BDNF - Brain-derived neurotrophic factor - human protein (Function)
 
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BDNF »  Brain-derived neurotrophic factor  (BDNF)
 
Protein also known as:  Abrineurin.
Gene name:  BDNF
Family name: NGF-beta
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

 show evidences
Overview 
During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.  
2
  • UniProtKB
GO molecular function 
Growth factor activitydefinition[GO:0008083]  
1
  • UniProtKB KW
Neurotrophin TRKB receptor bindingdefinition[GO:0005169]  
1
  • RefGenome
GO biological process 
Axon extensiondefinition[GO:0048675] silver  
1
  • Ortholog Compara
Axon guidancedefinition[GO:0007411] silver  
1
  • Ortholog Compara
Axon target recognitiondefinition[GO:0007412] silver  
1
  • Ortholog Compara
Behavioral fear responsedefinition[GO:0001662] silver  
1
  • Ortholog Compara
Cellular response to nerve growth factor stimulusdefinition[GO:1990090] silver  
1
  • Ortholog Compara
Cellular response to norepinephrine stimulusdefinition[GO:0071874] silver  
1
  • Ortholog Compara
Cellular response to tumor necrosis factordefinition[GO:0071356] silver  
1
  • Ortholog Compara
Chronic inflammatory responsedefinition[GO:0002544] silver  
1
  • Ortholog Compara
Circadian rhythmdefinition[GO:0007623] silver  
1
  • Ortholog Compara
Dendrite developmentdefinition[GO:0016358] silver  
1
  • Ortholog Compara
Dendrite extensiondefinition[GO:0097484] silver  
1
  • Ortholog Compara
Feeding behaviordefinition[GO:0007631] silver  
1
  • Ortholog Compara
Gamma-aminobutyric acid signaling pathwaydefinition[GO:0007214] silver  
1
  • Ortholog Compara
Glutamate secretiondefinition[GO:0014047] silver  
1
  • Ortholog Compara
Inner ear developmentdefinition[GO:0048839] silver  
1
  • Ortholog Compara
Learningdefinition[GO:0007612] silver  
1
  • Ortholog Compara
Mechanoreceptor differentiationdefinition[GO:0042490] silver  
1
  • Ortholog Compara
Mitochondrial electron transport, NADH to ubiquinonedefinition[GO:0006120] silver  
1
  • Ortholog Compara
Negative regulation of neuroblast proliferationdefinition[GO:0007406] silver  
1
  • Ortholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524]  
1
  • RefGenome
Negative regulation of striated muscle tissue developmentdefinition[GO:0045843] silver  
1
  • Ortholog Compara
Negative regulation of synaptic transmission, GABAergicdefinition[GO:0032229] silver  
1
  • Ortholog Compara
Nerve developmentdefinition[GO:0021675] silver  
1
  • Ortholog Compara
Nervous system developmentdefinition[GO:0007399]  
1
  • PINC
Neuron projection morphogenesisdefinition[GO:0048812]  
1
  • RefGenome
Neuron recognitiondefinition[GO:0008038] silver  
1
  • Ortholog Compara
Positive regulation of long-term neuronal synaptic plasticitydefinition[GO:0048170] silver  
1
  • Ortholog Compara
Positive regulation of neuron differentiationdefinition[GO:0045666] silver  
1
  • Ortholog Compara
Positive regulation of peptidyl-serine phosphorylationdefinition[GO:0033138] silver  
1
  • Ortholog Compara
Positive regulation of synapse assemblydefinition[GO:0051965]  
1
  • BHF-UCL
Regulation of axon extensiondefinition[GO:0030516] silver  
1
  • Ortholog Compara
Regulation of excitatory postsynaptic membrane potentialdefinition[GO:0060079] silver  
1
  • Ortholog Compara
Regulation of neuron differentiationdefinition[GO:0045664]  
1
  • RefGenome
Regulation of retinal cell programmed cell deathdefinition[GO:0046668] silver  
1
  • Ortholog Compara
Regulation of short-term neuronal synaptic plasticitydefinition[GO:0048172] silver  
1
  • Ortholog Compara
Response to activitydefinition[GO:0014823] silver  
1
  • Ortholog Compara
Response to anestheticdefinition[GO:0072347] silver  
1
  • Ortholog Compara
Response to auditory stimulusdefinition[GO:0010996] silver  
1
  • Ortholog Compara
Response to electrical stimulusdefinition[GO:0051602] silver  
1
  • Ortholog Compara
Response to fluoxetinedefinition[GO:0014076] silver  
1
  • Ortholog Compara
Response to fooddefinition[GO:0032094] silver  
1
  • Ortholog Compara
Response to hormonedefinition[GO:0009725] silver  
1
  • Ortholog Compara
Response to hyperoxiadefinition[GO:0055093] silver  
1
  • Ortholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
1
  • Ortholog Compara
Response to L-glutamatedefinition[GO:1902065] silver  
1
  • Ortholog Compara
Response to light intensitydefinition[GO:0009642] silver  
1
  • Ortholog Compara
Response to potassium iondefinition[GO:0035864] silver  
1
  • Ortholog Compara
Response to vitamin Adefinition[GO:0033189] silver  
1
  • Ortholog Compara
Taste bud developmentdefinition[GO:0061193] silver  
1
  • Ortholog Compara
Transmembrane receptor protein tyrosine kinase signaling pathwaydefinition[GO:0007169]  
1
  • RefGenome
Ureteric bud developmentdefinition[GO:0001657] silver  
1
  • Ortholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Huntington's disease  hsa05016+627  
MAPK signaling pathway  hsa04010+627  
Neurotrophin signaling pathway  hsa04722+627  
 

Keywords

Molecular function 
Growth factor  definition   [KW-0339]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links