ATP2B4 - Plasma membrane calcium-transporting ATPase 4 - human protein (Function)
 
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ATP2B4 »  Plasma membrane calcium-transporting ATPase 4   [ EC 3.6.3.8 ]  (PMCA4)
 
Protein also known as:  Plasma membrane calcium ATPase isoform 4.
Gene name:  ATP2B4
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.  
1
  • UniProtKB
According to TCDB this is a transporter from family:
the p-type atpase (p-atpase) superfamily  3.A.3.2.1  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
1
  • UniProtKB KW
Calcium-transporting ATPase activitydefinition[GO:0005388]  
1
  • BHF-UCL
Calmodulin bindingdefinition[GO:0005516]  
1
  • BHF-UCL
Metal ion bindingdefinition[GO:0046872]  
1
  • UniProtKB KW
Nitric-oxide synthase bindingdefinition[GO:0050998]  
1
  • BHF-UCL
Contributes to nitric-oxide synthase inhibitor activitydefinition[GO:0036487]  
2
  • BHF-UCL
Protein bindingdefinition[GO:0005515]  
6
  • UniProtKB
  • IntAct
  • BHF-UCL
Protein phosphatase 2B bindingdefinition[GO:0030346]  
1
  • BHF-UCL
Scaffold protein bindingdefinition[GO:0097110]  
1
  • Ortholog Curator
Contributes to sodium channel regulator activitydefinition[GO:0017080]  
1
  • Ortholog Curator
GO biological process 
Calcium ion homeostasisdefinition[GO:0055074]  
1
  • BHF-UCL
Calcium ion import across plasma membranedefinition[GO:0098703]  
1
  • BHF-UCL
Calcium ion transmembrane transportdefinition[GO:0070588]  
1
  • BHF-UCL
Cellular calcium ion homeostasisdefinition[GO:0006874]  
1
  • BHF-UCL
Cellular response to epinephrine stimulusdefinition[GO:0071872]  
1
  • BHF-UCL
Metabolic processdefinition[GO:0008152]  
1
  • UniProtKB KW
Negative regulation of adrenergic receptor signaling pathway involved in heart processdefinition[GO:1901205]  
1
  • BHF-UCL
Negative regulation of arginine catabolic processdefinition[GO:1900082]  
1
  • BHF-UCL
Negative regulation of calcineurin-NFAT signaling cascadedefinition[GO:0070885]  
1
  • BHF-UCL
Negative regulation of cardiac muscle hypertrophy in response to stressdefinition[GO:1903243]  
1
  • BHF-UCL
Negative regulation of citrulline biosynthetic processdefinition[GO:1903249]  
1
  • BHF-UCL
Negative regulation of nitric oxide biosynthetic processdefinition[GO:0045019]  
2
  • BHF-UCL
Negative regulation of nitric oxide mediated signal transductiondefinition[GO:0010751]  
1
  • BHF-UCL
Negative regulation of nitric-oxide synthase activitydefinition[GO:0051001]  
4
  • BHF-UCL
Negative regulation of peptidyl-cysteine S-nitrosylationdefinition[GO:1902083]  
1
  • BHF-UCL
Negative regulation of the force of heart contractiondefinition[GO:0098736]  
1
  • BHF-UCL
Positive regulation of cAMP-dependent protein kinase activitydefinition[GO:2000481]  
1
  • BHF-UCL
Positive regulation of peptidyl-serine phosphorylationdefinition[GO:0033138]  
1
  • BHF-UCL
Regulation of sodium ion transmembrane transportdefinition[GO:1902305]  
1
  • BHF-UCL
Regulation of transcription from RNA polymerase II promoterdefinition[GO:0006357]  
1
  • BHF-UCL
Response to hydrostatic pressuredefinition[GO:0051599]  
1
  • BHF-UCL
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.3.8: ATP + H(2)O + Ca(2+)(Side 1) ADP + phosphate + Ca(2+)(Side 2).  
1
  • UniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+493  
Pancreatic secretion  hsa04972+493  
Salivary secretion  hsa04970+493  
According to Reactome, this protein belongs to the following pathways:
Ion transport by P-type ATPases  REACT_25149  
Reduction of cytosolic Ca++ levels  REACT_23765  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATP2B4
GenomeRNAi: 493
PRO: PR:P23634