BDNF - Brain-derived neurotrophic factor - human protein (Function)
 
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BDNF »  Brain-derived neurotrophic factor  (BDNF)
 
Protein also known as:  Abrineurin.
Gene name:  BDNF
Family name: NGF-beta
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.  
1
  • CuratedUniProtKB
GO molecular function 
Growth factor activitydefinition[GO:0008083]  
  • IEAUniProtKB KW
Neurotrophin TRKB receptor bindingdefinition[GO:0005169] silver  
  • IEAOrtholog Compara
GO biological process 
Axon guidancedefinition[GO:0007411] silver  
  • IEAOrtholog Compara
Axon target recognitiondefinition[GO:0007412] silver  
  • IEAOrtholog Compara
Behavioral fear responsedefinition[GO:0001662] silver  
  • IEAOrtholog Compara
Chronic inflammatory responsedefinition[GO:0002544] silver  
  • IEAOrtholog Compara
Dendrite developmentdefinition[GO:0016358] silver  
  • IEAOrtholog Compara
Feeding behaviordefinition[GO:0007631] silver  
  • IEAOrtholog Compara
Glutamate secretiondefinition[GO:0014047] silver  
  • IEAOrtholog Compara
Inner ear developmentdefinition[GO:0048839] silver  
  • IEAOrtholog Compara
Learning or memorydefinition[GO:0007611] silver  
  • IEAOrtholog Compara
Mechanoreceptor differentiationdefinition[GO:0042490] silver  
  • IEAOrtholog Compara
Mitochondrial electron transport, NADH to ubiquinonedefinition[GO:0006120] silver  
  • IEAOrtholog Compara
Negative regulation of neuroblast proliferationdefinition[GO:0007406] silver  
  • IEAOrtholog Compara
Negative regulation of neuron apoptotic processdefinition[GO:0043524] silver  
  • IEAOrtholog Compara
Negative regulation of striated muscle tissue developmentdefinition[GO:0045843] silver  
  • IEAOrtholog Compara
Nerve developmentdefinition[GO:0021675] silver  
  • IEAOrtholog Compara
Nervous system developmentdefinition[GO:0007399]  
1
  • TASPINC
Neuron recognitiondefinition[GO:0008038] silver  
  • IEAOrtholog Compara
Positive regulation of long-term neuronal synaptic plasticitydefinition[GO:0048170] silver  
  • IEAOrtholog Compara
Positive regulation of neuron differentiationdefinition[GO:0045666] silver  
  • IEAOrtholog Compara
Positive regulation of synapse assemblydefinition[GO:0051965]  
1
  • IDABHF-UCL
Regulation of excitatory postsynaptic membrane potentialdefinition[GO:0060079] silver  
  • IEAOrtholog Compara
Regulation of metabolic processdefinition[GO:0019222] silver  
  • IEAOrtholog Compara
Regulation of retinal cell programmed cell deathdefinition[GO:0046668] silver  
  • IEAOrtholog Compara
Regulation of short-term neuronal synaptic plasticitydefinition[GO:0048172] silver  
  • IEAOrtholog Compara
Response to anestheticdefinition[GO:0072347] silver  
  • IEAOrtholog Compara
Response to fluoxetinedefinition[GO:0014076] silver  
  • IEAOrtholog Compara
Response to hormonedefinition[GO:0009725] silver  
  • IEAOrtholog Compara
Response to hyperoxiadefinition[GO:0055093] silver  
  • IEAOrtholog Compara
Response to hypoxiadefinition[GO:0001666] silver  
  • IEAOrtholog Compara
Response to vitamin Adefinition[GO:0033189] silver  
  • IEAOrtholog Compara
Ureteric bud developmentdefinition[GO:0001657] silver  
  • IEAOrtholog Compara
Pathways 
According to KEGG, this protein belongs to the following pathways:
Huntington's disease  hsa05016+627  
MAPK signaling pathway  hsa04010+627  
Neurotrophin signaling pathway  hsa04722+627  
 

Keywords

Molecular function 
Growth factor  definition   [KW-0339]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links