CFL1 - Cofilin-1 - human protein (Function)
 
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Protein
Gene
References

 
CFL1 »  Cofilin-1
 
Protein also known as:  Cofilin, non-muscle isoform.
Gene name:  CFL1
Entry whose protein(s) existence is based on evidence at protein level
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1 297 1
GENE REF ISO

Function

 show evidences
Overview 
Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation.  
4
  • UniProtKB
GO molecular function 
Actin bindingdefinition[GO:0003779]  
1
  • UniProtKB KW
Protein bindingdefinition[GO:0005515]  
8
  • IntAct
  • AgBase
GO biological process 
Actin cytoskeleton organizationdefinition[GO:0030036]  
1
  • PINC
Actin filament depolymerizationdefinition[GO:0030042] silver  
1
  • InterPro 2 GO
Cytoskeleton organizationdefinition[GO:0007010]  
1
  • UniProtKB
Establishment of cell polaritydefinition[GO:0030010] silver  
1
  • Ortholog Compara
Mitotic cytokinesisdefinition[GO:0000281] silver  
1
  • Ortholog Compara
Negative regulation of apoptotic processdefinition[GO:0043066]  
1
  • UniProtKB
Negative regulation of cell sizedefinition[GO:0045792] silver  
1
  • Ortholog Compara
Neural crest cell migrationdefinition[GO:0001755] silver  
1
  • Ortholog Compara
Neural fold formationdefinition[GO:0001842] silver  
1
  • Ortholog Compara
Positive regulation of actin filament depolymerizationdefinition[GO:0030836] silver  
1
  • Ortholog Compara
Protein import into nucleusdefinition[GO:0006606] silver  
1
  • Ortholog Compara
Protein phosphorylationdefinition[GO:0006468] silver  
1
  • Ortholog Compara
Regulation of cell morphogenesisdefinition[GO:0022604]  
1
  • UniProtKB
Regulation of dendritic spine morphogenesisdefinition[GO:0061001]  
1
  • ParkinsonsUK-UCL
Response to amino aciddefinition[GO:0043200] silver  
1
  • Ortholog Compara
Response to virusdefinition[GO:0009615]  
1
  • UniProtKB
Rho protein signal transductiondefinition[GO:0007266]  
1
  • PINC
Pathways 
According to KEGG, this protein belongs to the following pathways:
Axon guidance  hsa04360+1072  
Fc gamma R-mediated phagocytosis  hsa04666+1072  
Pertussis  hsa05133+1072  
Regulation of actin cytoskeleton  hsa04810+1072  
According to Reactome, this protein belongs to the following pathways:
EPHB-mediated forward signaling  REACT_263952  
Platelet degranulation  REACT_318  
Regulation of actin dynamics for phagocytic cup formation  REACT_160086  
Sema3A PAK dependent Axon repulsion  REACT_19236  
 

Keywords

Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: Cofilin_1
GenomeRNAi: 1072
PRO: PR:P23528