BDNF - Brain-derived neurotrophic factor - human protein (Sequence)
 
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Protein
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BDNF »  Brain-derived neurotrophic factor  (BDNF)
 
Protein also known as:  Abrineurin.
Gene name:  BDNF
Family name: NGF-beta
Entry whose protein(s) existence is based on evidence at protein level
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1 94 5
GENE REF ISO

Displayed isoform: Iso 1     

 
 
Isoform Iso 1   247 aaMass: 27818 Da,  pI: 9.01
MTILFLTMVI SYFGCMKAAP MKEANIRGQG GLAYPGVRTH GTLESVNGPK AGSRGLTSLA DTFEHVIEEL LDEDQKVRPN EENNKDADLY TSRVMLSSQV PLEPPLLFLL EEYKNYLDAA NMSMRVRRHS DPARRGELSV CDSISEWVTA ADKKTAVDMS GGTVTVLEKV PVSKGQLKQY FYETKCNPMG YTKEGCRGID KRHWNSQCRT TQSYVRALTM DSKKRIGWRF IRIDTSCVCT LTIKRGR

Sequence

 show evidences
PTM 
The propeptide is N-glycosylated and glycosulfated.  
  • CuratedUniProtKB
Converted into mature BDNF by plasmin (PLG) (By similarity).  
  • CuratedUniProtKB
 

Keywords

Coding sequence diversity 
Alternative promoter usage  definition   [KW-0877]
Alternative splicing  definition   [KW-0025]
Polymorphism  definition   [KW-0621]
Domain 
Signal  definition   [KW-0732]
PTM 
Cleavage on pair of basic residues  definition   [KW-0165]
Disulfide bond  definition   [KW-1015]
Glycoprotein  definition   [KW-0325]
Technical term 
Direct protein sequencing  definition   [KW-0903]
Reference proteome  definition   [KW-1185]
 

Further external links

Family and domain databases
InterPro: IPR019846 [ Nerve growth factor CS ]
InterPro: IPR020408 [ Nerve growth factor-like ]
InterPro: IPR020430 [ Brain-der neurotrophic factor ]
InterPro: IPR002072 [ Nerve growth factor-rel ]
PANTHER: PTHR11589 [ PTHR11589 ]
Pfam: PF00243 [ NGF ]
PIRSF: PIRSF001789 [ NGF ]
PRINTS: PR00268 [ NGF ]
PRINTS: PR01912 [ BDNFACTOR ]
ProDom: PD002052 [ Nerve growth factor-rel ]
PROSITE: PS00248 [ NGF 1 ]
PROSITE: PS50270 [ NGF 2 ]
SMART: SM00140 [ NGF ]
Genome annotation databases
Ensembl: Transcript: ENST00000314915;  Protein: ENSP00000320002;  Gene: ENSG00000176697.
Ensembl: Transcript: ENST00000356660;  Protein: ENSP00000349084;  Gene: ENSG00000176697.
Ensembl: Transcript: ENST00000420794;  Protein: ENSP00000389564;  Gene: ENSG00000176697.
Ensembl: Transcript: ENST00000438929;  Protein: ENSP00000414303;  Gene: ENSG00000176697.
Ensembl: Transcript: ENST00000395980;  Protein: ENSP00000379304;  Gene: ENSG00000176697.
Ensembl: Transcript: ENST00000395986;  Protein: ENSP00000379309;  Gene: ENSG00000176697.
Ensembl: Transcript: ENST00000418212;  Protein: ENSP00000400502;  Gene: ENSG00000176697.
Ensembl: Transcript: ENST00000439476;  Protein: ENSP00000389345;  Gene: ENSG00000176697.
Ensembl: Transcript: ENST00000395983;  Protein: ENSP00000379307;  Gene: ENSG00000176697.
Ensembl: Transcript: ENST00000395981;  Protein: ENSP00000379305;  Gene: ENSG00000176697.
Ensembl: Transcript: ENST00000395978;  Protein: ENSP00000379302;  Gene: ENSG00000176697.
Ensembl: Transcript: ENST00000525528;  Protein: ENSP00000437138;  Gene: ENSG00000176697.
Ensembl: Transcript: ENST00000533131;  Protein: ENSP00000432727;  Gene: ENSG00000176697.
Ensembl: Transcript: ENST00000533246;  Protein: ENSP00000432376;  Gene: ENSG00000176697.
Ensembl: Transcript: ENST00000530861;  Protein: ENSP00000435564;  Gene: ENSG00000176697.
Ensembl: Transcript: ENST00000530786;  Protein: ENSP00000433003;  Gene: ENSG00000176697.
Ensembl: Transcript: ENST00000532997;  Protein: ENSP00000435805;  Gene: ENSG00000176697.
Ensembl: Transcript: ENST00000525950;  Protein: ENSP00000432035;  Gene: ENSG00000176697.
KEGG: hsa:627
UCSC: uc001mrt.3
UCSC: uc001msa.3
UCSC: uc009yje.3
UCSC: uc001mru.3
UCSC: uc009yjf.3
Organism-specific databases
MGI: MGI:88145 [ Bdnf ]
Other
EvolutionaryTrace: P23560
PMAP-CutDB: Q6YNR3
PTM databases
PhosphoSite: P23560
Phylogenomic databases
eggNOG: NOG45248
HOVERGEN: HBG006494
InParanoid: P23560
KO: K04355
OMA: RVGWRFI
OrthoDB: EOG7RBZ8Z
PhylomeDB: P23560
Sequence databases
CCDS: CCDS7866.1 [ P23560-1 ]
CCDS: CCDS44558.1 [ P23560-4 ]
CCDS: CCDS7865.1 [ P23560-2 ]
CCDS: CCDS41628.1 [ P23560-3 ]
EMBL: Genomic DNA:  CH471064 . Translation:  EAW68274.1 .
EMBL: mRNA:  EF689012 . Translation:  ABS32252.1 .
EMBL: mRNA:  AK289853 . Translation:  BAF82542.1 .
EMBL: mRNA:  EF689009 . Translation:  ABS32249.1 .
EMBL: mRNA:  AY054396 . Translation:  AAL23561.1 .
EMBL: mRNA:  EF689021 . Translation:  ABS32261.1 .
EMBL: mRNA:  M61176 . Translation:  AAA69805.2 .
EMBL: Genomic DNA:  CH471064 . Translation:  EAW68276.1 .
EMBL: mRNA:  EF689015 . Translation:  ABS32255.1 .
EMBL: mRNA:  EF674521 . Translation:  ABS29025.1 .
EMBL: mRNA:  EF689014 . Translation:  ABS32254.1 .
EMBL: mRNA:  AF400438 . Translation:  AAK92487.1 .
EMBL: Genomic DNA:  M61181 . Translation:  AAA96140.1 .
EMBL: Genomic DNA:  CH471064 . Translation:  EAW68278.1 .
EMBL: mRNA:  EF689010 . Translation:  ABS32250.1 .
EMBL: mRNA:  EF689016 . Translation:  ABS32256.1 .
EMBL: mRNA:  AY054392 . Translation:  AAL23557.2 .
EMBL: mRNA:  X60201 . Translation:  CAA42761.1 .
EMBL: mRNA:  EF689013 . Translation:  ABS32253.1 .
EMBL: mRNA:  EF674520 . Translation:  ABS29024.1 .
EMBL: mRNA:  EF689020 . Translation:  ABS32260.1 .
EMBL: mRNA:  BC029795 . Translation:  AAH29795.1 .
EMBL: Genomic DNA:  CH471064 . Translation:  EAW68277.1 .
EMBL: mRNA:  AY054395 . Translation:  AAL23560.1 .
EMBL: mRNA:  AY054394 . Translation:  AAL23559.1 .
EMBL: Genomic DNA:  M37762 . Translation:  AAA51820.1 .
EMBL: Genomic DNA:  CH471064 . Translation:  EAW68275.1 .
EMBL: Genomic DNA:  CH471064 . Translation:  EAW68279.1 .
EMBL: mRNA:  AY054397 . Translation:  AAL23562.1 .
EMBL: mRNA:  AY054399 . Translation:  AAL23564.1 .
EMBL: mRNA:  EF689017 . Translation:  ABS32257.1 .
EMBL: mRNA:  AY054400 . Translation:  AAL23565.2 .
EMBL: mRNA:  EF689011 . Translation:  ABS32251.1 .
EMBL: mRNA:  EF689019 . Translation:  ABS32259.1 .
EMBL: mRNA:  AY656701 . Translation:  AAT74399.1 .
EMBL: mRNA:  EF689018 . Translation:  ABS32258.1 .
EMBL: mRNA:  EF674518 . Translation:  ABS29022.1 .
EMBL: mRNA:  AY054393 . Translation:  AAL23558.1 .
EMBL: Genomic DNA:  AY011481 . Translation:  AAG47514.1 .
EMBL: Genomic DNA:  AC104563 . No translation available.
EMBL: mRNA:  AY054398 . Translation:  AAL23563.1 .
EMBL: mRNA:  AK289763 . Translation:  BAF82452.1 .
EMBL: Genomic DNA:  AF411339 . Translation:  AAO15434.1 .
EMBL: mRNA:  X91251 . Translation:  CAA62632.1 .
EMBL: mRNA:  EF674517 . Translation:  ABS29021.1 .
EMBL: mRNA:  EF674519 . Translation:  ABS29023.1 .
IPI: IPI00336003
IPI: IPI00855724
IPI: IPI00012058
IPI: IPI00917851
IPI: IPI00377232
PIR: B36208
RefSeq: Protein:  NP_733927.1. Nucleotide sequence:  NM_170731.4.
RefSeq: Protein:  NP_001700.2. Nucleotide sequence:  NM_001709.4.
RefSeq: Protein:  NP_001137284.1. Nucleotide sequence:  NM_001143812.1.
RefSeq: Protein:  NP_001137281.1. Nucleotide sequence:  NM_001143809.1.
RefSeq: Protein:  NP_001137282.1. Nucleotide sequence:  NM_001143810.1.
RefSeq: Protein:  NP_001137285.1. Nucleotide sequence:  NM_001143813.1.
RefSeq: Protein:  NP_733929.1. Nucleotide sequence:  NM_170733.3.
RefSeq: Protein:  NP_733931.1. Nucleotide sequence:  NM_170735.5.
RefSeq: Protein:  NP_001137278.1. Nucleotide sequence:  NM_001143806.1.
RefSeq: Protein:  NP_001137288.1. Nucleotide sequence:  NM_001143816.1.
RefSeq: Protein:  NP_733930.1. Nucleotide sequence:  NM_170734.3.
RefSeq: Protein:  NP_001137286.1. Nucleotide sequence:  NM_001143814.1.
RefSeq: Protein:  NP_001137279.1. Nucleotide sequence:  NM_001143807.1.
RefSeq: Protein:  NP_001137280.1. Nucleotide sequence:  NM_001143808.1.
RefSeq: Protein:  NP_001137277.1. Nucleotide sequence:  NM_001143805.1.
RefSeq: Protein:  NP_001137283.1. Nucleotide sequence:  NM_001143811.1.
RefSeq: Protein:  NP_733928.1. Nucleotide sequence:  NM_170732.4.
UniProtKB: P23560 [ BDNF ]
Protocols and materials databases
DNASU: 627