AHCY - Adenosylhomocysteinase - human protein (Function)
 
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AHCY »  Adenosylhomocysteinase   [ EC 3.3.1.1 ]  (AdoHcyase)
 
Protein also known as:  S-adenosyl-L-homocysteine hydrolase.
Gene name:  AHCY
Family name: Adenosylhomocysteinase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
1 48 2
GENE REF ISO

Function

 show evidences
Overview 
Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.  
1
  • CuratedUniProtKB
GO molecular function 
Adenosylhomocysteinase activitydefinition[GO:0004013]  
1
  • TASUniProtKB
GO biological process 
One-carbon metabolic processdefinition[GO:0006730]  
  • IEAUniProtKB KW
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.3.1.1: S-adenosyl-L-homocysteine + H(2)O L-homocysteine + adenosine.  
  • CuratedUniProtKB
It requires the following cofactor
Binds 1 NAD per subunit.  
2
  • CuratedUniProtKB
Pathways 
This protein is involved in the following pathway
According to KEGG, this protein belongs to the following pathways:
Cysteine and methionine metabolism  hsa00270+191  
Metabolic pathways  hsa01100+191  
According to Reactome, this protein belongs to the following pathway:
Metabolism  REACT_111217  
 

Keywords

Biological process 
One-carbon metabolism  definition   [KW-0554]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P23526
Other
GenomeRNAi: 191
PRO: PR:P23526
Chemistry
GuidetoPHARMACOLOGY: 1233