ATP2B4 - Plasma membrane calcium-transporting ATPase 4 - human protein (Function)
 
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ATP2B4 »  Plasma membrane calcium-transporting ATPase 4
 
Gene name:  ATP2B4
Entry whose protein(s) existence is based on evidence at protein level
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GENE REF ISO

Function

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Overview 
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium out of the cell.  
  • CuratedUniProtKB
According to TCDB this is a transporter from family:
the p-type atpase (p-atpase) superfamily  3.A.3.2.1  
GO molecular function 
ATP bindingdefinition[GO:0005524]  
  • IEAUniProtKB KW
Calcium-transporting ATPase activitydefinition[GO:0005388]  
  • IEAEC 2 GO
Calmodulin bindingdefinition[GO:0005516]  
  • IEAUniProtKB KW
Metal ion bindingdefinition[GO:0046872]  
  • IEAUniProtKB KW
Protein bindingdefinition[GO:0005515]  
3
  • IPIIntAct
  • IPIUniProtKB
Scaffold protein bindingdefinition[GO:0097110]  
  • ISSOrtholog Curator
Contributes to sodium channel regulator activitydefinition[GO:0017080]  
  • ISSOrtholog Curator
GO biological process 
Calcium ion transmembrane transportdefinition[GO:0070588] silver  
  • IEAInterPro 2 GO
Metabolic processdefinition[GO:0008152]  
  • IEAUniProtKB KW
Negative regulation of peptidyl-cysteine S-nitrosylationdefinition[GO:1902083]  
1
  • NASBHF-UCL
Regulation of sodium ion transmembrane transportdefinition[GO:1902305]  
1
  • ICBHF-UCL
Transportdefinition[GO:0006810]  
1
  • TASPINC
Enzymatic activity 
This protein acts as an enzyme. It is known to catalyze the following reaction
EC 3.6.3.8: ATP + H(2)O + Ca(2+)(Side 1) ADP + phosphate + Ca(2+)(Side 2).  
  • CuratedUniProtKB
Pathways 
According to KEGG, this protein belongs to the following pathways:
Calcium signaling pathway  hsa04020+493  
Pancreatic secretion  hsa04972+493  
Salivary secretion  hsa04970+493  
According to Reactome, this protein belongs to the following pathways:
Ion transport by P-type ATPases  REACT_25149  
Reduction of cytosolic Ca++ levels  REACT_23765  
 

Keywords

Biological process 
Calcium transport  definition   [KW-0109]
Ion transport  definition   [KW-0406]
Transport  definition   [KW-0813]
Molecular function 
Hydrolase  definition   [KW-0378]
Technical term 
Reference proteome  definition   [KW-1185]
 

Further external links

GeneWiki: ATP2B4
GenomeRNAi: 493
PRO: PR:P23634