOrtholog Compara
Intracellular signal transductiondefinition[GO:0035556]  
1
  • TASPINC
Protein autophosphorylationdefinition[GO:0046777] silver  
  • IEAOrtholog Compara
Protein phosphorylationdefinition[GO:0006468]  
1
  • TASPINC
Response to antibioticdefinition[GO:0046677]  
1
  • IDAMGI
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.2: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
  • CuratedUniProtKB
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Hepatitis C  hsa05160+3716  
Herpes simplex infection  hsa05168+3716  
HTLV-I infection  hsa05166+3716  
Influenza A  hsa05164+3716  
Jak-STAT signaling pathway  hsa04630+3716  
Leishmaniasis  hsa05140+3716  
Measles  hsa05162+3716  
Osteoclast differentiation  hsa04380+3716  
Pancreatic cancer  hsa05212+3716  
Pathways in cancer  hsa05200+3716  
Toxoplasmosis  hsa05145+3716  
Tuberculosis  hsa05152+3716  
According to Reactome, this protein belongs to the following pathway:
Immune System  REACT_6900  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Janus_kinase_1
GenomeRNAi: 3716
PRO: PR:P23458
Chemistry
GuidetoPHARMACOLOGY: 2047