AHCY - Adenosylhomocysteinase - human protein (Function)
 
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AHCY »  Adenosylhomocysteinase   [ EC 3.3.1.1 ]  (AdoHcyase)
 
Protein also known as:  S-adenosyl-L-homocysteine hydrolase.
Gene name:  AHCY
Family name: Adenosylhomocysteinase
Entry whose protein(s) existence is based on evidence at protein level
extend overview
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GENE REF ISO

Function

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Overview 
Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.  
2
  • UniProtKB
GO molecular function 
Adenosylhomocysteinase activitydefinition[GO:0004013]  
1
  • UniProtKB
Adenyl nucleotide bindingdefinition[GO:0030554] silver  
1
  • Ortholog Compara
Identical protein bindingdefinition[GO:0042802] silver  
1
  • Ortholog Compara
NAD bindingdefinition[GO:0051287] silver  
1
  • Ortholog Compara
Protein bindingdefinition[GO:0005515]  
1
  • IntAct
GO biological process 
Chronic inflammatory response to antigenic stimulusdefinition[GO:0002439] silver  
1
  • Ortholog Compara
Circadian sleep/wake cycledefinition[GO:0042745] silver  
1
  • Ortholog Compara
Homocysteine biosynthetic processdefinition[GO:0071268] silver  
1
  • Ortholog Compara
One-carbon metabolic processdefinition[GO:0006730]  
1
  • UniProtKB KW
Response to hypoxiadefinition[GO:0001666] silver  
1
  • Ortholog Compara
Response to nutrientdefinition[GO:0007584] silver  
1
  • Ortholog Compara
S-adenosylhomocysteine catabolic processdefinition[GO:0019510] silver  
1
  • Ortholog Compara
S-adenosylmethionine cycledefinition[GO:0033353]  
1
  • RefGenome
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.3.1.1: S-adenosyl-L-homocysteine + H(2)O L-homocysteine + adenosine.  
1
  • UniProtKB
It requires the following cofactor
 NAD(+) : Binds 1 NAD(+) per subunit.  
3
  • UniProtKB
 
More information is available from:
Pathways 
This protein is involved in the following pathway
Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1  
1
  • UniProtKB
According to KEGG, this protein belongs to the following pathways:
Cysteine and methionine metabolism  hsa00270+191  
Metabolic pathways  hsa01100+191  
According to Reactome, this protein belongs to the following pathways:
Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD)  R-HSA-5578997  
Methylation  R-HSA-156581  
Sulfur amino acid metabolism  R-HSA-1614635  
 

Keywords

Biological process 
One-carbon metabolism  definition   [KW-0554]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

Enzyme and pathway databases
SABIO-RK: P23526
Other
GenomeRNAi: 191
PRO: PR:P23526
Chemistry
GuidetoPHARMACOLOGY: 1233