JAK1 - Tyrosine-protein kinase JAK1 - human protein (Function)
 
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JAK1 »  Tyrosine-protein kinase JAK1   [ EC 2.7.10.2 ]
 
Protein also known as:  Janus kinase 1 (JAK-1).
Gene name:  JAK1
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.  
2
  • UniProtKB
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
CCR5 chemokine receptor bindingdefinition[GO:0031730] silver  
1
  • Ortholog Compara
Growth hormone receptor bindingdefinition[GO:0005131]  
2
  • BHF-UCL
  • RefGenome
Non-membrane spanning protein tyrosine kinase activitydefinition[GO:0004715]  
1
  • RefGenome
Protein bindingdefinition[GO:0005515]  
3
  • IntAct
  • UniProtKB
Protein phosphatase bindingdefinition[GO:0019903]  
1
  • UniProtKB
Ubiquitin protein ligase bindingdefinition[GO:0031625]  
1
  • UniProtKB
GO biological process 
Cell differentiationdefinition[GO:0030154]  
1
  • RefGenome
Cell migrationdefinition[GO:0016477]  
1
  • RefGenome
Innate immune responsedefinition[GO:0045087]  
1
  • RefGenome
Interleukin-2-mediated signaling pathwaydefinition[GO:0038110]  
1
  • UniProtKB
Intracellular signal transductiondefinition[GO:0035556]  
1
  • PINC
Peptidyl-tyrosine autophosphorylationdefinition[GO:0038083]  
1
  • RefGenome
Protein phosphorylationdefinition[GO:0006468]  
1
  • PINC
Regulation of cell proliferationdefinition[GO:0042127]  
1
  • RefGenome
Response to antibioticdefinition[GO:0046677]  
1
  • MGI
Transmembrane receptor protein tyrosine kinase signaling pathwaydefinition[GO:0007169]  
1
  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 2.7.10.2: ATP + a [protein]-L-tyrosine ADP + a [protein]-L-tyrosine phosphate.  
2
  • UniProtKB
  • PROSITE-ProRule
 
More information is available from:
Pathways 
According to KEGG, this protein belongs to the following pathways:
Hepatitis C  hsa05160+3716  
Herpes simplex infection  hsa05168+3716  
HTLV-I infection  hsa05166+3716  
Influenza A  hsa05164+3716  
Jak-STAT signaling pathway  hsa04630+3716  
Leishmaniasis  hsa05140+3716  
Measles  hsa05162+3716  
Osteoclast differentiation  hsa04380+3716  
Pancreatic cancer  hsa05212+3716  
Pathways in cancer  hsa05200+3716  
Toxoplasmosis  hsa05145+3716  
Tuberculosis  hsa05152+3716  
According to Reactome, this protein belongs to the following pathways:
G beta:gamma signalling through PI3Kgamma  R-HSA-392451  
GPVI-mediated activation cascade  R-HSA-114604  
Interferon alpha/beta signaling  R-HSA-909733  
Interferon gamma signaling  R-HSA-877300  
Interleukin receptor SHC signaling  R-HSA-912526  
Interleukin-2 signaling  R-HSA-451927  
Interleukin-6 signaling  R-HSA-1059683  
Interleukin-7 signaling  R-HSA-1266695  
ISG15 antiviral mechanism  R-HSA-1169408  
MAPK1 (ERK2) activation  R-HSA-112411  
MAPK3 (ERK1) activation  R-HSA-110056  
RAF/MAP kinase cascade  R-HSA-5673001  
Regulation of IFNA signaling  R-HSA-912694  
Regulation of IFNG signaling  R-HSA-877312  
 

Keywords

Molecular function 
Kinase  definition   [KW-0418]
Transferase  definition   [KW-0808]
Tyrosine-protein kinase  definition   [KW-0829]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Other
GeneWiki: Janus_kinase_1
GenomeRNAi: 3716
PRO: PR:P23458
Chemistry
GuidetoPHARMACOLOGY: 2047